Could Psychedelics Be The Cure For Migraines
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Could Psilocybin or other Seratonergic 5-HT Agonists replace medications like Rizatriptan?
I used to have migraines that would not go away for a 5-7 days at a time, and would happen once every few months. I used to often get headaches that were not as painful as a migraine. In my particular case, the migraines I had were only ever in one side of my head, which the migraine would pick at random.
For those of you who are unaware of what a migraine maybe, or have heard the term but are unsure of its true nature, let’s take a peek into what a migraine is. Migraine Headache Symptoms, Relief, Auras, Types & Medications also details the nature of migraine headaches.
What Is A Migraine Headache?
A lot of people use the term migraine to mean any kind of severe headache. A migraine is a the result of specific neurological changes within the brain. These changes lead to the pain felt with migraine headaches.
Miraines are exacerbated by sound, light, sometimes smell. Nausea and vomiting are not uncommon. Sometimes migraines involve only one side of the head. Migraines can be described as throbbing and pounding headaches which are made worse by sensitivity to light and sound. What is Migraine? - Migraine Research Foundation has written a illuminating piece here.
In my personal experience, microdosing psychedelics of a particular kind keep migraines at bay, and like prescription medication, can even break the most painful migraines in a matter of hours. The cause of migrains is yet to be understood.
Microdosing Psychedelics (Psilocybin Mushrooms and LSD)
Microdosing is taking the world over by a storm. Sub-perceptual doses of psychedelics seem to keep migrains at bay.
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My father is a psychiatrist. Once when I had a migraine which lasted for a week. I asked my father for something which might help. He informed me of Rezatriptan. When I heard the name, something clicked in my mind. “Triptan?” Interesting. After taking the Rezatriptan, the migraine was gone in about an hour, never to return again, yet. This intrigued me so much so that I started to do a detailed analysis of the pharmacology of the drug and noticed something peculiar. The molecular structure of Rezatriptan is rather similar and almost identical to Serotonin, Psilocybin, Psilocin, DMT, LSD etc. (LSD contains the moiety of both Dopamine and Serotonin).
Migraine Medications Compared To Psychedelics
According to Wikipedia, Rizatriptan was sold as Maxalt, which is a 5-HT1 receptor agonist. Rizatriptan is an FDA-approved drug to treat migraines and cluster headaches.
Psilocybin which is dephosphorylated to psilocin is a partial agonist for many serotonergic receptors. Psilocin is known to bind to 5-HT1A, 5-HT1D, and 5-HT2C. Microdosing Psychedelic Mushrooms and Migraines.
“Rizatriptan and Psilocin both agonize 5-HT1D at blood vessels and nerve endings in the brain.”
The molecular structure of Rizatriptan, Triptans (family), and Psychedelic tryptamines is very similar:
Serotonin is a monoamine neurotransmitter which regulates many primary functions in the brain and gastric system. Serotonin is associated with mood regulation, sleeping, and digestive health. Serotonin is closely related to adequate functioning of the mind and body.
Psilocin or 4-Hydroxy-N,N-dimethyltryptamine is the metabolite of Psilocybin (the active chemical in magic mushrooms). Psilocin is a seratonergic agonist and binds to 5HT receptors. Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches further goes into psychdelic treatment.
Rizatriptan is said to “work by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.”
Here is a study published by the American Academy of Neurology about a Response of cluster headache to psilocybin and LSD.
The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted.
I have used psychedelics for treating my migraines and I’ve found success Please comment on the article below and let us know how you treat your migraines.
- Migraine Headache Symptoms, Relief, Auras, Types & Medications
- What is Migraine? - Migraine Research Foundation
- Microdosing Psychedelic Mushrooms Migraine
- Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches