Could Psychedelics Be The Cure For Migraines

Could Psilocybin or other Seratonergic 5-HT Agonists replace medications like Rizatriptan?

Could Psychedelics Be The Cure For Migraines

Table Of Contents

psychedelic migraine treatment

Could Psilocybin or other Seratonergic 5-HT Agonists replace medications like Rizatriptan?

Short answer, for many people, yes!

I used to have migraines that would not go away for a 5-7 days at a time, and would happen once every few months. Just imagine living through a week long migraine.

In my particular case, the migraines I had were only ever in one side of my head, which the migraine would pick at random.

I used to be in severe pain, and as I began microdosing LSD and Psilocybin (among other 4 substituted tryptamines), I have not had any. It’s been 6 years since I have had any migraines or severe headaches. I also used to often get headaches that were not as painful as a migraine.

How do you go to work with a migraine? How do you even tell your boss that you have a migraine and is impeding your work? Most people dont’ really understand the debilitation nature of migraines.

What Is A Migraine Headache?

For those of you who are unaware of what a migraine maybe, or have heard the term but are unsure of its true nature, let’s take a peek into what a migraine is.

Migraines are experienced as excrutiating pain in the head. Some describe it as an icepick being slowly pushed into the brain. Almost everyone has headaches, even very painful ones, every now and then.1

Psychedelics Cure Migraines

Psychedelics Cure Migraines

Migraine is not simply a bad headache, contrary to popular thinking. Migraines are an extremely painful and incapacitating bundle of neural symptoms that induce a severe throbbing and recurring pain, usually only on one side of the head, which the migraine picks at random.

In about 33% of the migraines, both sides of the head are affected. The pain is severe, reported as being 9-10 on the pain scale.

There are different types of migraines. The migraine itself remains an elusive condition, as it is a moving target of research. The type of migraine is differenciated by its symptoms. There are migraines, cluster headaches, aura headaches and many more.

According to The Migraine Research Foundation:

Migraine is an extraordinarily prevalent neurological disease, affecting 39 million men, women and children in the U.S. and 1 billion worldwide.

A lot of people use the term migraine to mean any kind of severe headache. A migraine is a the result of specific neurological changes within the brain. These changes lead to the pain felt with migraine headaches.

Could Psychedelics Be The Cure For Migraines

Could Psychedelics Be The Cure For Migraines

Miraines are exacerbated (made worse) by sound, light, sometimes smell. Nausea and vomiting are not uncommon. A spinning head feeling is also commonly present. Extreme pressure around the sinus are is also reported, as well as throbbing temples.

Sometimes migraines involve only one side of the head. Migraines can be described as throbbing and pounding headaches which are made worse by sensitivity to light and sound.2

Migraines are an Extremely Common Neurological Disease

  • The 3rd most prevalent illness in the world are migraines (and cluster headaches).

  • 25% of the households in the United States have at least one victim of migraines.

  • 12% of the child population also suffers from migraines.

  • The most common ages of migraine sufferes is between 25 and 55.

  • 90% of the sufferers of migraines have a family history of migraines.

Many people don’t know how serious and incapacitating migraine are.

  • While most sufferers experience attacks once or twice a month, more than 4 million people have chronic daily migraine, with at least 15 migraine days per month.

  • More than 90% of the victims of migraines cannot perform work duties or have normal daily functionality during their migraines.

Migraines are extremely painful headaches that can stop a person from being functioning and living a normal life. They can render a person to the bed, writhing in pain, unable to do the most basic of tasks. Appetite becomes naturally suppressed, and as a result, the healthy of a person swiftly dwindles.

Microdosing Psychedelics Treat Migraines

In my personal experience, microdosing psychedelics of a particular kind keep migraines at bay, and like prescription medication, can even break the most painful migraines in a matter of hours. The cause of migrains is yet to be understood.

Give me the latest Microdosing Guides and Resources!

* indicates required

Many people are now pursuing self-treatment through psychedelic microdosing, instead of depending on Big Pharma. There was a study conducted which sheds more light on this: Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches

The study concluded that the patients are desperate for relief, and are even turning to illicit substances such as the classic psychedelics, LSD and magic mushrooms as a last resort, as they have no hope left from Big Pharma.

These people in such tremendous pain, that they are not interested in the psychoactive effects of these substances, but if they occur, they will tolerate them in order to find relief from the suffering and pain.

Most of the time, the psychoactive effects are mitigated by only taking a microdose, which is 1/10th of the effective dose.

Most notably psilocybin, lysergic acid diethylamide, and related psychedelic tryptamines were reportedly effective for both prophylactic and acute treatment of cluster headache and migraines.

Microdosing is taking the world over by a storm. Sub-perceptual doses of psychedelics seem to keep migrains at bay.3

Migraine Medications Compared To Psychedelics

My father is a psychiatrist. Once when I had a migraine which lasted for a week. I asked my father for something which might help. He informed me of Rezatriptan. When I heard the name, something clicked in my mind. “Triptan?” Interesting. After taking the Rezatriptan, the migraine was gone in about an hour, never to return again, yet.

This intrigued me so much so that I started to do a detailed analysis of the pharmacology of the drug and noticed something peculiar. The molecular structure of Rezatriptan is rather similar and almost identical to Serotonin, Psilocybin, Psilocin, DMT, LSD etc. (LSD contains the moiety of both Dopamine and Serotonin).

Psilocybin which is dephosphorylated to psilocin is a partial agonist for many serotonergic receptors. Psilocin is known to bind to 5-HT1A, 5-HT1D, and 5-HT2C.4

According to Wikipedia5, Rizatriptan was sold as Maxalt, which is a 5-HT1 receptor agonist. Rizatriptan is an FDA-approved drug to treat migraines and cluster headaches.

“Rizatriptan and Psilocin both agonize 5-HT1D at blood vessels and nerve endings in the brain.”



Serotonin6 is a monoamine neurotransmitter which regulates many primary functions in the brain and gastric system. Serotonin is associated with mood regulation, sleeping, and digestive health. Serotonin is closely related to adequate functioning of the mind and body.



Psilocin7 or 4-Hydroxy-N,N-dimethyltryptamine is the metabolite of Psilocybin (the active chemical in magic mushrooms)8. Psilocin is a seratonergic agonist and binds to 5HT receptors.



What I noticed was that the molecular structure of Rizatriptan, Triptans (family), and Psychedelic tryptamines is very similar:5678. They both look like the serotonin molecule and are serotonin receptor agonists.

Rizatriptan is said to:

“work by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.”

Psychedelic tryptamines such as Psilocybin and Psilocin also target the same 5HT1D receptor as Rizatraptan, which works to reduce bloodflow to the blood brain vessles. The 5HT1D receptor is they key receptor in inducing vasocontriction.

This has also been shown by functional neuro-imaging, that due to this vasocontricting effect of tryptamines, less oxygen flows to the brain during psychedelic treatment or a trip.

Here is a study published by the American Academy of Neurology about a Response of cluster headache to psilocybin and LSD.

The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted.


It seems that the molecular structure of migraine medicines is nearly identical to that of serotonin receptor agonists such as the psychedelics LSD and magic mushrooms.

Targeting the same receptors that medications do, psychedelic microdosing, with great benefits, can also eliminate migraines altogether.

I have used psychedelics for treating my migraines and I’ve found success. I have not had migraines in over 6 years becuase of psychedelic microdosing.

Please comment on the article below and let us know how you treat your migraines.