Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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Description

LSZ Also known as:

  • [(2S,4S)-2,4-Dimethyl-1-azetidinyl][(8β)-6-methyl-9,10-didehydroergolin-8-yl]methanon[German][ACD/IUPAC Name]
  • [(2S,4S)-2,4-Dimethyl-1-azetidinyl][(8β)-6-methyl-9,10-didehydroergolin-8-yl]methanone[ACD/IUPAC Name]
  • [(2S,4S)-2,4-Diméthyl-1-azétidinyl][(8β)-6-méthyl-9,10-didéhydroergolin-8-yl]méthanone[French][ACD/IUPAC Name]
  • LA-SS-Az
  • LSZ
  • Lysergic acid 2,4-dimethylazetidide[Wiki]
  • Methanone, [(8β)-9,10-didehydro-6-methylergolin-8-yl][(2S,4S)-2,4-dimethyl-1-azetidinyl]-[ACD/Index Name]
  • [(2S, 4S)-2,4-dimethylacetidin-1-yl][(8b)-6-methyl-9,10-didehydroergol-8-yl]methanone[ACD/IUPAC Name]

A lysergamide very similar to LSD usually distinguishable only by its shorter duration, though some subjective reports have noted it may be slightly more introspective and slightly less confusing.

Summary

In the 2000s, a team led by David E. Nichols at Purdue University set to develop a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. LSZ has little to no history of human usage prior to 2012 when it appeared on some research chemical markets in the UK.

LSZ later gained international popularity through a small cluster of mail-order novel psychedelic shops that appeared in 2012. There have also been several unconfirmed reports of LSZ being synthesized in illicit laboratories and distributed on blotter paper or in liquid solution under names such as “Diazedine” and “λ” (or “Lambda”). LSZ is not considered to be addictive or physiologically toxic.

Nevertheless, adverse psychological reactions such as severe anxiety, paranoia and psychosis are always possible, particularly among those predisposed to mental illness. It is highly advised to use harm reduction practices if using this substance.

Chemistry

It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure.

This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it. The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid).

At carbon 8 of the quinoline, an amide group is bound.

Additionally, the substitutions of the terminal nitrogen atom of the amide group form a 2,4-dimethylazetidide group.

LSZ is additionally substituted at carbon 6 with a methyl group. There are three possible stereoisomers around the azetidine ring with the (S,S)-(+) isomer being the most active.

It is slightly more potent than LSD itself in drug discrimination tests using trained rats.

Common NameLysergic acid 2,4-dimethylazetidide
Systematic nameLysergic acid 2,4-dimethylazetidide
FormulaC_{21}H_{25}N_{3}O
SMILESC[C@H]1C[C@@H](N1C(=O)[C@H]2CN([C@@H]3Cc4c[nH]c5c4c(ccc5)C3=C2)C)C
Std. InChiInChI=1S/C21H25N3O/c1-12-7-13(2)24(12)21(25)15-8-17-16-5-4-6-18-20(16)14(10-22-18)9-19(17)23(3)11-15/h4-6,8,10,12-13,15,19,22H,7,9,11H2,1-3H3/t12-,13-,15+,19+/m0/s1
Std. InChiKeyDUKNIHFTDAXJON-CTQRGLTFSA-N
Avg. Mass335.4427 Da
Molecular Weight335.4427
Monoisotopic Mass335.199768 Da
Nominal Mass335
ChemSpider ID30773535

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Dose Chart

Oral
Threshold80ug
Light100-150ug
Common150-300ug
Heavy300ug+

Duration Chart

LSZ Duration Data
Onset90-120 minutes
Duration7-10 hours
After-effects1-24 hours

Legal Status

  • Denmark: As of August 25, 2015, LSZ is specifically named on the list of illegal substances in Denmark.
  • Germany: LSZ is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Latvia: LSZ is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
  • Sweden: Following its sale as a designer drug, LSZ was made illegal in Sweden on January 26, 2016.
  • Switzerland: LSZ was added to the list of controlled substances on the December 1, 2015.
  • United Kingdom: As of January 7, 2015, LSZ is specifically named in the U.K. Misuse of Drugs Act as a Class A drug.

    • Sources

    References

    1. Nichols, D. E.; Frescas, S.; Marona-Lewicka, D.; Kurrasch-Orbaugh, D. M. (2002). "Lysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N,N-Diethyllysergamide (LSD)". Journal of Medicinal Chemistry. 45 (19): 4344–4349. :10.1021/jm020153s.  1520-4804.  0022-2623. OCLC 39480771. PMID 12213075.
    2. Advisory Council on the Misuse of Drugs (ACMD) (June 10, 2014). "Update of the generic definition for tryptamines" (PDF). Government Digital Service. p. 12. Retrieved January 1, 2020.
    3. Mike Power (January 29, 2014). "The Drug Revolution That No One Can Stop". Matter. Medium. Retrieved January 7, 2020.
    4. Cole, Krystle (2005). Lysergic. Indianapolis: Dog Ear Publishing.  1-59858-007-8.
    5. Hamilton Morris (May 1, 2011). "Life Is a Cosmic Giggle on the Breath of the Universe". VICE. Retrieved January 7, 2020.
    6. Lüscher, Christian; Ungless, Mark A. (2006). "The Mechanistic Classification of Addictive Drugs". PLOS Medicine. 3 (11). :10.1371/journal.pmed.0030437.  1549-1676.  1549-1277. PMID 17105338.
    7. Nichols, David E. (2016). Barker, Eric L., ed. "Psychedelics". Pharmacological Reviews. 68 (2): 264–355. :10.1124/pr.115.011478.  1521-0081.  0031-6997.
    8. Strassmann, Rick (1984). "Adverse reactions to psychedelic drugs. A review of the literature". Journal of Nervous and Mental Disease. 172 (10): 577–595. :10.1097/00005053-198410000-00001.  0022-3018. OCLC 1754691. PMID 6384428.
    9. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    10. "Bekendtgørelse om euforiserende stoffer - ni nye stoffer tilføjet" (in Danish). Danish Medicines Ageny. August 31, 2015. Retrieved January 1, 2020.
    11. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
    12. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. Retrieved January 1, 2020.
    13. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
    14. "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" (in Latvian). VSIA Latvijas Vēstnesis. November 10, 2005. Retrieved January 1, 2020.
    15. "31 nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten [Public Health Agency of Sweden]. January 26, 2016. Retrieved January 1, 2020.
    16. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel,psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien: Änderung vom 2. November 2015" (PDF) (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020.

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.