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ALD-52 Also known as:
iethyl-6-methyl-9,1[German][ACD/IUPAC Name] 0-didehydroergolin- 8-carboxamid
iethyl-6-methyl-9,1[ACD/IUPAC Name] 0-didehydroergoline -8-carboxamide
iéthyl-6-méthyl-9,1[French][ACD/IUPAC Name] 0-didéhydroergoline -8-carboxamide
- 1-ACETYLLYSERGIC AC
ide, 1-acetyl-9,10- didehydro-N,N-dieth yl-6-methyl-, (8β)-
ide, 1-acetyl-9,10-[ACD/Index Name] didehydro-N,N-dieth yl-6-methyl-, (8β)-
mide, 1-acetyl-9,10 -didehydro-N,N-diet hyl-6-methyl-
- (+)-Lysergic acid a
-azabicyclo[3.2.1]o ctan-3-yl] 2-(4-met hoxyphenyl)acetate
- 4-25-00-00972 (Beil
stein Handbook Refe[Beilstein] rence)
- D-1-Acetyl lysergic
ide, 1-acetyl-9,10- didehydro-N,N-dieth yl-6-methyl-, (8-β)-
- Lysergamide, 1-acet
yl-N,N-diethyl- (6C I,7CI)
ALD-52, or N-acetyl-LSD is a less common chemical analogue of LSD, first synthesised by Albert Hoffman. It was famously implicated in the ‘Orange Sunshine’ trial. A psychedelic lysergamide, this compound exhibits similar properties to LSD, and is thought to be a pro-drug for LSD.
It is structurally related to psychedelic lysergamides like LSD and 1P-LSD and is reported to produce largely indistinguishable effects. ALD-52 was originally discovered by in his study of LSD analogs, but it did not enter mainstream awareness until the 1960s Western youth counterculture. ALD-52 gained public notoriety when it was supposedly distributed as LSD in the 1960s under the now-famous name "Orange Sunshine.
" This was later disproven (see section below). Alexander Shulgin touches briefly on the subject of ALD-52 in the commentary section of LSD-25 in the book TiHKAL (“Tryptamines I have Known and Loved”). His writings are based on second-hand accounts which state that doses in the 50-175 µg range result in various effects that are not particularly distinct from LSD.
His reports indicate that it produces less visual distortion than with LSD as well as less anxiety and tenseness, while also being somewhat less potent than LSD. Another report found the two substances to be indistinguishable. As with LSD itself, ALD-52 does not meet the criteria to be considered addictive or toxic by the scientific community.
Nevertheless, unpredictable adverse reactions such as anxiety, paranoia, delusions and psychosis are always possible, particularly among those who are predisposed to psychiatric disorders. While these negative reactions or “bad trips” can often be attributed to factors like user inexperience or improper preparation of set and setting, they are known to happen spontaneously among even highly experienced users as well. It is highly advised to approach this very potent, long-lasting hallucinogenic substance with the proper amount of preparation, and harm reduction practices if using it.
In 1968 and 1969, a famous batch of LSD known as "Orange Sunshine" was synthesized by Nick Sands and Tim Scully and made widely available in California. This "Orange Sunshine" was long held by the hippie generation to be ALD-52 until 2005, when it was revealed by Nick Sands that "Orange Sunshine" was just a particularly well made batch of LSD dosed at 300 micrograms per unit. This was confirmed by Tim Scully in a 2017 Reddit AMA, where Scully explained that the claim that "Orange Sunshine" was technically not LSD arose from an "ill-advised desperate defense strategy that failed miserably" during his trial for LSD manufacture.
ALD-52 is a substituted derivative of lysergic acid.
ALD-52’s structure contains four rings, a bicyclic hexahydroindole fused to a bicyclic quinoline group.
This core structure of ALD-52 is an ergoline derivative, and has tryptamine and phenethylamine structures embedded within it.
ALD-52 contains a N,N-diethylcarboxamide functional group bound to R8 of the chemical structure.
It is additionally substituted at carbon 6 with a methyl group. ALD-52 is homologous to 1P-LSD, which contains a propionyl group bound to CH3CO- instead of the acetyl group bound to the same location.
It is unknown how these differences account for differences in the two compound’s activity.
|Common Name||1-ACETYLLYSERGIC ACID DIETHYLAMIDE|
|Systematic name||1-ACETYLLYSERGIC ACID DIETHYLA|
|SMILES||CCN(CC)C(=O)[[email protected]]1CN([[email protected]@H]2Cc3cn(c4c3c(ccc4)C2=C1)C(=O)C)C|
|Avg. Mass||365.4687 Da|
|Monoisotopic Mass||365.210327 Da|
|ALD-52 Duration Data|
The cognitive effects of ALD-52 can be broken down into several components which progressively intensify proportional to dosage. In comparison to other psychedelics such as psilocybin, LSA and ayahuasca, ALD-52 is significantly more stimulating and fast-paced in terms of the specific style of thought streams produced and contains a large number of potential effects that is attributed to its binding activity at a wide range of monoamine receptors other than serotonin, specifically dopamine and norepinephrine. The most prominent of these cognitive effects generally include:
- Analysis enhancement - This effect is consistent in its manifestation and introspection dominant.
- Anxiety & Paranoia - These effects are reported to be not as common at low to moderate doses and is less likely to occur when the basic rules of set and setting are taken into account. It should be noted that this inconsistently induced effect is seemingly more likely to manifest when used with cannabis. ALD-52 is often reported as producing less anxiety, particularly during the come up phase, relative to LSD.
- Conceptual thinking
- Creativity enhancement
- Cognitive euphoria - This component is, generally speaking less consistent and pronounced than it is with substances like psilocybin and MDMA. The mental euphoria experienced on LSD is usually simply due to an enhancement of the user’s current psychological and emotional state coupled with its more regularly occurring effect, physical euphoria.
- Déjà vu
- Ego replacement
- Emotion enhancement
- Focus enhancement - This effect is experienced exclusively on low or threshold dosages and feels less forced than it does with stimulants.
- Immersion enhancement
- Increased libido
- Increased music appreciation
- Memory suppression
- Multiple thought streams
- Novelty enhancement
- Personal bias suppression
- Personal meaning enhancement
- Personality regression
- Simultaneous emotions
- Suggestibility enhancement
- Thought acceleration
- Thought disorganization
- Thought loops
- Time distortion
ALD-52 likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from ALD-52’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. ALD-52, alongside with 1P-LSD, is believed to act as a prodrug to LSD, though it is unclear as to whether it is capable of exerting its own effects.
- Stimulation - In terms of its effects on the physical energy levels of the user, ALD-52 produces stimulating effects similar to LSD. This is in distinction to other, more commonly used psychedelics such as psilocybin which are more consistent in producing sedation and relaxedness.
- Spontaneous physical sensations - The "body high" of ALD-52 can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of ALD-52, this sensation often approaches its highest level and can become so overwhelming that people may find themselves writhing on the floor in pleasure.
- Tactile enhancement - Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most ALD-52 trips. If level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once is consistently present.
- Changes in felt bodily form - This effect is often accompanied by a sense of warmth or unity and usually occurs during and up to the peak of the experience or directly afterwards. Users can feel as if they are physically part of or conjoined with other objects. This is usually reported as feeling comfortable in its sensations and even peaceful.
- Perception of bodily lightness
- Nausea - Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly soon after the user has vomited or gradually fades by itself as the peak sets in.
- Stamina enhancement - This is generally mild in comparison to the stamina enhancement produced by traditional stimulants.
- Bodily control enhancement
- Appetite suppression
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Difficulty urinating
- Excessive yawning - This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
- Pupil dilation
- Increased salivation
- Seizure - Although no cases of ALD-52 induced seizures have been documented, it is likely to have a similar seizure risk as LSD. LSD is believed to lower the seizure threshold, although seizures are very rarely reported and believed to only be a risk to those who are predisposed to them, particularly in combination with physically taxing conditions such as dehydration, undernourishment, overheating, or general fatigue.
- Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
Anecdotal reports from many users suggest that the effects of ALD-52 are virtually identical to LSD. In comparison to other psychedelics such as psilocin, LSA and ayahuasca, ALD-52 is significantly more stimulating and fast-paced regarding the specific style of its physical and cognitive effects, as is the case with other lysergamides.
- Colour enhancement - In comparison to other psychedelics, this effect is often reported to be brighter but not as varied in its character.
- Pattern recognition enhancement
- Visual acuity enhancement
- Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed and cartoon-like in its appearance. The distortions are slow and smooth in motion and fleeting in appearance.
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
The visual geometry encountered on ALD-52 can be described as more similar in appearance to that of 2C-B or 2C-I than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, non-immersive in-depth and consistent in intensity.
ALD-52 is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics, specifically tryptamines like DMT or psilocybin mushrooms. These effects include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - Although ALD-52 is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, these effects are incredibly rare and inconsistent in comparison. While traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, ALD-52 will for most simply go straight into Level 8A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, LSD is simply not as deep of an experience as certain other psychedelics. On the rare occasion that they are induced, however, they can be comprehensively described in terms of their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability and geometry-based in appearance.
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
ALD-52 is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analog laws and with the intent to sell or consume.
- Shulgin, Alexander; Shulgin, Ann (1997). "#26. LSD-25". TiHKAL: The Continuation. United States: Transform Press. 0-9630096-9-9. OCLC 38503252.
- Lüscher, Christian; Ungless, Mark A. (2006). "The Mechanistic Classification of Addictive Drugs". PLOS Medicine. 3 (11). :10.1371/journal.pmed.0030437. 1549-1277. PMID 17105338.
- Nichols, David E. (2016). Barker, Eric L., ed. "Psychedelics". Pharmacological Reviews. 68 (2): 264–355. :10.1124/pr.115.011478. 0031-6997.
- Strassmann, Rick (1984). "Adverse reactions to psychedelic drugs. A review of the literature". Journal of Nervous and Mental Disease. 172 (10): 577–595. :10.1097/00005053-198410000-00001. 0022-3018. OCLC 1754691. PMID 6384428.
- "Earth"; "Jon Hanna"; "Spoon" (March 14, 2016). "Ask Erowid : ID 3189 : Was Orange Sunshine actually ALD-52?". Erowid. Retrieved January 1, 2020.
- Armstrong, B. D.; Paik, E.; Chhith, S.; Lelievre, V.; Waschek, J. A.; Howard, S. G. (2004). "Potentiation of (DL)‐3,4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939". Neuroscience Research Communications. 35 (2): 83–95. :10.1002/nrc.20023. 1520-6769.
- Gudelsky, Gary A.; Yamamoto, Bryan; Nash, J. Frank (1994). "Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists". European Journal of Pharmacology. 264 (3): 325–330. :10.1016/0014-2999(94)90669-6. 0014-2999.
- Capela, J. P.; Fernandes, E.; Remião, F.; Bastos, M. L.; Meisel, A.; Carvalho, F. (2007). "Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons". Neurotoxicology. 28 (4): 868–875. :10.1016/j.neuro.2007.04.005. 0161-813X. PMID 17572501.
- Passie, T.; Halpern, J. H.; Stichtenoth, D. O.; Emrich, H. M.; Hintzen, A. "The Pharmacology of Lysergic Acid Diethylamide: A Review" (PDF). CNS Neuroscience & Therapeutics. 14: 295–314. :10.1111/j.1755-5949.2008.00059.x. 1755-5930. Archived from the original (PDF) on May 1, 2013. Retrieved January 1, 2020.
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- "Samlet liste over euforiserende stoffer opført på bilag 1 til bekendtgørelsen om euforiserende stoffer nr. 557 af 31. maj 2011 og stoffer reguleret herefter via ændringsbekendtgørelser" (in Danish). Lægemiddelstyrelsen [Danish Medicines Agency]. June 13, 2018. Retrieved January 1, 2020.
- "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
- "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF). Bundesgesetzblatt Jahrgang 2019 Teil I Nr. 27 (in German). Bundesanzeiger Verlag. July 17, 2019. pp. 1083–1094. Retrieved January 1, 2020.
- "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz [Federal Ministry of Justice and Consumer Protection]. Retrieved December 10, 2019.
- "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" (in Latvian). VSIA Latvijas Vēstnesis. November 10, 2005. Retrieved January 1, 2020.
- "Rozporządzenie Ministra zdrowia z dnia 21 sierpnia 2019 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych" (PDF) (in Polish).
- Advisory Council on the Misuse of Drugs (June 10, 2014). "Update of the generic definition for tryptamines" (PDF). Government Digital Service. p. 12. Retrieved January 1, 2020.
- BGS International BG04352543
- ChemIDplus 003270028
- ChemIDplus 063938249
- DiscoveryGate 201111
- EPA DSSTox DTXCID30108861
- FDA UNII - NLM R224WJZ8M7
- FDA UNII - NLM UNII: R224WJZ8M7
- iChemical EBD155042
- LeadScope LS-64327
- MassBank JP003742
- Molport MolPort-046-762-794
- PubChem 201111
- Wikidata Q4032934
- Wikipedia ALD-52
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- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
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