Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.
Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.
Practice Harm Reduction. Proceed with Caution.
Also known as:
ethyl-9,10-didehydr[German][ACD/IUPAC Name] oergolin-8-carboxam id
ethyl-9,10-didehydr[ACD/IUPAC Name] oergoline-8-carboxa mide
éthyl-9,10-didéhydr[French][ACD/IUPAC Name] oergoline-8-carboxa mide
(prop-2-en-1-yl)-9, 10-didehydroergolin e-8-carboxamide
ide, 9,10-didehydro[ACD/Index Name] -N,N-diethyl-6-(2-p ropen-1-yl)-, (8β)-
ACID N,N-DIETHYLAMI DE
N-diethyl-6,6a,8,9-[ACD/IUPAC Name] tetrahydro-4H-indol [4,3-fg]quinoline-9 -carboxyamine
l-7-prop-2-enyl-6,6 a,8,9-tetrahydro-4H -indolo[4,3-fg]quin oline-9-carboxamide
9-hexahydro-indolo[ 4,3-fg]quinoline-9- carboxylic acid die thylamide
sergic acid diethyl amide
AL-LAD is a hallucinogenic drug, lysergamide and an analogue of LSD. It is reported as having some subtle experiential differences to LSD (such as increased visuals), and also appears to be slightly shorter lasting. AL-LAD doses are similar to those of LSD, depending on purity. Its availability on the Internet since 2013 has lead to strong popularity among the drug community.
AL-LAD is chemically similar to LSD and has a similar mechanism of action, working primarily by binding to serotonin receptors in the brain. AL-LAD was first investigated in 1984 by Andrew J. Hoffman and David Nichols as part of a series of LSD analogs, which also included ETH-LAD and PRO-LAD.
Its activity in humans was later documented by Alexander Shulgin in his book TiHKAL (“Tryptamines I Have Known and Loved”), in which it is described as “considerably less dramatic”. In 2013, AL-LAD appeared for sale on the research chemical market, where it has been commonly marketed alongside lysergamides such as 1P-LSD, ALD-52 and ETH-LAD as a legal, grey-market alternative to LSD. User reports describe the effects of AL-LAD as similar to those of LSD with some subtle differences.
It is thought to either be equally or moderately less potent than LSD itself, with an active dose reported at between 75 and 150 micrograms. It is often described as being more visually-oriented but with a less introspective headspace. It also has a moderately shorter duration and is generally considered to be a less anxiety-provoking and challenging version of LSD.
Very little data exists about the pharmacological properties, metabolism, and toxicity of AL-LAD. While it is often characterized by users as being generally more recreational and non-threatening compared to LSD, it is highly advised to approach this highly potent hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.
AL-LAD is a structural analog of lysergic acid, with an N,N-diethylamide functional group bound to RN of the chemical structure.
AL-LAD’s chemical structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (nor-lysergic acid).
Unlike LSD, AL-LAD does not contain a methyl group substituted at R6 of its nor-lysergic acid skeleton, this is represented by the nor- prefix.
Instead, AL-LAD is substituted at R6 with an allyl group comprised of a methylene bridge bound to a vinyl substituent.
At carbon 8 of the quinoline a N,N-diethyl carboxamide is bound. AL-LAD is a chiral compound with two stereocenters at R5 and R8.
AL-LAD, also called (+)-D-AL-LAD, has an absolute configuration of (5R, 8R).
The three other stereoisomers of AL-LAD do not have psychoactive properties.
|Common Name||N-ALLYLNORLYSERGIC ACID N,N-DIETHYLAMIDE|
|Systematic name||N-ALLYLNORLYSERGIC ACID N,N-DI|
|SMILES||CCN(CC)C(=O)[[email protected]]1CN([[email protected]@H]2Cc3c[nH]c4c3c(ccc4)C2=C1)CC=C|
|Avg. Mass||349.4693 Da|
|Monoisotopic Mass||349.215424 Da|
|AL-LAD Duration Data|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Effects||Similar in effect to LSD, open and closed eye visuals are common. Auditory hallucinations are reported as common. A sense of connectedness with people and the environment around you. A strong sense of wellbeing.|
|Marguis Test Result|
AL-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from AL-LAD’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation. AL-LAD shares many common traits with its parent compound LSD; in humans it appears to be roughly equal (if slightly less) in potency as well as similar in mechanism although the progression and duration of effects are compressed (while remaining qualitatively less intense and more manageable - perhaps due to being catabolised more readily). In rats, however, AL-LAD was measured to be around twice the potency of LSD, although anecdotal reports by humans have reported to be about equipotent if not slightly less potently psychoactive as LSD.
While its subjective effects largely overlap with those of LSD, AL-LAD is commonly reported to be significantly shorter in its duration and less uncomfortable in both its negative physical side effects and general anxiety. Some users have proposed that this compound could potentially serve as an effective introductory psychedelic, alongside other shorter-lasting and manageable psychedelics like 2C-B or 4-HO-MET.
- Stimulation - In terms of its effects on the physical energy levels of the user, AL-LAD is regarded as being able primarily stimulating in nature in the same vein as LSD. This is in distinction to other, more commonly used psychedelics such as psilocybin which are more consistent in producing sedation and relaxedness.
- Spontaneous bodily sensations - The "body high" of AL-LAD can be described as proportionally intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location specific tingling sensation. For some, it is manifested spontaneously at different unpredictable points throughout the experience, but for most it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. In comparison to LSD, it is a little less sharp in the tingling sensations it produces as but is otherwise essentially indistinguishable.
- Perception of bodily lightness - This component typically accompanies any feelings of stimulation that this compound can produce.
- Physical euphoria - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason.
- Changes in felt bodily form - This effect is often accompanied by a sense of warmth or unity and usually occurs during and up to the peak of the experience or directly afterward. Users can feel as if they are physically part of or conjoined with other objects. This is usually reported as feeling comfortable and peaceful in its sensations.
- Tactile enhancement - Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most AL-LAD trips. If level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once becomes consistently present.
- Temperature regulation suppression - This component can occur with the use of any lysergamide or psychedelic, but reports suggest it may be pronounced in AL-LAD. It is highly advised that users of this compound, especially at heavier doses, monitor their bodily temperature and use techniques like hot showers or cold packs to regulate their core and brain temperature throughout the experience, and to generally always maintain proximity to a climate-controlled environment.
- Increased bodily temperature
- Nausea - Mild nausea is occasionally reported when this substance is consumed in moderate to high dosages, usually during the peak, and either passes soon after the user has vomited or gradually fades by itself as the peak sets in.
- Stamina enhancement - This is generally mild in comparison to traditional stimulants.
- Bodily control enhancement
- Appetite suppression
- Difficulty urinating
- Increased blood pressure
- Increased heart rate
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Increased libido
- Excessive yawning - This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
- Pupil dilation
- Increased salivation
- Seizure - This is an effect whose likelihood is largely extrapolated from the seizures that have been reported from the use of LSD. They are thought to mainly be a risk in those who are genetically predisposed to them, particularly while accompanied by physically taxing conditions such as dehydration, fatigue or undernourishment.
In comparison to other psychedelics such as psilocin, LSA and ayahuasca, AL-LAD is significantly more stimulating and fast-paced in terms of the specific style of thought stream which it produces and contains a large number of potential effects associated with both psychedelic tryptamines and phenethylamines. In comparison to LSD, it is often reported to be less anxiety-provoking and generally more emotionally comfortable and forgiving. The most prominent of these cognitive effects generally include:
- Analysis enhancement - This effect is consistent in its manifestation and outrospection dominant.
- Conceptual thinking
- Cognitive euphoria - This component is, generally speaking less consistent and pronounced than it is with substances like psilocybin and MDMA. The mental euphoria experienced on AL-LAD is usually simply due to an enhancement of the user’s current psychological and emotional state coupled with its more regularly occurring effect, physical euphoria.
- Novelty enhancement
- Immersion enhancement
- Focus enhancement - This effect is experienced exclusively on low or threshold dosages and feels less forced than it does with stimulants.
- Immersion enhancement
- Motivation enhancement
- Emotion enhancement
- Increased music appreciation
- Increased sense of humor
- Memory suppression
- Time distortion
- Déjà vu
- Thought acceleration
- Thought loops
- Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed yet cartoon-like in appearance. The distortions are slow and smooth in motion and fleeting in their appearance. This is nearly identical in appearance to the visual drifting which occurs under the influence of LSD.
- After images
- Colour shifting
- Depth perception distortions
- Scenery slicing
- Symmetrical texture repetition
The visual geometry evoked by AL-LAD can be described as more similar in appearance to that of LSD, 2C-B or 4-HO-MET than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful and cartoonish in scheme, organic in feel, flat in shading, soft in its edges, large in size, slow in speed, smooth in motion, either angular or round in its corners, non-immersive in-depth and consistent in intensity. At higher dosages, it consistently results in states of Level 8B visual geometry over Level 8A.
In comparison to LSD specifically, AL-LAD's geometry tends to be more rounded in its corners, slightly softer in its edges, warmer in hue, and slightly less intricate in its form. Aside from this, it is otherwise identical in its appearance.
AL-LAD is capable of producing a full range of low and high level hallucinatory states in a fashion that is a less consistent and reproducible than that of many other commonly used psychedelics such as psilocin or DMT but considerably more likely to when compared to that of LSD. This can feel similar to the hallucinations which occur with 4-AcO-DMT but tends to occur almost exclusively at heavier doses. Some of these effects include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and occasionally of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
- Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
- Existential self-realization
- Perception of eternalism
- Perception of self-design
- Perception of interdependent opposites
- Unity and interconnectedness
AL-LAD is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries, but people may still be charged for its possession under certain circumstances such as under analog laws and with the intent to sell or consume.
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