9 Facts About LSD Everyone Should Know

9 Important Facts To Know About LSD

9 Facts About LSD Everyone Should Know

Table Of Contents

Out of the Ergot fungus which grows on Rye, comes a psychedelic called LSD or lysergic acid diethylamide. LSD is most popularly known as being the drug of choice during the 1960s counterculture.

The Swiss scientist Albert Hofmann, in 1938, developed LSD during the research on preventing post-partum bleeding, which was the leading killer of women during childbirth. It sat on his shelf for years, until he accidentally ingested a bit of LSD through his skin, and thus were discovered the hallucinogen properties of this drug.1

I suddenly became strangely inebriated. The external world became changed as in a dream. Objects appeared to gain in relief; they assumed unusual dimensions; and colors became more glowing. Even self-perception and the sense of time were changed. When the eyes were closed, colored pictures flashed past in a quickly changing kaleidoscope. After a few hours, the not unpleasant inebriation, which had been experienced while I was fully conscious, disappeared. what had caused this condition?

Dr. Albert Hofmann, author of LSD: My Problem Child

Buy a copy of LSD My Problem Child: Reflections on Sacred Drugs, Mysticism and Science from Amazon.

Or read for free at the Psychedelic Library2

Since it was the twenty-fifth in a series of lysergamide derivatives, its official name became LSD-25.

LSD is an extremely powerful hallucinogen, and has immense therapeutic, spiritual and cultural transformative potential.

LSD Facts

LSD is an amazing psychedelic drug. It is a favorite of many psychedelic explorers.

LSD promotes neuroplasticity and neural connection growth in the brain.3

There are a few key facts about LSD which are not very well known. Here are some important LSD drug facts such as addiction potential, psychotherapy use, historical time line, and chemical moeity that everyone should know about.

  1. LSD is one of the most powerful hallucinogenic drugs known. It requires only 100ug (smaller than a grain of salt) to produce profound psychological effects.45

  2. LSD was used by the US government for project MKUltra, also known as the CIA mind control program.

  3. The trip length of LSD is between 6 and 12 hours. It takes 30-60 minutes to kick in and another 30 minutes for the come up.6

  4. LSD is not only a serotonergic agonist, meaning that it not only targets the serotonin recpetors like the neurochemical “Serotonin”, it is also a potent Dopamine D2 receptor agonist and a partial antagonist.7

  5. Unlike its serotonergic agonism, which creates higher concentrations of 5-Hydroxy Tryptamine in the brain, LSD with its dopaminergic agonism does not increase dopamine concentrations in the brain, which makes LSD physically non-addictive. Dopamine controls the reward circuitry of the brain.8

  6. LSD is chemically active, at the level of the brain, at the microgram dosage, making it the strongest psychedelic available to man weight for weight. The only one compound stronger than LSD is Salvinorin-A found in the Salvia Divinorum plant, which at 250ug is as potent (or more) than DMT itself, one of the strongest hallucinogens known to man.

  7. The only thing stronger than LSD, DMT, and Salvinorin-A is the newly developed Salvinorin-B Ethoxy-Methyl-Ether.9 Salvinorin-B is 10 times more potent than Salvinorin-A, making it around 10-15 times more potent than LSD.

  8. Some of the most well-known philosophers, artists, and tech gurus like Steve Jobs, Cary Grant, John Lennon, Aldus Huxley, and George Harrison from the Beatles, the famous comedians Cheech Marin, Tommy Chong, and George Carlin have taken LSD.10

  9. LSD, however, in some cases, has the potential to cause psychological issues, espeically in people with psychosis and schizophrenia or a family history of mental illness. LSD may actually exacerbate these conditions.11

What is LSD?

Lysergic Acid diethylamide, known as LSD, is a potent psychedelic among the most intense psychedelic drugs out there. It is a medication of extraordinary unconventionality, and is prohibited for use in the United States, as well as many other countries, despite the fact that it was once utilized as a mental health therapy, by the US government, and to induce labor in pregnant women. 12

Many people utilize LSD as a major aspect of contemplation in order to understand the nature of consciousness and reality. Albert Hofmann was interested in developing medicines from compounds in ergot, known as ergotamines, fungi that are born on rye. He then accidentally ingested some LSD through his skin. Dr. Hofmann wrote about this in his book LSD: My Problem Child.

Many plants in nature including Morning Glory seeds, and Hawaiian Baby Wood rose seeds contain LSA, which is Lysergic Acid Amide. It differs from LSD in that LSD is “Di Ethyl Amide” meaning that it has two Ethyl Amides on the molecule, which make is much cleaner than LSA. The LSD trip is much less nauseaus, lasts a little longer, and doesn’t produce a heavy body load as compared to LSA.13

LSD is derived from the Ergot Fungus

Even though LSD is purely synthetic, its biological history can be traced by looking at the history of the ergot fungus from which it was derived.

Many plants, grasses, beans, and legumes of the “cereal” type, as well as rye and wheat, among others, can become infected by these fungi during moist and humid conditions. These fungi are known to produce compounds which are called sclerotia.

Sclerotia produce various type of ergot based alkaloids, such as ergometrine, ergocornine, ergotamine, ergocristine, ergocryptine and ergosine.

The ergot alkaloids have been used by humans for a long time for psychedelic introspection, although their use came with a heavy price, such as ergot poisoning.

Convulsive ergotism (ergot poisoning) attacks the central and the peripheral nervous systems, causing mania, psychosis, hallucinations, paralysis and tingling sensations.14

When was LSD Made?

LSD was first made in 1938 by Dr. Albert Hofmann. He made it by utilizing ergot. Ergot is a parasite that develops on grains, particularly rye. The LSD was integrated and after that self-tried.

Initially, it was believed that the medication could be utilized to help with the induction of labor in pregnant women. Be that as it may, once it ended up clear that LSD influenced state of mind and delivered mental impacts, it was promoted as a mental and restorative medication.

LSD’s fundamental potential was thought to enhance the human mind. This is why the US Gov. researched it, beleiving it could help the armed forces.

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How to take LSD?

LSD is frequently taken in tab shape. It can be found on blotting surface paper called blotter tabs. LSD can be liquid too. LSD has no taste, and it doesn’t smell. This makes it difficult to recognize.

It does, in any case, have a chemical reaction with Ehrlic’s Test, and turn purple when tested. LSD can be rarely be absorbed through the skin, taken orally, infused or even taken through the eyes in eye-dropper form.

LSD Timeline

  1. Invented in 1938 by Dr. Albert Hofmann, a Swiss chemist.

  2. Stimulating and Psychedelic properties found in 1943.

  3. Found by the American Psychiatric Agencies in the 1950s.

  4. Generally utilized as a part of psychotherapy and addiction treatment all through the 60s.

  5. Deeply affected the counterculture of the 1960s, producing great musicians, artists, and authors.

  6. Proclaimed an illicit medication in 1968. All related treatment and exploratory studies stopped due to the US gov.

  7. Utilized by at millions of Americans and Europeans all through the 70s, 80s, and 90s, continuing to this day.

  8. A invigorated renewal of enthusiasm in modern day psychotherapy by the cutting edge psychiatrists in psychedelic psychotherapy.

Historical facts about LSD

Research conducted by psychiatrists and psychologists during the 60’s and 70’s clearly showcased that there was a considerable psychological risk with using the psychedelic drug. High doses, especially in unsafe or inappropriate settings, caused panic reactions very often, causing the individuals to run and/or become extremely agitated or frightened.

For individuals who have a low threshold for schizophrenia, psychosis, and other mental conditions, a LSD trip turned bad could be the triggering event for the onset of full-blown psychosis and other other psychiatric conditions. Research on potential therapeutic uses of LSD was banned by the United States government because of political reasons in the mid-1970s.15

Public Safety or Mass Control?

Psychedelics are illegal not because a loving government is concerned that you may jump out of a third story window. Psychedelics are illegal because they dissolve opinion structures and culturally laid down models of behavior and information processing. They open you up to the possibility that everything you know is wrong.

Though, is that really why? Terence McKenna is known for having popularly said that LSD, and other psychedelics are not banned because a loving and caring government wants to keep you safe. And I think Dr. McKenna may be onto something here because accidents caused by psychedelics are much less on average than those caused by other popular and legal substances.

Most currently legal are far more dangerous to our health than psychedelics or plant medicines could ever be. If the governments really cared out the lives of its citizens, them? That seems only logical because the worst killers of human population after obesity are drinking and smoking.1617

LSD addiction & Safety facts

LSD does not increase levels of dopamine in the brain, thus it is not physically addictive. In fact, LSD was actually used to treat addiction to drinking, smoking, and hard drug addiction.

So why was LSD banned (made illegal)?

A basic fact about LSD is that it is actually relatively non-toxic and does not cause addiction, however, many governments around the world banned it’s manufacturing and consumption it after a number of fatal accidents were reported.

These accidents involved people, under the influence of LSD, thinking that they could fly, jumped to their deaths off tall buildings, trees, and windows.

Some people became paranoid and shot or stabbed their friens and/or family. Some people with a low threshold for psychosis exhibited dangerous behaviors. 18

Moiety of LSD

What is Moiety?

In organic chemistry, moiety is a part of a chemical molecule can be found within other kinds of molecules as well. The moiety of an acetyl group can be found in many organic compounds, such as: including acetic acid, acetylcholine, acetyl-CoA, acetylcysteine, acetaminophen. 19

Moieties and functional groups may also contain smaller moieties, or themselves be contained within a larger moiety. Methyl p-hydroxybenzoate contains a phenol functional group within the acyl moiety, which in turn is part of the paraben moiety. Larger moieties are often functional groups.20

A fragment of a molecule that can also be found in another molecule.21

The Moiety of LSD (Serotonin and Dopamine)

LSD is one of a kind in psychedelic molecules. The most amazing thing about LSD is that it contains the moiety of both Serotonin and Dopamine! 22


Serotonin is one of the most important neurotransmitters produced by the human body. Most of our nervous system functions on serotonin. It is known as the neurotransmitter which regulates our moods, psychological states of mind, muscle movement, blood flow, and gastric system. 23

This is the shape of the Serotonin molecule

This is the shape of the Serotonin molecule

80% to 90% of the serotonin is located in the enterochromaffin cells that are found in the gastrointestinal tract. Serotonin plays an important part in regulating the gastrointestinal movements.

After it has been secreted by the enterochromaffin cells, serotonin pours from these tissues and gets absorbed and stored in the blood platelets. The next highest concentration of Serotonin is found in the muscular system, where it regulates muscle movement and blood flow to the muscles. 24

Lastly, the rest of the serotonin is found in the brain where its function is to regulate mood, feelings, emotions, and sleep. Serotonin also keeps track of our social status, and like the lobsters, we use serotonin to find and determine our place in the social hierarchy of human beings.25


Dopamine is a very important neurotransmitter. It is the one chemical which is responsible for transmitting signals in between the neurons of the brain and manages the reward circuitry of the brain. Not many neurons actually make dopamine.26

This is what the Dopamine molecule looks like.

This is what the Dopamine molecule looks like.

Dopamine is important as it functions to improve the pumping strength of the heart muscle and increases blood flow to the kidneys. Dopamine is used to treat psychological conditions which occur when the organism is in shock, astonishment, fear, happiness, and success. 2728

Dopamine knows to either reward or punish the nervous system which allows the organism to learn how to function healthily in the world.

LSD Contains Serotonin & Dopamine Structures

Most people do not know or realize that LSD not only functions across the 5HT (5-Hydroxy Tryptamine) Serotonin receptors in the brain, but also stimulates the Dopamine D2 receptors. 29

LSD contains the molecular shape and structure of serotonin!

LSD contains the molecular shape and structure of serotonin!

Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors which potentiate the serotonergic agonism. 30

LSD is not only an agonist of the D2 Dopamine receptors, it also acts as a partial antagonist.

LSD contains the molecular shape and structure of dopamine!

LSD contains the molecular shape and structure of dopamine!

According to a pubmed study Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro:

“The hallucinogenic effects of lysergic acid diethylamide (LSD) have mainly been attributed to the interaction of this drug with the serotonergic system, but it seems more likely that they are the result of the complex interactions of the drug with both the serotonergic and dopaminergic systems.”

According to Research Gate31:

“[…] investigations suggest that the hallucinogenic actions of LSD may be due to complex agonist and antagonist actions of this drug at central receptors for the several neurotransmitter mono amines.”


  1. History of LSD [return]
  2. The Psychedelic Library [return]
  3. LSD increases neuroplasticity [return]
  4. One Of The Most Shocking Cia Programs Of All Time: Project Mkultra [return]
  5. The Cia’S Appalling Human Experiments With Mind Control [return]
  6. Lysergic Acid Diethylamide: Psychonautwiki [return]
  7. Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine [return]
  8. Neuropsychopharmacology: Modern Clinical Research on LSD [return]
  9. Salvinorin-B Ethoxy-Methyl-Ether.) [return]
  10. Famous People Who Used LSD [return]
  11. LSD Psychosis or LSD-Induced Schizophrenia? [return]
  12. LSD: Legal status [return]
  13. LSA Basics: by Erowid [return]
  14. School of Chemistry University of Bristol: Lysergic Acid Diethylamide - LSD [return]
  15. A brief history of psychedelic psychiatry [return]
  16. Tobacco-Related Mortality [return]
  17. Drinking Facts and Statistics [return]
  18. How the hazards of LSD were augmented, 1962-1969 [return]
  19. Structure of LSD and Its Receptor Explains Its Potency [return]
  20. Moiety (chemistry) [return]
  21. Illustrated Glossary of Organic Chemistry [return]
  22. LSD Structure and Its Receptor Explains Its Potency [return]
  23. What is Serotonin [return]
  24. Integrative Psychiatry: Serotonin [return]
  25. Medical News Today: Serotonin Facts [return]
  26. What Is Dopamine? [return]
  27. Psychology Today: What is Dopamine [return]
  28. Wikipedia: What is Dopamine [return]
  29. Dopamine Receptor: D2 [return]
  30. LSD as an agonist and antagonist at central dopamine receptors [return]
  31. Research Gate: LSD Dopamine Receptor Agonist [return]