Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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DOC Also known as:

  • 1-(4-Chlor-2,5-dimethoxyphenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(4-Chloro-2,5-dimethoxyphenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(4-Chloro-2,5-diméthoxyphényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(4-chloro-2,5-dimethoxyphenyl)propan-2-amine
  • 2,5-dimethoxy-4-chloroamphetamine
  • 4-chloro-2,5-dimethoxyamphetamine
  • Benzeneethanamine, 4-chloro-2,5-dimethoxy-α-methyl-[ACD/Index Name]
  • DOC
  • 1- (4-chloro-2,5-dimethoxyphenyl) propan-2-amine[ACD/IUPAC Name]
  • '123431-31-2
  • 2-(4-Chloro-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • 4-Chloro-2,5-Dimethoxyamphetamine (''DOC'') - from SFL5
  • amphetamine, 4-chloro-2,5-dimethoxy-
  • MFCD12964184[MDL number]

A potent stimulating psychedelic with a long action, a phenethylamine and substituted amphetamine. Sometimes sold as LSD but also enjoyed on its own merits by many. Usually sold on blotters slightly larger than those LSD is found on, but can also be bought in powder form.


It is a member of the DOx family of psychedelic amphetamines, which are known for their long duration and mixture of psychedelic and stimulant effects. DOC was first synthesized by a team at the University of Alberta in 1972. However, its usage in humans was not popularized until the 1991 publication PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin.

Preceding this, a 1989 forensic analysis of designer amphetamine samples identified DOC in Canadian drug seizures. DOC is known as a highly dose-sensitive psychedelic that is often sold in powder form or on blotting paper and known for its long duration (over 12-24 hours), strong visual effects, a unique form of stimulation, and a significant body load. Along with its sensitive dose-response and unusually long duration, many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with hallucinogens.

Therefore it is highly advised to approach this unusually dose-sensitive, and long-lasting psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.


DOC was first synthesized by 1972 by Ronald Coutts and Jerry Malicky at the University of Alberta. While human usage was popularized by the 1991 publication of its synthesis and pharmacology in PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin, a 1989 forensic analysis of designer amphetamine samples identified DOC in Canadian drug seizures.




Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα.

DOC contains methoxy functional groups OCH3 attached to carbons R2 and R5 and a chlorine atom attached to carbon R4 of the phenyl ring.

DOC is the amphetamine analogue of the phenethylamine 2C-C.

Common Name4-chloro-2,5-dimethoxyamphetamine
Systematic name4-chloro-2,5-dimethoxyamphetamine
Std. InChiInChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1
Avg. Mass229.7032 Da
Molecular Weight229.7032
Monoisotopic Mass229.08696 Da
Nominal Mass229
ChemSpider ID472008

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Dose Chart


Duration Chart

DOC Duration Data
Onset30-150 minutes
Duration10-20 hours
After-effects6-12 hours



  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

Auditory Effects

Psychological Effects

The cognitive effects of DOC are described by many as characterized as prominent mental stimulation combined with a powerful amplification of the user's current mental state. The total sum of these cognitive components regardless of the setting generally includes:

  • Anxiety & Paranoia - This effect is not as common at low to moderate doses and is less likely to occur when the basic rules of set and setting are taken into account. It should be noted that this inconsistently induced effect is seemingly more likely to manifest when used with cannabis. This combination should be used with extreme caution if one is not experienced with psychedelics, meaning that the user should adequately pace themselves with a fraction of their usual amount. It is commonly reported that psychedelics can to a certain extent counteract some of the perceived mental cloudiness or intoxicating effects of THC causing the user to in turn use more cannabis than is needed which can often lead to an overwhelmingly anxious and paranoid headspace which can trigger a "bad trip".
  • Conceptual thinking
  • Thought acceleration
  • Thought connectivity
  • Empathy, affection, and sociability enhancement - This component is typically manifested only in the context of social settings in which one is within the company of others, and only at lower, non-impairing doses. These feelings of sociability, affection, and empathy tend to be weaker and less consistent than those produced by substances such as MDMA and 2C-B, but can still prove strong enough to provide long-lasting therapeutic effects.
  • Cognitive euphoria
  • Analysis enhancement - This effect is consistent in its manifestation and outrospection dominant.
  • Novelty enhancement
  • Immersion enhancement
  • Emotion enhancement
  • Increased music appreciation
  • Increased sense of humor
    • Laughter fits - This can manifest prominently during a DOC experience, particularly during the come up phase, often resulting in bouts of uncontrollable giggles and laughter that can form a feedback loop if around others who are also under the influence.
  • Memory suppression
    • Ego death - While DOC is technically able to produce states of ego dissolution, it tends to more often than not develop only in extremely high doses, with grave physical and mental side effects being apparent and is often of a terrifying nature.
  • Increased libido
  • Time distortion
  • Wakefulness

Pharmacological Effects

DOC’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Physical Effects

  • Stimulation - DOC is usually reported to be extremely stimulating at levels which are capable of becoming uncomfortable and overwhelming. This can result in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed. The type of stimulation is generally encouraged but can also present some forcefulness to it.
  • Spontaneous bodily sensations - The "body high" of DOC is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
    • Physical euphoria - It should be noted that this effect is not as reliably induced as it is with substances like stimulants or entactogens, and can just as easily manifest as physical discomfort without any apparent reason. DOC and other psychedelic amphetamines tend to lean towards physical dysphoria more so than other psychedelics.
  • Changes in felt bodily form
  • Bodily control enhancement
  • Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at low to moderate levels throughout most DOC experiences.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
  • Vasoconstriction - This effect is usually only present at higher dosages, but can be particularly uncomfortable when it manifests, and may persist throughout as well as after the main duration of the experience.
  • Increased blood pressure
  • Increased heart rate
  • Appetite suppression
  • Increased perspiration
  • Muscle contractions
  • Muscle spasms
  • Muscle cramps
  • Difficulty urinating
  • Dehydration
  • Dry mouth
  • Temperature regulation suppression - This effect is more prominent than it is with other psychedelics like LSD.
  • Diarrhea
  • Teeth grinding
  • Restless legs
  • Pupil dilation
  • Increased salivation
  • Seizure - This is a rarely observed effect but is known to happen in those who are presumably predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or generally fatigued.

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience for those who are already predisposed to synaesthetic states.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Visual Effects

The visuals of DOC are commonly described as being very simplistic, cartoon-like and linear, when compared to DOB or LSD.




The visual geometry encountered on DOC can be described as more similar in appearance to that of mescaline than that of ayahuasca, psilocybin mushrooms or LSD. It can be comprehensively described through its variations as intricate in complexity, abstract in form, synthetic in feel, structured in organization, brightly lit, multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in depth and consistent in intensity. At higher dosages, this geometry is significantly more likely to result in states of level 8B visual geometry over level 8A.

Hallucinatory states

DOC and other substituted amphetamines produce a full range of high-level hallucinatory states in a fashion that is more or less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

Legal Status

  • Austria: DOC is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: DOC is Schedule I in Canada, making it illegal to sell, buy, or possess, without a valid legal exemption.
  • China: As of October 2015 DOC is a controlled substance in China.
  • Denmark: DOC is a Schedule I drug in Denmark.
  • Finland: DOC is illegal to possess, produce and sell in Finland.
  • Germany: DOC is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of February 1, 1997. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Israel: The possession, production and sale is illegal.
  • Latvia: DOC is a Schedule I controlled substance.
  • New Zealand: DOC is a Class C drug in New Zealand.
  • United Kingdom: DOC is considered a Class A drug as a result of the amphetamine analogue clause of the Misuse of Drugs Act 1971.
  • United States: DOC is technically not scheduled in the United States, but could be considered an analogue of DOM or DOB and may therefore be considered a Schedule I drug under the Federal Analogue Act.
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    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

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