Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

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Description

25C-NBOMe Also known as:

  • 2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Chlor-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Chloro-2,5-diméthoxyphényl)-N-(2-méthoxybenzyl)éthanamine[French][ACD/IUPAC Name]
  • 4-CHLORO-2,5-DIMETHOXY-N-(2-METHOXYBENZYL)PHENETHYLAMINE
  • 9FGW3C260N
  • Benzeneethanamine, 4-chloro-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-[ACD/Index Name]
  • N-(2-Methoxybenzyl)-2-(4-chloro-2,5-dimethoxyphenyl)ethanamine
  • [2-(4-Chloro-2,5-dimethoxy-phenyl)-ethyl]-(2-methoxy-benzyl)-amine
  • [2-(4-chloro-2,5-dimethoxyphenyl)ethyl][(2-methoxyphenyl)methyl]amine
  • 2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethan-1-amine
  • 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
  • 25C-NBOMe
  • MFCD16659701[MDL number]
  • UNII:9FGW3C260N
  • UNII-9FGW3C260N

A relatively new and popular research chemical. A short acting psychedelic related to 2C-C with similar effects to LSD, though more visual with less of a ‘head-trip.’ Frequently mis-sold as LSD. Causes an uncomfortable body load and has caused several deaths even within regular dose ranges.

Summary

It is a member of the 25x-NBOMe series, a recently discovered group of potent psychedelic compounds derived from the 2C-x family. The name 25C-NBOMe, which is short-hand for 2C-C-NBOMe, is a derivative of the phenethylamine psychedelic 2C-C. It was discovered in 2003 by Ralf Heim at the Free University of Berlin, and subsequently investigated by a team at Purdue University led by David Nichols.

It has been studied in its radiolabelled form as a potential ligand for mapping the distribution of serotonin-2A receptors in the brain using positron emission tomography (PET). The first reports of human use appeared in 2010 following its appearance on the online research chemical market. Subjective effects include stimulation, open and closed-eye visuals, time distortion, euphoria, and ego loss.

25C-NBOMe’s effects are sometimes compared to those of LSD or DOx. However, it is reported to have stronger visual effects and less cognitive and emotional effects like ego loss and introspection. Additionally, 25C-NBOMe is reported to be considerably more stimulating than other psychedelics.

Serious side effects are more common and include nausea, muscle tension, anxiety, cardiovascular effects, and seizures. It is worth noting that members of the NBOMe series are not orally active and should be administered sublingually (by holding it into one’s mouth and allowing it to absorb over a period of 15 minutes). 25C-NBOMe can also be vaporized and inhaled for more rapid and powerful effects and a shorter duration.

However, this route of administration is highly advised against due to the difficulties of measuring and handling substances that are active in the microgram range as it significantly increases the risk of overdose. 25C-NBOMe is also sometimes sold as a counterfeit version of LSD due to its similar effects and ability to be laid onto blotter paper. Very little is known about the pharmacological properties, metabolism, and toxicity of 25C-NBOMe.

However, it has been associated with many deaths and hospitalizations which suggests that it has a significantly worse toxicity profile than classical psychedelics like LSD or psilocybin mushrooms. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. It is highly advised to use harm reduction practices if using this substance.

Chemistry

25C-NBOMe

25C-NBOMe

25C-NBOMe is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as a chlorine atom attached to carbon R4.

It differs from 2C-C structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group as shown in the image to the right.

25C-NBOMe shares this 2-methoxybenzyl substitution with other chemicals of the NBOMe family.

This NBOMe addition contains a methoxy ether CH3O- bound to a benzene ring at R2.

Common Name2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine
Systematic name2-(4-Chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine
FormulaC_{18}H_{22}ClNO_{3}
SMILESCOc1ccccc1CNCCc2cc(c(cc2OC)Cl)OC
Std. InChiInChI=1S/C18H22ClNO3/c1-21-16-7-5-4-6-14(16)12-20-9-8-13-10-18(23-3)15(19)11-17(13)22-2/h4-7,10-11,20H,8-9,12H2,1-3H3
Std. InChiKeyFJFPOGCVVLUYAQ-UHFFFAOYSA-N
Avg. Mass335.8252 Da
Molecular Weight335.8252
Monoisotopic Mass335.128815 Da
Nominal Mass335
ChemSpider ID24583389

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Dose Chart

Sublingual
Threshold50-250ug
Light250-500ug
Common500-750ug
Strong750-1250ug+

Duration Chart

25C-NBOMe Duration Data
Onset45-90 minutes
Duration4-10 hours
After-effects1-24 hours

Legal Status

  • Austria: Since June 26, 2019, 25C-NBOMe is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 25C-NBOMe would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: As of October 2015 25C-NBOMe is a controlled substance in China.
  • Germany: 25C-NBOMe is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Israel: The NBOMe series of psychoactives became controlled in Israel in May, 2013.
  • Italy: 25C-NBOMe is a Schedule 1 controlled substance in Italy, meaning it is illegal to possess, distribute, and manufacture.
  • Latvia: 25C-NBOMe is a Schedule I controlled substance.
  • New Zealand: 25C-NBOMe was sold as a designer drug in New Zealand in early 2012, but was withdrawn from sale after a statement by Associate Health Minister Peter Dunne that 25C-NBOMe would be considered to be substantially similar in chemical structure to the illegal hallucinogen DOB, and was therefore a Class C controlled drug analogue.
  • Russia: Russia became the first country to regulate the NBOME class. The entire NBOMe series of psychoactives became controlled in the Russian Federation starting October, 2011.
  • Sweden: 25C-NBOMe is classed as Schedule I.
  • United Kingdom: 25C-NBOMe is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.
  • United States: Several NBOMe series compounds will be temporarily scheduled in the United States for 2 years with the possibility of an additional year. The temporary scheduling applies to 25C-NBOMe, 25B-NBOMe, and 25I-NBOMe.
  • Sources

    References

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    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.