Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

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Description

4-HO-MET Also known as:

  • 1H-Indol-4-ol, 3-[2-(ethylmethylamino)ethyl]-[ACD/Index Name]
  • 3-[2-(Ethyl-methyl-amino)-ethyl]-1H-indol-4-ol
  • 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-{2-[Éthyl(méthyl)amino]éthyl}-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-hydroxy-N-methyl-N-ethyltryptamine
  • 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol
  • 3-(2-(ETHYL-METHYL-AMINO)-ETHYL)-1H-INDOL-4-OL
  • 3-?[2-?(ETHYLMETHYLAMINO)ETHYL]-?1H-?INDOL-?4-?OL
  • 3-[2-(ethylmethylamino)-ethyl]-1h-indol-4-ol
  • 3-[2-(ethylmethylamino)ethyl]-1H-Indol-4-ol
  • 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-4-ol
  • 3-2-ethyl(methyl) amine)ethyl)-1 H-indole-4-ol[ACD/IUPAC Name]
  • 4-HO-MET
  • 4-hydroxy MET
  • '77872-41-4
  • MFCD09032995[MDL number]
  • N-Ethyl-4-hydroxy-N-methyltryptamine

A lesser known psychedelic tryptamine. Functional analogue of Psilocin. Very poorly soluble in water and alcohol.

Summary

4-HO-MET is chemically similar to Psilocin, the active ingredient in psilocybin mushrooms ("magic mushrooms"). Like other substituted tryptamines, it produces its psychedelic effects by acting on serotonin receptors in the brain. 4-HO-MET was first synthesized by Alexander Shulgin and reported in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved").

Reports of human use began to surface in the late 2000s following its appearance on the online research chemicals market. It has been sold alongside other psilocybin analogues such as 4-AcO-DMT and 4-HO-MiPT. User reports typically describe 4-HO-MET as a more recreational version of psilocybin mushrooms or psilocin (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects.

Notable effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocybin but there is no data to support this.

It is highly advised to use harm reduction practices if using this substance.

Chemistry

Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.

It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT).

It is also the 4-hydroxyl analog of the base tryptamine MET.

Common Name4-hydroxy-N-methyl-N-ethyltryptamine
Systematic name4-hydroxy-N-methyl-N-ethyltryptamine
FormulaC_{13}H_{18}N_{2}O
SMILESCCN(C)CCc1c[nH]c2c1c(ccc2)O
Std. InChiInChI=1S/C13H18N2O/c1-3-15(2)8-7-10-9-14-11-5-4-6-12(16)13(10)11/h4-6,9,14,16H,3,7-8H2,1-2H3
Std. InChiKeyORWQBKPSGDRPPA-UHFFFAOYSA-N
Avg. Mass218.2948 Da
Molecular Weight218.2948
Monoisotopic Mass218.141907 Da
Nominal Mass218
ChemSpider ID10513072

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Dose Chart

Oral
Light10mg
Common10-15mg
Strong20mg+
Intravenous
Light5mg
Common10-15mg
Strong20mg+

Duration Chart

Oral
Onset5-60 minutes
Duration3-7 hours
After-effects2-8 hours

Legal Status

  • Austria: 4-HO-MET is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Germany: 4-HO-MET is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Sweden: Sveriges Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012.
  • United Kingdom: 4-HO-MET is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
  • United States: 4-HO-MET is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT), a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.

    • Sources

    References

    1. Erowid. (2011). Erowid 4-HO-MET Vault. Retrieved from https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml
    2. http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=21
    3. Rickli A.; Moning O.D.; Hoener M.C.; Liechti M.E. "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens". :10.1016/j.euroneuro.2016.05.001. PMID 27216487.
    4. https://www.erowid.org/chemicals/4_ho_met/4_ho_met_dose.shtml
    5. Täljemark J, Johansson BA. (2012). Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET. Eur Child Adolesc Psychiatry. 21(9), 527-8. doi:10.1007/s00787-012-0282-9
    6. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    7. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    8. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    9. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    10. https://lakemedelsverket.se/upload/lvfs/LVFS_2012_6.pdf
    11. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.