Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.
Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.
This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.
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4-AcO-DMT Also known as:
- 1H-Indol-4-ol, 3-[2
-(dimethylamino)eth[ACD/Index Name] yl]-, acetate (este r)
)ethyl]-1H-indol-4-[ACD/IUPAC Name] yl acetate
)ethyl]-1H-indol-4-[German][ACD/IUPAC Name] yl-acetat
- Acétate de 3-[2-(di
méthylamino)éthyl]-[French][ACD/IUPAC Name] 1H-indol-4-yle
o)ethyl]-1H-indol-4 -yl] acetate
ethyl)-1H-indol-4-y l acetate
)ethyl)-1H-indol-4-[ACD/IUPAC Name] yl-acetate
)ethyl]-1H-indol-4- yl acetate fumarate salt
hyltryptamine free base
hyltryptamine fumar ate
hyltryptamine, free base
- MFCD04279029[MDL number]
)ethyl)-1H-indol-4- yl acetate
A prodrug for Psilocin with extremely similar effects as Mushrooms.
It is a structural analog of psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). Like psilocybin, it is thought to produce its effects primarily by binding to serotonin receptors in the brain; however, the precise mechanism is not fully understood. The synthesis of 4-AcO-DMT was first reported in 1963 by and Franz Troxler as part of an investigation into psilocin analogs.
However, its pharmacology and subjective effects were not explored. A paper authored by David E. Nichols in 1999 proposed it as a potentially useful alternative to psilocybin for pharmacological research due to lower cost of synthesis.
Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s. Subjective effects are reported to be nearly identical to those of psilocybin mushrooms and include geometric visual hallucinations, time distortion, enhanced introspection, euphoria, and ego loss. 4-AcO-DMT is theorized to act as a prodrug to psilocin in a similar manner as psilocybin, which may account for this similarity.
4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users who seek mystical or entheogenic experiences. Very little data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT. While it is believed to have a favorable safety profile similar to that of psilocybin mushrooms (which are known to be physiologically non-toxic) there is currently no data to support this claim.
It is highly advised to use harm reduction practices if using this substance.
4-AcO-DMT and several other esters of psilocin were patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler. However, its pharmacology and subjective effects were not investigated.
It is unknown when 4-AcO-DMT’s effect in humans were first explored.
Tryptamines share a core structure that consists of a bicylic indole heterocycle attached at R3 to a terminal amino group via an ethyl side chain.
4-AcO-DMT is substituted at R4 of its indole heterocycle with an acetoxy (-AcO) functional group CH3COO−.
It also contains two methyl groups CH3- bound to the terminal amine RN of the ethyl side chain. 4-AcO-DMT is the acetate ester analog of psilocin (4-HO-DMT) and the N-substituted methyl homolog of 4-AcO-MET.
It is the O-acetylated form of psilocin, whereas psilocybin is the O-phosphorylated form.
|Avg. Mass||246.3049 Da|
|Monoisotopic Mass||246.136826 Da|
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|4-AcO-DMT Duration Data|
4-AcO-DMT is not listed under any international drug schedules such as the UN Convention on Psychotropic Substances. As a result, it exists in a legal grey area in many countries, meaning that while it is not specifically illegal individuals may still be charged for its possession under certain circumstances such as under analogue laws and with the intent to sell or consume.
- Nichols, D. E., & Frescas, S. (1999). Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin. Synthesis, 1999(6), 935-938.
- US patent 3075992, Hofmann A, Troxler F, "Esters of indoles", assigned to Sandoz Ltd.
- Armstrong, B. D., Paik, E., Chhith, S., Lelievre, V., Waschek, J. A., & Howard, S. G. (2004). Potentiation of (DL)‐3, 4‐methylenedioxymethamphetamine (MDMA)‐induced toxicity by the serotonin 2A receptior partial agonist d‐lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939. Neuroscience Research Communications, 35(2), 83-95. https://doi.org/10.1002/nrc.20023
- Potentiation of MDMA-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists | https://indiana.pure.elsevier.com/en/publications/potentiation-of-34-methylenedioxymethamphetamine-induced-dopamine
- Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons. | https://www.ncbi.nlm.nih.gov/pubmed/17572501
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- "Sechste Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
- 1717 CheMall HE052609
- 1717 CheMall HE194317
- abcr AB464220
- ABI Chemicals AC2A013G8
- AK Scientific Z1701
- AKos AKOS025149599
- Alfa Chemistry 92292-84-7
- Alichem A199011525
- American Custom Chemicals Corp CHM0296982
- Angene AG-A-70925
- Anward ANW-60689
- Ark Pharm, Inc. AK-84418
- Aurora Fine Chemicals A14.515.307
- Aurora Fine Chemicals K18.911.161
- BGS International BG03620650
- BGS International BG04264988
- Biosynth A-0279
- ChemIDplus 92292847
- Chemspace CSC016999246
- eNovation Chemicals K39261
- EPA DSSTox DTXCID80161446
- Erowid 4-Acetoxy-DMT
- FDA UNII - NLM 8BLF220HX1
- Fluorochem 224431
- iChemical EBD4101
- LabNetwork LN01358105
- Letopharm LT08-00350
- Mcule MCULE-3211903653
- Syntharise Chemical SRISEC019
- Tractus Company Limited
- Wikidata Q3491364
- Wikipedia O-Acetylpsilocin
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- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.
Data is constantly updated so please check back later to see if there is any more available information on this substance.