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4-AcO-MET Also known as:

  • 4-Acetoxy-N-methyl-N-ethyltryptamine
  • 1H-Indol-4-ol, 3-[2-(ethylmethylamino)ethyl]-, acetate (ester)[ACD/Index Name]
  • 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-yl acetate[ACD/IUPAC Name]
  • 3-{2-[Ethyl(methyl)amino]ethyl}-1H-indol-4-yl-acetat[German][ACD/IUPAC Name]
  • 4-Acetoxy-MET
  • Acétate de 3-{2-[éthyl(méthyl)amino]éthyl}-1H-indol-4-yle[French][ACD/IUPAC Name]
  • Metacetin
  • PCJ17NV1P0
  • 3-{2-[Ethyl(methyl)amine]ethyl}-1H-indol-4-yl acetate[ACD/IUPAC Name]

A rare psychedelic tryptamine which is thought to be metabolised into 4-HO-MET. Onset and duration, intensity will vary but effect profile is largely the same.




Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-AcO-MET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−.

It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET).

4-AcO-MET is an acetate ester analog of 4-HO-MET and the N-substituted ethyl homolog of 4-AcO-DMT.

Common Name4-Acetoxy-N-methyl-N-ethyltryptamine
Systematic name4-Acetoxy-N-methyl-N-ethyltryptamine
Std. InChiInChI=1S/C15H20N2O2/c1-4-17(3)9-8-12-10-16-13-6-5-7-14(15(12)13)19-11(2)18/h5-7,10,16H,4,8-9H2,1-3H3
Avg. Mass260.3315 Da
Molecular Weight260.3315
Monoisotopic Mass260.152466 Da
Nominal Mass260
ChemSpider ID26633897

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Dose Chart


Duration Chart

4-AcO-MET Duration Data
Onset20-40 minutes
Duration4-6 hours
After-effects2-12 hours

Auditory Effects

Psychological Effects

The cognitive effects of 4-AcO-MET are described by much as somewhat relaxing, yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating. The drug contains a large number of typical and unique psychedelic cognitive effects. The most prominent of these typical effects generally include:

Pharmacological Effects

4-AcO-MET’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. It is also hypothesized that this compound is quickly hydrolyzed into the free phenolic 4-HO-MET, although human studies concerning the metabolic fate of this drug are lacking. This would explain a somewhat similar experience in their subjective effects. This is similar to how 4-AcO-DMT is thought to be deacetylated to 4-HO-DMT during first pass metabolism and subsequent passes through the liver.

Physical Effects

  • Sedation - 4-AcO-MET is considered by most to be relaxing, stoning and mildly sedating. Compulsive yawning often accompanies this sense of sedation. However, the sedation is often considered to be less strong than that of the related compounds psilocin and 4-AcO-DMT.
  • Spontaneous physical sensations - The "body high" of 4-AcO-MET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Changes in felt bodily form - This effect is often accompanied by a sense of warmth and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, though it can also manifest in the form of bodily tension.
  • Muscle contractions - The muscle contractions that can occur by 4-AcO-MET tend to be transient and benign feeling in nature, compared to many other tryptamines, phenethylamines and lysergamides.
  • Muscle relaxation
  • Excessive yawning - This effect seems to be uniquely pronounced among psilocin and related tryptamines. It can occur to a lesser degree on LSD and very rarely on psychedelic phenethylamines like mescaline. It typically occurs in conjunction with watery eyes.
  • Watery eyes
  • Olfactory hallucination
  • Pupil dilation
  • Runny nose
  • Increased salivation
  • Teeth grinding - This component is considerably less intense when compared with substances like MDMA when it occurs.
  • Nausea

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Visual Effects




The visual geometry presented by 4-AcO-MET is similar in appearance to that of psilocin, 4-AcO-DMT and 4-HO-MiPT but with stronger "synthetic" digital undertones comparable to 2C-B. 4-AcO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicolored in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in depth and consistent in intensity. The visuals have a contradictory "synthetic" and "natural" feel to them which is reminiscent of both LSD and psilocybin respectively. Higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

4-AcO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Legal Status

  • Germany: 4-AcO-MET is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • United Kingdom: 4-AcO-MET is a Class A drug in the UK as it is an ester of the drug 4-HO-MET, which is a Class A drug as a result of the tryptamine catch-all clause.
  • United States: 4-AcO-MET is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
  • Sources


    1. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    2. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    3. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    4. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    5. Misuse of Drugs Act 1971 ( |
    6. Misuse of Drugs Act 1971 ( |

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    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

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