Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.
Experimental drugs have extremely limited human consumption data. There is not enough reliable information about this substance. This is most likely because the substance is is not very old. Information on these substances is limite and incomplete. Please be cautioned. Always practice harm reduction.
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Also known as:
Rare drug that is of the tryptamine family, can be comparable to Psilocybin. Expected to quickly hydrolyzed into the free phenolic 4-HO-DET.
There is very little information on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection. Today it is either used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. It remains relatively rare and has very little documented history of human usage.
4-AcO-DET is the acetylated form of 4-HO-DET (also known as ethocin) and is a higher homolog of 4-AcO-DMT and 4-AcO-MET. Like the aforementioned compounds, it is commonly hypothesized to act principally as a prodrug for their respective hydrolyzed counterparts (e. g.
4-HO-DMT, 4-HO-MET and 4-HO-DET). In theory, they would become inactive until they are deacetylated in the body, although there is on-going discussion as to whether they might display their own intrinsic activity.
Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−.
It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (DET). 4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (psilocin).
4-AcO-DET is the acetate ester analog of DET and the N-substituted diethyl analog of 4-AcO-DMT.
|Avg. Mass||298.3795 Da|
|Monoisotopic Mass||298.168121 Da|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Marguis Test Result|
Like with most psychedelic tryptamines, 4-AcO-DET is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-AcO-DET’s binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.
- Sedation and Stimulation - In terms of its effects on the physical energy levels of the user, 4-AcO-DET is typically relaxing, stoning and mildly sedating, although it can also sometimes be very stimulating and give users a "wired" feeling. This sense of sedation is often accompanied by uncontrollable yawning.
- Spontaneous physical sensations - The "body high" of 4-AcO-DET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. Unlike other 4-substituted tryptamines, 4-AcO-DET is capable of being more stimulating and anxiety-inducing.
- Appetite suppression
- Bodily pressures
- Excessive yawning
- Pupil dilation
- Runny nose
- Watery eyes
- Abnormal heartbeat
- Difficulty urinating or Frequent urination
- Watery eyes
- Increased bodily temperature
- Muscle contractions
- Restless leg syndrome
- Stomach bloating
- Stomach cramps
- Teeth grinding
Much like its hydroxylated counterpart 4-HO-DET, the cognitive effects of 4-AcO-DET are described by many as being relatively complex and unpredictable in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a notable number of typical and unique psychedelic cognitive effects. The most prominent of these typical effects generally include:
- Analysis enhancement
- Conceptual thinking
- Autonomous voice communication
- Déjà vu
- Emotion enhancement
- Enhancement and suppression cycles - This can be described as constant waves of extremely stimulated and profound thinking which are spontaneously surpassed in a cyclic fashion by waves of general thought suppression and mental intoxication. These two states seem to switch between each other in a consistent loop once every 20 - 60 minutes.
- Feelings of interdependent opposites
- Perception of predeterminism
- Immersion enhancement
- Increased music appreciation
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Thought connectivity
- Thought loops
- Time distortion
- Unity and interconnectedness
- Drifting (melting, breathing, morphing and flowing)
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
- After images
- Brightness alteration
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD, 2C-B or 2C-E than that of 4-AcO-DMT and ayahuasca. It can be comprehensively described through its variations as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. The visuals have a very "artificial" feel to them and at higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.
4-AcO-DET and its various other forms can produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Due to its relative obscurity, the possession and sale of 4-AcO-DET is unscheduled in most countries.
- 4-Acetoxy-DET - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/3-_2-_Diethylamino_ethyl_-1H-indol-4-yl_acetate#section=Top
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- "Sechste Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.
Data is constantly updated so please check back later to see if there is any more available information on this substance.