Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.
This is a commonly used substance with well known and widely available human consumption data. This does not guarantee that the substance will be safe. The safety profile has been established based on usage data commonly available.
Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.
Practice Harm Reduction. Proceed with Caution.
Also known as:
- 1H-Indol-4-ol, 3-[2
-(ethylmethylamino)[ACD/Index Name] ethyl]-
amino]ethyl}-1H-ind[ACD/IUPAC Name] ol-4-ol
amino]ethyl}-1H-ind[German][ACD/IUPAC Name] ol-4-ol
amino]éthyl}-1H-ind[French][ACD/IUPAC Name] ol-4-ol
- 3-2-ethyl(methyl) a
mine)ethyl)-1 H-ind[ACD/IUPAC Name] ole-4-ol
- 4-hydroxy MET
- MFCD09032995[MDL number]
A lesser known psychedelic tryptamine. Functional analogue of Psilocin. Very poorly soluble in water and alcohol.
4-HO-MET is chemically similar to Psilocin, the active ingredient in psilocybin mushrooms ("magic mushrooms"). Like other substituted tryptamines, it produces its psychedelic effects by acting on serotonin receptors in the brain. 4-HO-MET was first synthesized by Alexander Shulgin and reported in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved").
Reports of human use began to surface in the late 2000s following its appearance on the online research chemicals market. It has been sold alongside other psilocybin analogues such as 4-AcO-DMT and 4-HO-MiPT. User reports typically describe 4-HO-MET as a more recreational version of psilocybin mushrooms or psilocin (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects.
Notable effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocybin but there is no data to support this.
It is highly advised to use harm reduction practices if using this substance.
Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.
It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT).
It is also the 4-hydroxyl analog of the base tryptamine MET.
|Avg. Mass||218.2948 Da|
|Monoisotopic Mass||218.141907 Da|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Effects||A trip similar to mushrooms, hallucination and general shift in consciousness.|
|Marguis Test Result|
|Detection||Not known to be tested for in any standard drug tests|
4-HO-MET’s psychedelic effects are believed to come from its activity at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.
A large body of anecdotal reports suggests that the active dose can vary greatly. Some users report very heavy experiences with doses as low as 17mg, while others report light experiences with doses as high as 30 mg. Possible causes for this observed effect may be attributed to individual differences in neurochemistry and metabolism as well as large variations in the quality of different batches and physical forms (e.g. the HCl vs. fumarate salt) that it has appeared in.
- Stimulation - 4-HO-MET is primarily stimulating, although it can also be relaxing and stoning. This sets it apart from tryptamines like psilocybin and 4-AcO-DMT, which are primarily sedating.
- Spontaneous bodily sensations - The "body high" of 4-HO-MET can be described as a pleasurable, warm, soft, and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises following the onset and hits its limit once the peak has been reached.
- Changes in felt bodily form - This effect is often accompanied by a sense of warmth or unity and usually occurs around or directly after the peak of the experience. Users can feel as if they are physically part of or conjoined with other objects in a seamless continuity. This is usually reported as feeling comfortable, tranquil and mindful, although it can also manifest in the form of bodily tension
- Nausea - This effect can be greatly lessened or even completely avoided if the individual has an empty stomach prior to ingestion. It is sometimes recommended that one either refrain from eating for approximately 6 to 8 hours before-hand, or to eat a light meal 2 hours before if the user is feeling physically fatigued and undernourished. The nausea produced by 4-HO-MET is generally considered to be much less prominent than it is with psilocybin mushrooms, which has been attributed to the lack of fungal-matter the body has to digest when the isolated synthetic form is consumed.
- Temperature regulation suppression - 4-HO-MET can cause fluctuations in the user's internal sense of temperature, which can manifest as sudden bouts of uncomfortable coldness or warmth.
- Muscle contractions - The muscle contractions that can occasionally be produced by 4-HO-MET tend to be transient and benign feeling in nature, compared to many other tryptamines, phenethylamines and lysergamides.
- Increased heart rate
- Olfactory hallucination
- Pupil dilation
- Increased salivation
- Excessive yawning - This effect seems to be uniquely pronounced among psilocin and related tryptamines. It can occur to a lesser degree on LSD and very rarely on psychedelic phenethylamines like mescaline. It typically occurs in conjunction with watery eyes.
- Watery eyes
- Teeth grinding - This component is considerably less intense when compared with that of substances like MDMA when it does happen to occur, but happens more readily than with related substances like psilocin or psilocybin, perhaps owing to the greater degree of stimulation it produces.
- Brain zaps - Brain zaps are uncommon and thought to only occur in those who are susceptible to them. They are much less prevalent and intense than those that occur with serotonin releasing agents such as MDMA.
- Seizure - Psychedelics are known to lower the seizure threshold and may increase the likelihood of a seizure occurring in those who have a personal susceptibility or a family history of epilepsy. It is not considered a risk in healthy people.
The cognitive effects of 4-HO-MET are described by many as somewhat relaxing yet fast-paced in style with similarities to psychedelics such as LSD or 2C-B which tend to be cognitively energetic and stimulating.
- Analysis enhancement
- Conceptual thinking
- Autonomous voice communication
- Memory suppression
- Analysis enhancement - This effect is consistent in its manifestation and outrospection dominant.
- Novelty enhancement
- Immersion enhancement
- Creativity enhancement
- Increased music appreciation
- Increased sense of humor
- Novelty enhancement
- Personal bias suppression
- Thought acceleration
- Thought connectivity
- Thought loops
- Time distortion
4-HO-MET is commonly reported to produce visual effects with minimal accompanying cognitive effects or "head space" at lower doses.
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, cartoon-like in style, slow and smooth in motion and static in appearance.
- After images
- Colour shifting
- Scenery slicing
- Symmetrical texture repetition
The visual geometry produced by 4-HO-MET can be described as somewhat similar in appearance to that of psilocin (4-HO-DMT) and 4-HO-MiPT but with far stronger synthetic digital undertones reminiscent of LSD or 2C-B. 4-HO-MET can be comprehensively described through its variations as intricate in complexity, abstract in form, equally synthetic and organic in style, structured in organization, extremely brightly lit and multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of both LSD and psilocybin.
4-HO-MET and its various other forms produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high doses. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
Users report that transpersonal effects tend to occur less reliably and impactfully with 4-HO-MET than the closely related psilocin or psilocybin, and generally require heavier doses to induce. They are listed below as follows:
- Spirituality enhancement
- Existential self-realization
- Feelings of interdependent opposites
- Unity and interconnectedness
- Erowid. (2011). Erowid 4-HO-MET Vault. Retrieved from https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml
- Rickli A.; Moning O.D.; Hoener M.C.; Liechti M.E. "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens". :10.1016/j.euroneuro.2016.05.001. PMID 27216487.
- Täljemark J, Johansson BA. (2012). Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET. Eur Child Adolesc Psychiatry. 21(9), 527-8. doi:10.1007/s00787-012-0282-9
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
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- 1717 CheMall HE047221
- 1717 CheMall HE164889
- A&J Pharmtech AJ-80091
- ABI Chemicals AC2A030VP
- AKos AKOS015965048
- Amadis Chemical A15806
- American Custom Chemicals Corp CHM0149842
- Ark Pharm, Inc. AK-77118
- Aurora Fine Chemicals A06.997.512
- Aurora Fine Chemicals K05.595.151
- BGS International BG04535105
- Biosynth Carbosynth FH24440
- BOC Sciences 77872-41-4
- Boerchem BC219896
- Cayman Chemical 11148
- Cayman Chemical 11148.0
- Cayman Chemical CM245217
- Chembo Pharma KB-180148
- Chemenu CM245217
- ChemIDplus 77872414
- eMolecules 976887
- eNovation Chemicals D114060
- EPA DSSTox DTXCID90150982
- FDA UNII - NLM 6RN01B78NY
- Finetech Industry FT-0651533
- iChemical EBD210241
- Journal of Heterocyclic Chemistry 19810175_13A
- LabNetwork LN01303756
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- Wikidata Q2090804
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Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.
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