Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.
Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.
This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.
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4-HO-MET Also known as:
- 1H-Indol-4-ol, 3-[2
-(ethylmethylamino)[ACD/Index Name] ethyl]-
amino]ethyl}-1H-ind[ACD/IUPAC Name] ol-4-ol
amino]ethyl}-1H-ind[German][ACD/IUPAC Name] ol-4-ol
amino]éthyl}-1H-ind[French][ACD/IUPAC Name] ol-4-ol
- 3-2-ethyl(methyl) a
mine)ethyl)-1 H-ind[ACD/IUPAC Name] ole-4-ol
- 4-hydroxy MET
- MFCD09032995[MDL number]
A lesser known psychedelic tryptamine. Functional analogue of Psilocin. Very poorly soluble in water and alcohol.
4-HO-MET is chemically similar to Psilocin, the active ingredient in psilocybin mushrooms ("magic mushrooms"). Like other substituted tryptamines, it produces its psychedelic effects by acting on serotonin receptors in the brain. 4-HO-MET was first synthesized by Alexander Shulgin and reported in his 1997 book TiHKAL ("Tryptamines I Have Known and Loved").
Reports of human use began to surface in the late 2000s following its appearance on the online research chemicals market. It has been sold alongside other psilocybin analogues such as 4-AcO-DMT and 4-HO-MiPT. User reports typically describe 4-HO-MET as a more recreational version of psilocybin mushrooms or psilocin (4-HO-DMT) due to its less serious headspace and greater emphasis on visual effects.
Notable effects include geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. It is assumed to have a similar risk and toxicity profile as psilocybin but there is no data to support this.
It is highly advised to use harm reduction practices if using this substance.
Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
4-HO-MET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.
It also contains a methyl group and an ethyl chain bound to the terminal amine RN of its tryptamine backbone (MET). 4-HO-MET is a 4-hydroxy homolog of 4-AcO-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT).
It is also the 4-hydroxyl analog of the base tryptamine MET.
|Avg. Mass||218.2948 Da|
|Monoisotopic Mass||218.141907 Da|
- Erowid. (2011). Erowid 4-HO-MET Vault. Retrieved from https://erowid.org/chemicals/4_ho_met/4_ho_met.shtml
- Rickli A.; Moning O.D.; Hoener M.C.; Liechti M.E. "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens". :10.1016/j.euroneuro.2016.05.001. PMID 27216487.
- Täljemark J, Johansson BA. (2012). Drug-induced acute psychosis in an adolescent first-time user of 4-HO-MET. Eur Child Adolesc Psychiatry. 21(9), 527-8. doi:10.1007/s00787-012-0282-9
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
- 1717 CheMall HE047221
- 1717 CheMall HE164889
- A&J Pharmtech AJ-80091
- ABI Chemicals AC2A030VP
- AKos AKOS015965048
- Amadis Chemical A15806
- American Custom Chemicals Corp CHM0149842
- Ark Pharm, Inc. AK-77118
- Aurora Fine Chemicals A06.997.512
- Aurora Fine Chemicals K05.595.151
- BGS International BG04535105
- Biosynth Carbosynth FH24440
- BOC Sciences 77872-41-4
- Boerchem BC219896
- Cayman Chemical 11148
- Cayman Chemical 11148.0
- Cayman Chemical CM245217
- Chembo Pharma KB-180148
- Chemenu CM245217
- ChemIDplus 77872414
- eMolecules 976887
- eNovation Chemicals D114060
- EPA DSSTox DTXCID90150982
- FDA UNII - NLM 6RN01B78NY
- Finetech Industry FT-0651533
- iChemical EBD210241
- Journal of Heterocyclic Chemistry 19810175_13A
- LabNetwork LN01303756
- Mcule MCULE-4982794174
- MuseChem R055186
- MuseChem R055187
- NIST Spectra mainlib_379107
- Springer Nature A qualitative/quantitative approach for the detection of 37 tryptamine-derived designer drugs, 5 ??-carbolines, ibogaine, and yohimbine in human urine and plasma using standard urine screening and multi-analyte approaches
- VulcanChem VC259635
- VulcanChem VC259645
- Wikidata Q2090804
- Wikipedia 4-HO-MET
- Yuhao Chemical RT2128
Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.
Data is constantly updated so please check back later to see if there is any more available information on this substance.