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4-HO-DET Also known as:

  • 1H-Indol-4-ol, 3-[2-(diethylamino)ethyl]-[ACD/Index Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-[2-(Diéthylamino)éthyl]-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-Hydroxy-N,N-Diethyltryptamine(4-HO-DET)
  • '22204-89-3
  • 3-(2-(diethylamine) ethyl)-1 H-indole-4-ol[ACD/IUPAC Name]
  • 3-(2-(Diethylamino)ethyl)-1H-indol-4-ol
  • 3-(2-diethylaminoethyl)-1H-indol-4-ol
  • 3-(2-Diethylamino-ethyl)-1H-indol-4-ol
  • 3-(2-Diethylaminoethyl)indol-4-ol
  • 4-HO-DET
  • 4-hydroxy DET
  • 4-hydroxy DET|3-[2-(diethylamino)ethyl]-1H-indol-4-ol
  • 4-Hydroxy-diethyl-tryptamine
  • 4-Hydroxy-N,N-diethyltryptamine
  • CHEMBL143202
  • CZ 74
  • MFCD09033201[MDL number]
  • PDSP1_000021
  • PDSP2_000021

A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.


4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects. This compound was first discovered in the late 1950s by and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT).

The substance was used together with its phosphoryloxy-analog in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer. Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of psychedelic users preferring more traditional psychedelics like the psilocybin and psilocin in psilocybin mushrooms, or more recently, 4-AcO-DMT.

Today, it is either used as a recreational substance or an entheogen, has no documentation of being sold on the streets and is primarily acquired through the use of online research chemical vendors.


Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.

It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET). 4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET.

Std. InChiInChI=1S/C14H20N2O/c1-3-16(4-2)9-8-11-10-15-12-6-5-7-13(17)14(11)12/h5-7,10,15,17H,3-4,8-9H2,1-2H3
Avg. Mass232.3214 Da
Molecular Weight232.3214
Monoisotopic Mass232.157562 Da
Nominal Mass232
ChemSpider ID8167136

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Dose Chart


Duration Chart

4-HO-DET Duration Data
Onset30-60 minutes
Duration3-7 hours
After-effects1-12 hours

Legal Status



  1. Therapeutic indoles for psychic stimulation and relief of mental depression |
  2. United States Patent Office |
  3. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
  4. "Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
  5. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  6. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  7. Svensk författningssamling |
  8. Misuse of Drugs Act 1971 ( |

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.