4-HO-DET

4-HO-DET

4-HO-DET

Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

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Description

4-HO-DET

Also known as:

  • 1H-Indol-4-ol, 3-[2-(diethylamino)ethyl]-[ACD/Index Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-[2-(Diéthylamino)éthyl]-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-HYDROXY-N,N DIETHYLTRYPTAMINE
  • 4-Hydroxy-N,N-Diethyltryptamine(4-HO-DET)
  • '22204-89-3
  • 3-(2-(diethylamine) ethyl)-1 H-indole-4-ol[ACD/IUPAC Name]
  • 3-(2-(Diethylamino)ethyl)-1H-indol-4-ol
  • 3-(2-diethylaminoethyl)-1H-indol-4-ol
  • 3-(2-Diethylamino-ethyl)-1H-indol-4-ol
  • 3-(2-Diethylaminoethyl)indol-4-ol
  • 3-?[2-?(DIETHYLAMINO)ETHYL]-?1H-?INDOL-?4-?OL
  • 4-HO-DET
  • 4-hydroxy DET
  • 4-hydroxy DET|3-[2-(diethylamino)ethyl]-1H-indol-4-ol
  • 4-Hydroxy-diethyl-tryptamine
  • 4-HYDROXY-DIETHYL-TRYPTAMINE4-HYDROXY-DIETHYL-TRYPTAMINE
  • 4-Hydroxy-N,N-diethyltryptamine
  • CHEMBL143202
  • CZ 74
  • MFCD09033201[MDL number]
  • PDSP1_000021
  • PDSP2_000021

A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.

Summary

4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects. This compound was first discovered in the late 1950s by and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT).

The substance was used together with its phosphoryloxy-analog in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer. Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of psychedelic users preferring more traditional psychedelics like the psilocybin and psilocin in psilocybin mushrooms, or more recently, 4-AcO-DMT.

Today, it is either used as a recreational substance or an entheogen, has no documentation of being sold on the streets and is primarily acquired through the use of online research chemical vendors.

History

Chemistry

4-HO-DET

4-HO-DET

Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.

It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET). 4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET.

Common Name4-HYDROXY-N,N DIETHYLTRYPTAMINE
Systematic name4-HYDROXY-N,N DIETHYLTRYPTAMINE
FormulaC_{14}H_{20}N_{2}O
SMILESCCN(CC)CCc1c[nH]c2c1c(ccc2)O
Std. InChiInChI=1S/C14H20N2O/c1-3-16(4-2)9-8-11-10-15-12-6-5-7-13(17)14(11)12/h5-7,10,15,17H,3-4,8-9H2,1-2H3
Std. InChiKeyOHHYMKDBKJPILO-UHFFFAOYSA-N
Avg. Mass232.3214 Da
Molecular Weight232.3214
Monoisotopic Mass232.157562 Da
Nominal Mass232
ChemSpider ID8167136

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Dosing Guide

Oral
Light10-15mg
Common15-20mg
Strong20-30mg+

Duration

4-HO-DET Duration Data
Onset30-60 minutes
Duration3-7 hours
After-effects1-12 hours

Interactions and Synergies

There are no existing interaction or synergy data for this drug.

General Information

Experiences
Oral
Vaporization
Come up
Dosage
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
Avoid
Warning
Risks
Test Kits
Marguis Test Result
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

As with its structurally related tryptamines, 4-HO-DET principally acts as a 5-HT2A partial agonist, through which it exerts its psychedelic effects. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.

Subjective Effects

Physical Effects

Psychological Effects

The cognitive effects of 4-HO-DET can be described as mildly more stimulating and lucid in style when compared to other similar psychedelics such as psilocybin or 2C-C which tend to be more sedating. It has also been characterized as possessing a more "neutral", "analytical" headspace with minimal memory disruptions or emotional confusion compared to psilocybin mushrooms. The most prominent of these typical effects generally include:

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin, ayahuasca and 2C-T-7 than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, mostly synthetic in style, unstructured in organization, dimly lit and monotone in scheme, glossy in shading, sharp in edges, large in size, slow in speed, smooth in motion, equally rounded and angular in corners, non-immersive in-depth and consistent in intensity. They have a notably "synthetic" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status


References

  1. Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530
  2. United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf
  3. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
  4. "Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
  5. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  6. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  7. Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf
  8. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e

Sources

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.