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4-HO-DET Also known as:

  • 1H-Indol-4-ol, 3-[2-(diethylamino)ethyl]-[ACD/Index Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-[2-(Diethylamino)ethyl]-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-[2-(Diéthylamino)éthyl]-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-Hydroxy-N,N-Diethyltryptamine(4-HO-DET)
  • '22204-89-3
  • 3-(2-(diethylamine) ethyl)-1 H-indole-4-ol[ACD/IUPAC Name]
  • 3-(2-(Diethylamino)ethyl)-1H-indol-4-ol
  • 3-(2-diethylaminoethyl)-1H-indol-4-ol
  • 3-(2-Diethylamino-ethyl)-1H-indol-4-ol
  • 3-(2-Diethylaminoethyl)indol-4-ol
  • 4-HO-DET
  • 4-hydroxy DET
  • 4-hydroxy DET|3-[2-(diethylamino)ethyl]-1H-indol-4-ol
  • 4-Hydroxy-diethyl-tryptamine
  • 4-Hydroxy-N,N-diethyltryptamine
  • CHEMBL143202
  • CZ 74
  • MFCD09033201[MDL number]
  • PDSP1_000021
  • PDSP2_000021

A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.


4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects. This compound was first discovered in the late 1950s by and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT).

The substance was used together with its phosphoryloxy-analog in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer. Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of psychedelic users preferring more traditional psychedelics like the psilocybin and psilocin in psilocybin mushrooms, or more recently, 4-AcO-DMT.

Today, it is either used as a recreational substance or an entheogen, has no documentation of being sold on the streets and is primarily acquired through the use of online research chemical vendors.




Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.

It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET). 4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET.

Std. InChiInChI=1S/C14H20N2O/c1-3-16(4-2)9-8-11-10-15-12-6-5-7-13(17)14(11)12/h5-7,10,15,17H,3-4,8-9H2,1-2H3
Avg. Mass232.3214 Da
Molecular Weight232.3214
Monoisotopic Mass232.157562 Da
Nominal Mass232
ChemSpider ID8167136

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Dose Chart


Duration Chart

4-HO-DET Duration Data
Onset30-60 minutes
Duration3-7 hours
After-effects1-12 hours

Auditory Effects

Psychological Effects

The cognitive effects of 4-HO-DET can be described as mildly more stimulating and lucid in style when compared to other similar psychedelics such as psilocybin or 2C-C which tend to be more sedating. It has also been characterized as possessing a more "neutral", "analytical" headspace with minimal memory disruptions or emotional confusion compared to psilocybin mushrooms. The most prominent of these typical effects generally include:

Pharmacological Effects

As with its structurally related tryptamines, 4-HO-DET principally acts as a 5-HT2A partial agonist, through which it exerts its psychedelic effects. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.

Physical Effects

Subjective Effects

Visual Effects




The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin, ayahuasca and 2C-T-7 than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, mostly synthetic in style, unstructured in organization, dimly lit and monotone in scheme, glossy in shading, sharp in edges, large in size, slow in speed, smooth in motion, equally rounded and angular in corners, non-immersive in-depth and consistent in intensity. They have a notably "synthetic" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

Legal Status



  1. Therapeutic indoles for psychic stimulation and relief of mental depression |
  2. United States Patent Office |
  3. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
  4. "Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
  5. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  6. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  7. Svensk författningssamling |
  8. Misuse of Drugs Act 1971 ( |

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.