Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
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Also known as:
- 1H-Indol-4-ol, 3-[2
-(diethylamino)ethy[ACD/Index Name] l]-
- 4-HYDROXY-N,N DIETH
ethyl)-1 H-indole-[ACD/IUPAC Name] 4-ol
- 4-hydroxy DET
- 4-hydroxy DET|3-[2-
- CZ 74
- MFCD09033201[MDL number]
A rare compound first produced by Albert Hoffman, also known as ethocin. Structurally related to 4-HO-MET (metocin) and psilocin (4-HO-DMT), this drug has similar psychedelic effects but little recorded human usage. Probably similar to mushrooms. Potentially stimulating.
4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects. This compound was first discovered in the late 1950s by and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT).
The substance was used together with its phosphoryloxy-analog in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer. Since its inception, 4-HO-DET has remained relatively uncommon and has very little documentation of human usage, with the majority of psychedelic users preferring more traditional psychedelics like the psilocybin and psilocin in psilocybin mushrooms, or more recently, 4-AcO-DMT.
Today, it is either used as a recreational substance or an entheogen, has no documentation of being sold on the streets and is primarily acquired through the use of online research chemical vendors.
Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
4-HO-DET is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−.
It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET). 4-HO-DET is the lower homolog of 4-AcO-DET, the N-substituted diethyl homolog of 4-HO-DMT (psilocin) and the 4-hydroxy analog of DET.
|Common Name||4-HYDROXY-N,N DIETHYLTRYPTAMINE|
|Systematic name||4-HYDROXY-N,N DIETHYLTRYPTAMIN|
|Avg. Mass||232.3214 Da|
|Monoisotopic Mass||232.157562 Da|
|4-HO-DET Duration Data|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Effects||Euphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.|
|Marguis Test Result|
As with its structurally related tryptamines, 4-HO-DET principally acts as a 5-HT2A partial agonist, through which it exerts its psychedelic effects. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.
- Spontaneous physical sensations
- Tactile enhancement
- Temperature regulation suppression
- Bodily control enhancement
- Increased heart rate
- Excessive yawning - This effect seems to be uniquely pronounced among psilocin and related tryptamines. It can occur to a lesser degree on LSD and very rarely on psychedelic phenethylamines like mescaline. It typically occurs in combination with watery eyes. However, many anecdotal reports suggest that this component is not as noticeable compared to the aforementioned psychedelics
- Watery eyes
- Frequent urination
- Muscle contractions
- Olfactory hallucination
- Pupil dilation
- Runny nose
The cognitive effects of 4-HO-DET can be described as mildly more stimulating and lucid in style when compared to other similar psychedelics such as psilocybin or 2C-C which tend to be more sedating. It has also been characterized as possessing a more "neutral", "analytical" headspace with minimal memory disruptions or emotional confusion compared to psilocybin mushrooms. The most prominent of these typical effects generally include:
- Analysis enhancement
- Conceptual thinking
- Immersion enhancement
- Increased music appreciation
- Increased sense of humor
- Memory suppression
- Novelty enhancement
- Personal bias suppression
- Thought acceleration
- Thought connectivity
- Thought loops
- Time distortion
- Drifting (melting, breathing, morphing and flowing)
- Colour tinting
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin, ayahuasca and 2C-T-7 than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, mostly synthetic in style, unstructured in organization, dimly lit and monotone in scheme, glossy in shading, sharp in edges, large in size, slow in speed, smooth in motion, equally rounded and angular in corners, non-immersive in-depth and consistent in intensity. They have a notably "synthetic" feel to them and at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
- Therapeutic indoles for psychic stimulation and relief of mental depression | http://www.google.com/patents/US3072530
- United States Patent Office | https://www.erowid.org/archive/rhodium/pdf/psilocin.esters.pdf
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- "Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Svensk författningssamling | http://www.notisum.se/rnp/sls/sfs/20050733.pdf
- Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e
- 1717 CheMall HE050096
- 1717 CheMall HE165737
- ABI Chemicals AC2A00S61
- AK Scientific W4581
- AKos AKOS015967170
- Alichem A490021784
- American Custom Chemicals Corp AAA0009520
- Anward ANW-46066
- Ark Pharm, Inc. AK-77119
- Aurora Fine Chemicals A06.998.029
- Aurora Fine Chemicals K05.595.141
- BePharm 3-(2-(Diethylamino)ethyl)-1H-indol-4-ol
- BindingDB 50094675
- Biosynth Carbosynth FH24432
- BOC Sciences 22204-89-3
- Boerchem BC220656
- Cayman Chemical 14294
- Cayman Chemical 14294.0
- ChEMBL CHEMBL143202
- ChemIDplus 22204893
- Chemspace CSC016987265
- eMolecules 976865
- eNovation Chemicals K49528
- EPA DSSTox DTXCID9099246
- FDA UNII - NLM 7E0BR15575
- FDA UNII - NLM UNII: 7E0BR15575
- Finetech Industry FT-0669543
- GuiChem GZ013598
- iChemical EBD3042094
- Journal of Heterocyclic Chemistry 19770071_4A
- LabNetwork LN01286754
- Letopharm LT0317633
- Mcule MCULE-5738037747
- Molport MolPort-001-784-340
- MuseChem R055208
- MuseChem R055210
- PubChem 9991554
- Sayibo Inc W53746
- Thomson Pharma 00513233
- Tractus Company Limited
- VulcanChem VC259825
- VulcanChem VC259843
- Wikidata Q4637139
- Wikipedia 4-HO-DET
Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.
Data is constantly updated so please check back later to see if there is any more available information on this substance.