4-AcO-MiPT

4-AcO-MiPT

4-AcO-MiPT

Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

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Description

4-AcO-MiPT

Also known as:

  • 1H-Indol-4-ol, 3-[2-[methyl(1-methylethyl)amino]ethyl]-, acetate (ester)[ACD/Index Name]
  • 3-{2-[Isopropyl(methyl)amino]ethyl}-1H-indol-4-yl acetate[ACD/IUPAC Name]
  • 3-{2-[Isopropyl(methyl)amino]ethyl}-1H-indol-4-yl-acetat[German][ACD/IUPAC Name]
  • Acétate de 3-{2-[isopropyl(méthyl)amino]éthyl}-1H-indol-4-yle[French][ACD/IUPAC Name]
  • MIPRACETIN
  • SS93IMV779
  • [3-[2-[Isopropyl(methyl)amine]ethyl]-1H-indol-4-yl] acetate[ACD/IUPAC Name]
  • [3-[2-[methyl(propan-2-yl)amino]ethyl]-1H-indol-4-yl] acetate
  • 3-(2-(Isopropyl(methyl)amino)ethyl)-1H-indol-4-yl acetate
  • 3-{2-[Methyl(propan-2-yl)amino]ethyl}-1H-indol-4-yl acetate
  • 4-Acetate 3-[2-[methyl(1-methylethyl)amino]ethyl]-1H-indol-4-ol
  • 4-Acetoxy-N,N-Methylisopropyltryptamine
  • 4-Acetoxy-N-isopropyl-N-methyltryptamine
  • 4-ACETOXY-N-ISOPROPYL-N-METHYLTRYPTAMINE-D4
  • 4-AcOMIPT
  • 4-AcO-N,N-MIPT
  • MFCD16293750[MDL number]
  • UNII:SS93IMV779

A quite potent tryptamine that has be related to having “shroom-like” visuals. Yet without much bodyload. Very hydroscopic. Seems to be quite safe in dosing. Similar to the likes of 2C-B.

Summary

It is the acetylated form of 4-HO-MiPT (also known as miprocin) and is a higher homolog of 4-AcO-DMT, 4-AcO-MET and 4-AcO-DET. These substances are commonly hypothesized to act primarily as prodrugs for their respective hydroxylated counterparts (e. g.

4-HO-DMT, 4-HO-MET and 4-HO-DET), although there is on-going debate as to whether they possess their own innate activity. There is very little information on the human pharmacology or toxicity of 4-AcO-MiPT, although analytical methods have been developed for its detection. Today it is either used recreationally or as an entheogenic substance and is typically acquired through the use of online research chemical vendors.

It remains relatively uncommon and has very little history of human usage.

History

Chemistry

4-AcO-MiPT

4-AcO-MiPT

Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-AcO-MiPT is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−.

It also contains isopropyl and methyl chains bound to the terminal amine RN of its tryptamine backbone (MiPT). 4-AcO-MiPT is the N-substituted methisopropyl homologue of 4-HO-DMT (psilocin).

4-AcO-MiPT is the acetate ester analog of MiPT and the N-substituted methisopropyl analog of 4-AcO-DMT.

Common NameMIPRACETIN
Systematic nameMIPRACETIN
FormulaC_{16}H_{22}N_{2}O_{2}
SMILESCC(C)N(C)CCc1c[nH]c2c1c(ccc2)OC(=O)C
Std. InChiInChI=1S/C16H22N2O2/c1-11(2)18(4)9-8-13-10-17-14-6-5-7-15(16(13)14)20-12(3)19/h5-7,10-11,17H,8-9H2,1-4H3
Std. InChiKeyCIDMXLOVFPIHDS-UHFFFAOYSA-N
Avg. Mass274.3581 Da
Molecular Weight274.3581
Monoisotopic Mass274.168121 Da
Nominal Mass274
ChemSpider ID23976075

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Dosing Guide

Oral
Light5-10mg
Common10-20mg
Strong20-40mg.
Vapourized
Light2-5mg
Common5-10mg
Strong10-15

Duration

Oral
Onset15-45 minutes
Duration4-9 hours

Interactions and Synergies

There are no existing interaction or synergy data for this drug.

General Information

Experiences
Oral
Vaporization
Come up
Dosage
Effects
After Effects
Avoid
Warning
Risks
Test Kits
Marguis Test Result
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

Like with most psychedelic tryptamines, 4-AcO-MiPT is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-AcO-MiPT’s binding efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical Effects

  • Excessive yawning
  • Sedation - In terms of its effects on the physical energy levels of the tripper, 4-AcO-MiPT is considered by most to be relaxing, stoning and mildly sedating. This sense of sedation is often accompanied by uncontrollable yawning.
  • Spontaneous tactile sensations - The "body high" of 4-AcO-MiPT can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
  • Pupil dilation
  • Runny nose
  • Watery eyes

Psychological Effects

Much like its counterpart 4-HO-MiPT, the cognitive effects of 4-AcO-MiPT are described by many as extremely relaxing, complex and stoning in style when compared to other commonly used psychedelics such as LSD or 2C-B which tend to be energetic and stimulating. It contains a notable number of typical and unique psychedelic cognitive effects. The most prominent of these typical effects generally include:

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry of this compound can be described as more similar in appearance to that of 4-AcO-DMT, ayahuasca and 2C-T-7 than LSD or 2C-B. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, soft in edges, large in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. The visuals have a very "natural" feel to them and at higher dosages are significantly more likely to result in states of level 8B visual geometry over level 8A.

Hallucinatory states

4-AcO-MiPT and its various other forms can produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. These effects generally include:

Auditory Effects

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal Effects

It should be noted that these effects are reported to occur less reliably and impactfully than with psilocybin or 4-AcO-DMT, and generally require heavier doses to induce.

Legal Status

Due to its relative obscurity, the possession and sale of 4-AcO-MiPT is unscheduled in most countries.

  • Germany: 4-AcO-MiPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Sweden: 4-AcO-MiPT is classified as "health hazard" under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated to the "Act on the Prohibition of Certain Goods Dangerous to Health"). The drug is listed in their regulation SFS 2005:733, making it illegal to sell or possess.
  • United Kingdom: 4-AcO-MiPT is a Class A drug in the UK as it is an ester of the drug 4-HO-MiPT., which is a Class A drug as a result of the tryptamine catch-all clause.
  • United States: 4-AcO-MiPT is unscheduled in the United States. It may be considered an analogue of psilocin (4-HO-DMT) which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.

  • References

    1. http://www.sciencedirect.com/science/article/pii/S0039914008005808
    2. http://link.springer.com/article/10.1007/s00044-011-9794-y
    3. 4-Acetoxy-MiPT - PubChem | https://pubchem.ncbi.nlm.nih.gov/compound/467835878
    4. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    5. "Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    6. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    7. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    8. http://www.notisum.se/rnp/sls/sfs/20050733.pdf
    9. Misuse of Drugs Act 1971 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I/paragraph/3
    10. Misuse of Drugs Act 1971 (Legislation.gov.uk) |http://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/I#reference-M_F_c7632653-ddad-4420-f307-e3da1e36d30e

    Sources

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.