Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

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2C-I Also known as:

  • 2-(4-Iod-2,5-dimethoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Iodo-2,5-dimethoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Iodo-2,5-diméthoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 2C-I
  • 4-iodo-2,5-dimethoxy-β-phenethylamine
  • Benzeneethanamine, 4-iodo-2,5-dimethoxy-[ACD/Index Name]
  • 2-(4-iodo-2,5-dimethoxy-phenyl)ethanamine
  • 2-(4-iodo-2,5-dimethoxy-phenyl)ethylamine
  • 2-(4-Iodo-2,5-dimethoxy-phenyl)-ethylamine
  • 2,5-Dimethoxy-4-iodo phenethylamine
  • 2-[4-(125i)iodo-2,5-dimethoxyphenyl]ethanamine
  • 2C-I[Japanese]
  • 4-Iodo-2,5-dimethoxyphenethylamine HCI
  • 4-Iodo-2,5-dimethoxy-phenylethylamine hydrochloride
  • '69587-11-7
  • phenethylamine, 2,5-dimethoxy-4-iodo-

A psychedelic similar to the more well-known 2C-B. Users frequently report very vivid and bright open-eye visuals and more mild closed-eye visuals compared to 2C-B and other drugs in the 2C family. Can also be more stimulating than 2C-B along with having a slight body load for some users. Less safe at high doses compared to 2C-B


It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. 2C-I was first synthesized and investigated for human activity by Alexander Shulgin in 1976 and later described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). Its PiHKAL entry notes it for being "very colorful and active" but without "feelings of insight, revelation, or progress toward the true meaning of the universe.

" It first briefly gained some popularity in the late 1990s and early 2000s, where it was sold in several smart shops as a replacement for 2C-B following its scheduling in 1995. It also has a history of being sold online as a research chemical before becoming scheduled. 2C-I is typically used recreationally for its psychedelic as well as moderate stimulating and entactogenic effects.

It has been explored as a potential stimulant nootropic in the 1-8mg dosage range. Little data exists about the pharmacological properties, metabolism, and toxicity of 2C-I, and it has a limited history of human use. 2C-I is sometimes confused for the analog 25I-NBOMe (an abbreviated form of 2C-I-NBOMe).

It is highly advised to use harm reduction practices if using this substance.


2C-I contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as an iodine atom attached to carbon R4 of the phenyl ring.

2C-I belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Std. InChiInChI=1S/C10H14INO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3
Avg. Mass307.1281 Da
Molecular Weight307.1281
Monoisotopic Mass307.006927 Da
Nominal Mass307
ChemSpider ID8442670

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Dose Chart


Duration Chart

Onset45-120 minutes
Duration4-12 hours
After-effects4-12 hours



  1. Mescaline
  2. DOx
  3. NBOMes
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  8. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  9. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.

Low Synergy

  1. Alcohol
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
  5. MXE
  6. DXM
  7. PCP
  8. N2O
  9. MDMA

Legal Status

  • Austria: 2C-I is illegal to possess, produce and sell under the SMG. (Suchtmittelgesetz Österreich)
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-I is a schedule III controlled substance in Canada.
  • Denmark: 2C-I is a controlled substance in Denmark.
  • European Union: In December 2003, the European Council issued a binding order compelling all EU member states to ban 2C-I within three months.
  • Germany: 2C-I is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of October 10, 1999. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Greece: 2C-I is a controlled substance in Greece.
  • Ireland: 2C-I is a controlled substance in Ireland.
  • Italy: 2C-I is a controlled substance in Italy.
  • Latvia: 2C-I is a Schedule I controlled substance Latvia.
  • The Netherlands: 2C-I is a controlled substance in the Netherlands.
  • Poland: 2C-I is a controlled substance in Poland.
  • Sweden: Sveriges riksdag added 2C-I to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as a narcotic in Sweden as of March 16, 2004.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: 2C-I is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: As of July 9, 2012, 2C-I is a Schedule I substance in the U.S. under the Synthetic Drug Abuse Prevention Act of 2012, making possession, distribution and manufacture illegal.
  • Sources


    1. Alexander Shulgin - PiHKAL |
    2. Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p179 ( |
    3. Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "PiHKAL" - #33 - 2C-I. Retrieved Jan 22, 2018.
    6. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
    8. Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)
    9., Legal Status of 2C-I
    10. "Dreizehnte Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    11. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    12. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    13. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) |
    16. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from


    1. ABI Chemicals AC1Q4FDC
    2. AEchem Scientific AE1-003775
    3. AKos AKOS015891190
    4. Alfa Chemistry 69587-11-7
    5. American Custom Chemicals Corp HCH0017894
    6. Atomole Scientific AT-23840
    7. Aurora Fine Chemicals K13.730.441
    8. Biosynth Carbosynth FI12173
    9. ChEMBL CHEMBL338297
    10. Chembo Pharma KB-192844
    11. ChemIDplus 69587117
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