Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.
Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.
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2C-I Also known as:
hoxyphenyl)ethanami[ACD/IUPAC Name] ne
hoxyphényl)éthanami[French][ACD/IUPAC Name] ne
4-iodo-2,5-dimethox[ACD/Index Name] y-
- phenethylamine, 2,5
A psychedelic similar to the more well-known 2C-B. Users frequently report very vivid and bright open-eye visuals and more mild closed-eye visuals compared to 2C-B and other drugs in the 2C family. Can also be more stimulating than 2C-B along with having a slight body load for some users. Less safe at high doses compared to 2C-B
It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. 2C-I was first synthesized and investigated for human activity by Alexander Shulgin in 1976 and later described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). Its PiHKAL entry notes it for being "very colorful and active" but without "feelings of insight, revelation, or progress toward the true meaning of the universe.
" It first briefly gained some popularity in the late 1990s and early 2000s, where it was sold in several smart shops as a replacement for 2C-B following its scheduling in 1995. It also has a history of being sold online as a research chemical before becoming scheduled. 2C-I is typically used recreationally for its psychedelic as well as moderate stimulating and entactogenic effects.
It has been explored as a potential stimulant nootropic in the 1-8mg dosage range. Little data exists about the pharmacological properties, metabolism, and toxicity of 2C-I, and it has a limited history of human use. 2C-I is sometimes confused for the analog 25I-NBOMe (an abbreviated form of 2C-I-NBOMe).
It is highly advised to use harm reduction practices if using this substance.
2C-I contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as an iodine atom attached to carbon R4 of the phenyl ring.
2C-I belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.
|Avg. Mass||307.1281 Da|
|Monoisotopic Mass||307.006927 Da|
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- The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
- Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
- The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
- MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
- High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
- Alexander Shulgin - PiHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal033.shtml
- Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p179 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook1_searchable.pdf
- Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "PiHKAL" - #33 - 2C-I. Retrieved Jan 22, 2018.
- Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
- Regulations Amending the Food and Drug Regulations (Part J — 2C-phenethylamines)
- Erowid.org, Legal Status of 2C-I
- "Dreizehnte Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
- United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
- ABI Chemicals AC1Q4FDC
- AEchem Scientific AE1-003775
- AKos AKOS015891190
- Alfa Chemistry 69587-11-7
- American Custom Chemicals Corp HCH0017894
- Atomole Scientific AT-23840
- Aurora Fine Chemicals K13.730.441
- Biosynth Carbosynth FI12173
- ChEMBL CHEMBL338297
- Chembo Pharma KB-192844
- ChemIDplus 69587117
- eMolecules 977204
- FDA UNII - NLM S35362848V
- iChemical EBD1149345
- Jalor-Chem I01-9077
- LabNetwork LN01285796
- Laboratory Chemical Safety Summary 10267191
- Manchester Organics L45551
- MuseChem R068071
- NIST Spectra mainlib_335036
- Paragos 310081
- Parchem – fine & specialty chemicals 112355
- PubChem 10267191
- PubMed 16325192
- PubMed 17223101
- PubMed 592317
- Sayibo Inc W47924
- Shanghai IS Chemical Technology I01-9077
- SORD SST0025413
- SORD SST0025413
- Springer Nature 2-(4-Iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe): Clinical Case with Unique Confirmatory Testing
- Springer Nature A model system for prediction of the in vivo metabolism of designer drugs using three-dimensional culture of rat and human hepatocytes
- Springer Nature Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review
- Springer Nature Cross-reactivities of 39 new amphetamine designer drugs on three abuse drugs urinary screening tests
- Springer Nature Cross-reactivities of 41 new amphetamine designer drugs to EMIT?? immunoassays
- Springer Nature Hallucinogen Dependence
- Springer Nature Simultaneous analysis of six phenethylamine-type designer drugs by TLC, LC-MS, and GC-MS
- Thomson Pharma 00586604
- VulcanChem VC329107
- Wikidata Q209255
- Wikipedia 2C-I
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- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.
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