Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.
Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.
Practice Harm Reduction. Proceed with Caution.
Also known as:
etrahydrofuro[2,3-f[German][ACD/IUPAC Name] ]benzofuran-4-yl )ethanamin
tetrahydrobenzo[1,2 -b:4,5-b']difuran-4 -yl)ethanamine
tetrahydrofuro[2,3-[ACD/IUPAC Name] f]benzofuran-4-y l)ethanamine
tétrahydrofuro[2,3-[French][ACD/IUPAC Name] f]benzofuran-4-y l)éthanamine
RAHYDROBENZO(1,2-B: 4,5-B')DIFURAN-4-ET HANAMINE
difuran-4-ethanamin[ACD/Index Name] e, 8-bromo-2,3,6,7- tetrahydro-
tetrahydrofuro[2,3- f]benzofuran-8-yl)e thanamine
tetrahydrobenzo[1,2 -b:4,5-b]difuran-4- yl)ethanamine
tetrahydrobenzo-[1, 2-b:4,5-b']difuran- 4-yl)ethanamine
tetrahydrobenzo[1,2 -b:4,5-b`]difuran-4 -yl)ethanamine
tetrahydro-benzo[1, 2-b;4,5-b']difuran- 4-yl)-ethylamine
tetrahydrobenzofuro [5,6-b]furan-4-yl)e thanamine hydrochlo ride
tetrahydrofuro[2,3-[ACD/IUPAC Name] f]benzofurane-4- yl)ethanamine
zo-dihydro-difurane[ACD/IUPAC Name] -ethylamine
Psychedelic phenethylamine that is the dihydrodifuran analog of 2C-B.
Reports have characterized its effects profile as possessing features of 2C-B, mescaline and MDA, with a duration of 6–8 hours (or up to 12 hours in larger doses). 2C-B-FLY is a derivative of the 2C-x family of psychedelic phenethylamines, specifically 2C-B, of which it significantly differs from in terms of its potency, metabolism, and potential toxicity. It was first synthesized by Aaron P.
Monte in 1996. Around 2005, 2C-B-FLY appeared and gained some popularity in the online research chemicals market before largely disappearing in October 2009, when a batch of Bromo-DragonFLY was accidentally mislabeled as 2C-B-FLY (Bromo-DragonFLY is dosed in micrograms, where 2C-B-FLY is dosed in milligrams) led to two deaths as a result of taking overdoses of Bromo-DragonFLY meant to be effective doses for 2C-B-FLY. This event led to its immediate withdrawal until around 2016, when it resurfaced on the market again.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY, and it has little history of human usage. It has no documented history of being sold on the streets and is commercially distributed through online research chemical vendors. Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for 2C-B.
It is highly advised to approach this potent, long-lasting, and unpredictable hallucinogenic substance with the proper amount of precaution and harm reduction practices if choosing to use it.
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In a 2007 MAPS newsletter interview, Ann Shulgin revealed that 2C-B-FLY as one of her favorite psychedelic substances while also acknowledging the high variability in responses it seemed to display.
I said often, too often, that something called 2CB Fly (sic) was absolutely great for me. To me, it’s the loveliest thing, especially for eroticism. But I found out that it’s not interesting to anybody else.— Ann Shulgin
I realized that having said that, I was putting things in motion. The Internet was full of 2CB Fly (sic), and people were asking about it and I thought “uh-oh.” It turned out that it’s a disappointment to most other people.
2C-B-FLY features a phenyl ring bound to an amino (NH2) group through an ethyl chain and contains a bromine atom attached to carbon R4 of the phenyl ring. It is an atypical psychedelic phenethylamine which is closely analogous to 2C-B; it is the dihydrofuran analog to 2C-B, where it incorporates the methoxy groups bound to R2 and R5 of 2C-B into five-member dihydrofuran rings fused to the central benzene ring. 2C-B-FLY belongs to a group of phenethylamine derivatives referred to as the FLY compounds, named for their insect-like appearance of two “wing-like” tetrahydrofuran rings fused on the opposite sides of the central benzene ring.
The incorporation of the two methoxy groups into the 5 member rings fixes them into the optimum position for binding to the receptors they interact with resulting in an increase in potency compared to the compound’s non-rigid counterpart 2C-B.
|Avg. Mass||284.1491 Da|
|Monoisotopic Mass||283.020782 Da|
|2C-B-FLY Duration Data|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Effects||Euphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.|
|Marguis Test Result|
Little is known about how the totality of its effects are produced, 2C-B-FLY’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.
In comparison to 2C-B, this compound presents a significantly more pronounced body high/load, stronger visual effects, more complex geometry and more in-depth internal hallucinations which are comparable to mescaline, 2C-E or MDA at higher doses. Lower doses, however, are associated with more entactogenic as opposed to classical psychedelic effects.
The physical effects of 2C-B-FLY are comparable to that of traditional phenethylamines such as 2C-E, mescaline and 2C-T-7 along with more pronounced side effects. There have been reports gastrointestinal disturbances following the use of this compound which include diarrhea, nausea, moderate to severe stomach bloating and general gassiness at moderate to heavy doses. These effects are comparable to that of 5-MeO-MiPT, 2C-T-7 and other compounds with suspected MAO-altering properties. This suggests that 2C-B-FLY may potentially have such MAO-altering properties of its own, which may make it dangerous to combine with certain substances.
- Stimulation and Sedation - At light dosages, this compound is generally stimulating but in a gentle, non-forceful manner similar to that of 2C-B or mescaline. At higher dosages one may find the amount of stimulation to increase to an uncomfortable level with undertones of sedation or lethargy in a manner similar to that of 2C-C or 2C-T-7.
- Spontaneous physical sensations - The "body high" of 2C-B-FLY can be described as a pleasurable, warm, soft, all-encompassing and mild tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. It is comparable to that of a milder mescaline, 2C-B or 2C-E experience.
- Tactile enhancement
- Temperature regulation suppression - Compared to 2C-B, this effect is far more pronounced and unpredictable in its manifestation. Small increases in the dose may result in large changes in this effect.
- Bodily control enhancement
- Bodily pressures
- Increased blood pressure
- Increased libido
- Headaches - This effect is more commonly reported than 2C-B or other traditional phenethylamines.
- Muscle cramps
- Stomach bloating
- Stomach cramps
- Excessive yawning
- Watery eyes
- Pupil dilation
- Teeth grinding
2C-B-FLY tends to maintain a level of relatively normal and sober thought structure regardless of the subjective visual, physical and cognitive accompanying effects intensity. This leaves the user in control in a manner which would not be possible on many compounds such as 4-AcO-DMT or LSD due to their accompanying confusion and delusions.
- Conceptual thinking
- Creativity enhancement
- Emotion enhancement
- Empathy, affection, and sociability enhancement - This compound presents entactogenic effects on a level which is less intense than that of 2C-B or MDMA but similar in quality to that of mescaline or 2C-E.
- Increased libido
- Increased music appreciation
- Increased sense of humor
- Memory suppression
- Novelty enhancement
- Thought acceleration
- Time distortion
- Drifting (melting, breathing, morphing and flowing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, intricate in appearance and unrealistic/cartoon-like in style. It is very comparable to that of 2C-B or mescaline.
- After images
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of mescaline, 2C-B and 2C-D than psilocin or ayahuasca. It can be comprehensively described through its style variations as intricate in complexity, abstract in form, synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, flat in edges, large in size, fast in speed, smooth in motion, angular in corners, non-immersive in-depth and consistent in intensity. They have a contradictory combination of a very "natural" but also "neon digital" feel to them and at higher dosages are significantly more likely to result in states of level 8B visual geometry over level 8A.
2C-B-FLY produces a moderate range of hallucinatory states in a fashion that is comparable to mescaline or common doses of 2C-E. This is more consistent and reproducible than that of many other commonly used psychedelics such as 2C-B or LSD. It tends to occur at heavier dosages and integrates seamlessly with the accompanying geometry. These effects generally include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)
- Information on Reported Deaths Related to 2C-B-FLY | https://www.erowid.org/chemicals/2cb_fly/2cb_fly_death1.shtml
- Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089. 1556-9039.
- Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
- "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
- "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
- "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
- Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
- Abblis Chemicals AB1006818
- AKos AKOS015950994
- Alichem A019106609
- Amadis Chemical A812382
- Angene AGN-PC-0QBDK6
- Ark Pharm, Inc. AK327320
- Aurora Fine Chemicals A24.548.152
- Aurora Fine Chemicals K18.962.873
- BGS International BG00992990
- BindingDB 50052339
- BLDpharm BD18943
- ChEMBL CHEMBL101189
- ChemIDplus 178557216
- ChemIDplus 733720951
- ChemShuttle 131866
- Chemspace CSC015193111
- EPA DSSTox DTXCID0093001
- Erowid 2C-B-Fly
- FDA UNII - NLM Z1T18Z40OT
- LabNetwork LN02189463
- Laboratory Chemical Safety Summary 10265873
- Mcule MCULE-8907136377
- MuseChem R052417
- PubChem 10265873
- SORD SST0025433
- SORD SST0025433
- Thomson Pharma 00536910
- VulcanChem VC245489
- Wikidata Q4633042
- Wikipedia 2C-B-FLY
Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.
Data is constantly updated so please check back later to see if there is any more available information on this substance.