2C-B

2C-B

2C-B

Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

This is a commonly used substance with well known and widely available human consumption data. This does not guarantee that the substance will be safe. The safety profile has been established based on usage data commonly available.

Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Practice Harm Reduction. Proceed with Caution.

Description

2C-B

Also known as:

  • 2-(4-Brom-2,5-dimethoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Bromo-2,5-dimethoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Bromo-2,5-diméthoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine
  • 2C-B
  • 4-Bromo-2,5-dimethoxybenzeneethanamine
  • 4-Bromo-2,5-dimethoxyphenethylamine
  • a-Desmethyl DOB
  • Benzeneethanamine, 4-bromo-2,5-dimethoxy-[ACD/Index Name]
  • MFT
  • Nexus
  • phenethylamine, 4-bromo-2,5-dimethoxy-
  • V77772N32H
  • (±) 1-(4-BROMO-2 5-DIMETHOXYPHENYL)-2
  • (±) 1-(4-BROMO-2 5-DIMETHOXYPHENYL)-2&
  • 1-(4-bromo-2,5-dimethoxyphenyl)-2-ethanamine
  • 2-(4-bromo-2,5-dimethoxyphenyl)ethan-1-amine
  • 2-(4-bromo-2,5-dimethoxy-phenyl)ethanamine
  • 2-(4-bromo-2,5-dimethoxy-phenyl)ethylamine
  • 2-(4-Bromo-2,5-dimethoxy-phenyl)-ethylamine
  • 2,5-dimethoxy-4-bromophenethylamine
  • 2-CB
  • 4863873
  • 4-BROM-2,5-DIMETHOXYPHENYLETHYLAMINE
  • 4-Bromo-2,5-dimethoxyphenylethylamine
  • BDMPEA
  • Nexus (pharmaceutical)
  • PDSP1_001367
  • PDSP2_001351
  • UNII:V77772N32H
  • UNII-V77772N32H

A popular psychedelic in the phenethylamine family. Provides empathic experiences at lower doses and strong visual and psychedelic experiences at higher doses. Commonly used as a party drug as it is more clear-headed than most psychedelics. 2C-B has been in use since the early 1990s

Summary

2C-B is the most popular member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. It is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. 2C-B was first discovered in 1974 by the American chemist Alexander Shulgin, who would go onto document its synthesis and subjective effects in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").

In the 1970s, it was used in patients by a small number of psychotherapists in the United States and was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature. It entered into recreational use shortly afterwards and was manufactured and sold commercially under names such as “Eros” and “Nexus” in head/smart shops and adult video stores before becoming federally prohibited by the DEA in 1995. Subjective effects include open and closed-eye visuals, time distortion, euphoria, and ego loss.

User reports typically describe the effects of 2C-B as moderate, warm, and highly sensual. It is usually described as having a less serious or grandiose headspace than LSD or psilocybin mushrooms, with a greater emphasis on visual and tactile effects. Smaller doses can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to MDMA) while larger doses produce a distinct classical psychedelic effect.

2C-B is thought to be well-tolerated physiologically, with a safety profile that appears to be similar to classical psychedelics. However, more research is needed to fully understand its toxicity and health risks. It is highly advised to use harm reduction practices if using this substance.

History

His findings were later published in his 1991 book PiHKAL, in which it was listed among the "magical half-dozen" of psychedelic phenethylamines that he deemed most important. The list consists of mescaline, DOM, 2C-B, 2C-E, 2C-T-2, and 2C-T-7. In interviews, Alexander Shulgin repeatedly declared it his favorite psychedelic trip. In the 1970s, 2C-B was used in patients by a small number of psychotherapists in the United States.

These therapists reported that it created a warm, empathetic bond between them and their patients, helping to break down their ego defenses and inner resistances and allowing the patient to get in touch with suppressed emotions and repressed memories. The gentle nature of 2C-B, in addition to its mild side effects and short duration, were found to be desirable traits for a therapeutic setting. Shortly after gaining traction in the underground psychotherapy community, 2C-B became popular in the recreational drug scene. 2C-B was well-liked as a MDMA substitute in raves and parties due to its minimal comedown and a clear, euphoric headspace.

In the 1980s and early 1990s, several foreign companies legitimately manufactured 2C-B under the brand names “Nexus”, “Erox”, and “Performax” and advertised that it would alleviate impotence, frigidity, and diminished libido. It was sold at adult book and video stores, “head” shops, and some nightclubs. The DEA reported its distribution in Miami, Florida as yellow pills marketed as an aphrodisiac. In the United States, 2C-B gained popularity as an alternative to MDMA following its classification as a Schedule I substance in 1985.

Its increasing popularity led it to be placed in Schedule I in 1995. It saw a resurgence in interest in the 2000s, with the advent of the research chemicals scene and darknet markets. 2C-B was legally sold in Southern Africa from 1993 to early 1996. It was marketed as medicine for Sangomas (traditional healers) under the name “Ubulawu Nomathotholo”, which roughly translates to “Medicine of the Singing Ancestors”.

Chemistry

2C-B

2C-B

Substituted phenethylamines are a chemical class of organic compounds that are based upon the phenethylamine structure, a phenyl ring bound to an amino (NH2) group through an ethyl chain.

2C-B possesses methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring. 2C-B belongs to the 2C family of phenethylamines, all of which possess methoxy groups on the 2 and 5 positions of the benzene ring.

Common NameMFT
Systematic nameMFT
FormulaC_{10}H_{14}BrNO_{2}
SMILESCOc1cc(c(cc1Br)OC)CCN
Std. InChiInChI=1S/C10H14BrNO2/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12/h5-6H,3-4,12H2,1-2H3
Std. InChiKeyYMHOBZXQZVXHBM-UHFFFAOYSA-N
Avg. Mass260.1277 Da
Molecular Weight260.1277
Monoisotopic Mass259.020782 Da
Nominal Mass259
ChemSpider ID88978

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Dosing Guide

Oral
Light5-15mg
Common15-30mg
Strong30-50mg
Heavy50mg+
Insufflated/Plugged
Light5-10mg
Common10-20mg
Strong20-30mg
Heavy30mg+

Duration

Oral
Onset20-75 minutes
Duration4-8 hours
After-effects2-4 hours

Interactions and Synergies

Caution

  1. Mescaline
  2. DOx
  3. NBOMes
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  8. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  9. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably

Dangerous

  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

General Information

Experiences
Oral
Vaporization
Come up
Dosage
Effectseuphoria, giggling, empathy, insight, brightened color, closed/open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception of time, ego softening, nausea, sweating/chills, muscle tension, confusion, insomnia
After Effects
Avoid
Warning
Risks
Test Kits
Marguis Test Result
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

Unlike most psychedelics, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor partial agonist or even full antagonist. This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B. Research also suggests that 2C-B increases dopamine levels in the brains of rats which may contribute to its psychoactivity. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical Effects

Psychological Effects

The cognitive effects of 2C-B are often described as both insightful and relatively normal in their thought processes even at moderate to high dosages. They are often described as being halfway between LSD and MDMA.

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry of 2C-B is more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of level 8A visual geometry over level 8B.

Hallucinatory states

Like LSD, while 2C-B is capable of producing a full range of low and high-level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower and generally includes the following effects:

Auditory Effects

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal Effects

While 2C-B has been reported as having the potential to produce transpersonal states, it is reported to occur less consistently or with less of a lasting impact than with classic psychedelics such as psilocybin mushrooms, mescaline, LSD, or DMT.

Legal Status

Internationally, 2C-B was added to the UN Convention on Psychotropic Substances as a Schedule II substance on March 20, 2001.

  • Argentina: 2C-B is a Schedule I controlled substance.
  • Australia: 2C-B is illegal to possess, produce and sell in Australia.
  • Austria: 2C-B is illegal to possess, produce and sell in Austria under the SMG (Suchtmittelgesetz Österreich).
  • Belgium: 2C-B is illegal to possess, produce and sell in Belgium.
  • Brazil: 2C-B is illegal to possess, produce and sell in Brazil as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-B is a Schedule III drug in Canada.
  • Croatia: 2C-B is illegal to possess, produce and sell in Croatia as a result of it being a 2,5-dimethoxyphenylethanamine.
  • Denmark: 2C-B is a List B controlled substance.
  • Estonia: 2C-B is a Schedule I drug in Estonia.
  • European Union: 2C-B is a Schedule II drug in the EU.
  • Finland: Possession, production and sale of 2C-B is illegal in Finland.
  • Germany: 2C-B is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of January 31, 1993. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Italy: 2C-B is a Schedule I (tabella I) drug in Italy
  • Japan: Possession, production and sale is illegal.
  • Latvia: 2C-B is a Schedule I controlled substance.
  • The Netherlands: Possession, production and sale is illegal.
  • Norway: 2C-B is a Schedule II drug.
  • Poland: 2C-B is a Schedule I drug.
  • Russia: Possession, production and sale is illegal.
  • Spain: 2C-B is a Category 2 drug.
  • Sweden: 2C-B is a Schedule I drug.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: 2C-B is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: 2C-B is a Schedule I drug.

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    Sources

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    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

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