Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

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This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

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Description

TMA-6 Also known as:

  • (±)-2,4,6-Trimethoxyamphetamine
  • (d,l)-2,4,6-Trimethoxyamphetamine
  • 1-(2,4,6-Trimethoxyphenyl)-2-amino-; propane Hydrochloride
  • 1-(2,4,6-Trimethoxyphenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(2,4,6-Trimethoxyphenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(2,4,6-Triméthoxyphényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(2,4,6-trimethoxyphenyl)propan-2-amine
  • 1-Methyl-2-(2,4,6-trimethoxyphenyl)ethylamine
  • 2,4,6-TRIMETHOXYAMPHETAMINE
  • Benzeneethanamine, 2,4,6-trimethoxy-α-methyl-[ACD/Index Name]
  • Benzenethanamine, 2,4,6-trimethoxy-α-methyl-, (±)-
  • (±)1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine
  • 1-(2,4,6-Trimethoxyphenyl)-2-amino-
  • 1-(2,4,6-Trimethoxyphenyl)-2-amino-propane Hydrochloride
  • 1-Methyl-2-(2,4,6-trimethoxy-phenyl)-ethylamine
  • 2,4,6-TRIMETHOXYAMPHETAMIN
  • 2,4,6-TRIMETHOXYAMPHETAMIN, >99% (HPLC)
  • amphetamine, 2,4,6-trimethoxy-
  • Benzeneethanamine, 2,4,6-trimethoxy-a-methyl- (9CI)
  • BENZENEETHANAMINE,2,4,6-TRIMETHOXY-A-METHYL-
  • Benzeneethanamine,2,4,6-trimethoxy-α-methyl-(±)-
  • Benzenethanamine, 2,4,6-trimethoxy-α-methyl-(±)-
  • CHEMBL34108
  • MFCD08452636
  • Phenethylamine, 2,4,6-trimethoxy-a-methyl- (6CI,8CI)

A rarely seen Psychedelic Amphetamine and Mescaline analogue. First synthesised by Alexander Shulgin, who descrived it as “one of the most rewarding and pleasurable of the methoxylated amphetamines.”

Summary

It has been reported to produce a complex mixture of stimulant, hallucinogenic and entactogenic effects that distinguish it from other psychedelic phenethylamine derivatives like the 2C-x or DOx series. TMA-6 has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the book PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin, who called it "one of the most rewarding and pleasurable of the methoxylated amphetamines". Since then it has been regarded as a novelty in the psychedelics community and is made available for sale only rarely by clandestine laboratory operations.

In terms of its subjective effects, it is known for its lack of classic psychedelic visuals compared to other hallucinogenic phenethylamines and is known instead for its unique stimulating body-high and intoxicating headspace. Anecdotal reports suggest that TMA-6 is unpredictable and dose-sensitive substance that can produce uncomfortable amounts of body load, nausea, overstimulation, and inconsistencies between experiences. In modern times, TMA-6 is used rarely as a recreational drug and a putative entheogen.

It has no documentation of being sold on the streets and is almost exclusively obtainable as an obscure gray area research chemical through the use of online vendors.

Chemistry

TMA-6

TMA-6

Amphetamines are substituted phenethylamines, being comprised of a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα.

TMA-6 contains methoxy functional groups CH3O- attached to carbons R2 and R4 and R6 of the amphetamine backbone.

Common Name2,4,6-TRIMETHOXYAMPHETAMINE
Systematic name2,4,6-TRIMETHOXYAMPHETAMINE
FormulaC_{12}H_{19}NO_{3}
SMILESCC(Cc1c(cc(cc1OC)OC)OC)N
Std. InChi
Std. InChiKey
Avg. Mass225.2842 Da
Molecular Weight225.2842
Monoisotopic Mass225.13649 Da
Nominal Mass225
ChemSpider ID28774

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Dose Chart

Oral
Threshold15-20mg
Light20-30mg
Common30-40mg
Heavy40-50mg+

Duration Chart

TMA-6 Duration Data
Onset60 minutes
Duration10-18 hours
After-effectsPossibility hours

Auditory Effects

Psychological Effects

The cognitive effects of TMA-6 are described as powerful mental stimulation along with undertones of intoxication that can increase the connectivity and rate of conceptual thinking without being overwhelming. The total sum of these cognitive components regardless of the setting generally includes:

Pharmacological Effects

TMA-6’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Physical Effects

  • Stimulation - In terms of its effects on the physical energy levels of the user, TMA-6 is usually considered to be extremely stimulating at levels which do not become overwhelming, resulting in a shakiness and unsteadiness of the hands but encouraging one to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
  • Spontaneous tactile sensations - The "body high" of TMA-6 is manifested as somewhat intense in comparison to most classical psychedelics such as LSD. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin, but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Tactile enhancement - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most TMA-6 trips.
  • Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the person has vomited or gradually fades by itself as the peak sets in.
  • Vasoconstriction - This effect is usually only present at higher dosages, but can be particularly uncomfortable.
  • Bodily control enhancement
  • Pupil dilation
  • Increased blood pressure

Subjective Effects

Visual Effects

Enhancements

Distortions

Legal Status

  • Germany: TMA-6 is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
  • Sources

    References

    1. https://www.erowid.org/library/books_online/pihkal/pihkal162.shtml
    2. https://www.erowid.org/library/books_online/pihkal/pihkal162.shtml
    3. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
    4. Gillman, P. K. (2005). Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British Journal of Anaesthesia, 95(4), 434-441. https://doi.org/10.1093/bja/aei210
    5. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
    6. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
    7. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.