Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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Psilocin Also known as:

  • 1H-Indol-4-ol, 3-[2-(dimethylamino)ethyl]-[ACD/Index Name]
  • 3-[2-(Dimethylamino)ethyl]-1H-indol-4-ol[ACD/IUPAC Name]
  • 3-[2-(Dimethylamino)ethyl]-1H-indol-4-ol[German][ACD/IUPAC Name]
  • 3-[2-(Diméthylamino)éthyl]-1H-indol-4-ol[French][ACD/IUPAC Name]
  • 4-hydroxy DMT
  • 4-OH-DMT
  • CMS88KUW0G
  • MFCD00079228
  • NM2625000
  • Psilocine
  • Psilocyn
  • Psilotsin
  • [520-53-6]
  • 3-(2-(dimethylamino)ethyl)-1H-indol-4-ol
  • 3-(2-(Dimethylamino)ethyl)indol-4-ol
  • 3-(2-dimethylaminoethyl)-1H-indol-4-ol
  • 3-(2-Dimethylaminoethyl)-4-hydroxyindole, N,N-Dimethyl-4-hydroxytryptamine
  • 3-[2-(Dimethylamino)ethyl]-Indol-4-ol
  • 5-22-12-00014 (Beilstein Handbook Reference)[Beilstein]
  • CHEMBL65547
  • CX 59
  • EINECS 208-296-5
  • Indol-4-ol, 3-(2-(dimethylamino)ethyl)-
  • Indol-4-ol, 3-[2-(dimethylamino)ethyl]-
  • N,N-dimethyl-4-hydroxytryptamine
  • NM 2625000
  • P-7800

Psilocin is a substutued tryptamine alkaloid, that is present in most psychedelic mushrooms. It is relatively unstable in solution due to the -OH group.


Psilocin is the primary psychoactive constituent in certain species of mushrooms, and as a closely related structural analog of the powerful visionary entheogen DMT (also known as N,N-dimethyltryptamine). Psilocin was first isolated and named by Albert Hofmann in 1958. Its psychoactivity is thought to emerge from the close chemical similarities with the neurotransmitter serotonin, which enables it to interact with a range of serotonin receptor sites throughout the brain that are integral for sensory and cognitive processes.

Notably, while psilocin naturally co-occurs with psilocybin in significant amounts of most psilocybin-containing mushrooms, it is only ever rarely encountered in its synthetic form. Anecdotal reports describe pure psilocin as a more lucid and aggressive version of psilocybin mushrooms. Unlike other highly prohibited substances, psilocin is not considered to be addictive or physiologically toxic.

Nevertheless, adverse psychological reactions such as severe anxiety, paranoia and psychosis are always possible, particularly among those predisposed to mental illness. It is highly advised to use harm reduction practices if using this substance.


Psilocin and its phosphorylated inactive precursor (i.e. prodrug) psilocybin were first isolated and named in 1958 by Swiss chemist Albert Hofmann. Hofmann obtained the chemicals from laboratory-grown specimens of the entheogenic mushroom Psilocybe mexicana before proceeding to find their synthetic routes.


Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.

4-HO-DMT is substituted at R4 of its indole heterocycle with an hydroxyl (-OH) functional group; it also contains two methyl groups CH3- bound to the terminal amine RN of the ethyl side chain.

This makes psilocin the 4-hydroxy structural analog of DMT, and dephosphorylated analog of psilocybin. Psilocin can be obtained by dephosphorylation of natural psilocybin under strongly acidic or under alkaline conditions via hydrolysis, which is how it becomes metabolically active in the human body as well. In terms of its physical properties, 4-HO-DMT is relatively unstable in solution due to its phenolic hydroxy (-OH) group.

In the presence of oxygen it readily forms bluish and dark black degradation products.

For this reason it is recommended to store it in optimal chemical storage conditions (i.e.

cool, dry, away from light) to avoid excessive degradation.

Common NamePsilocin
Systematic namePsilocin
Std. InChiInChI=1S/C12H16N2O/c1-14(2)7-6-9-8-13-10-4-3-5-11(15)12(9)10/h3-5,8,13,15H,6-7H2,1-2H3
Avg. Mass204.2682 Da
Molecular Weight204.2682
Monoisotopic Mass204.126266 Da
Nominal Mass204
ChemSpider ID4807

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Dose Chart


Duration Chart

Onset15-30 minutes
Duration3-6 hours
After-effects3-12 hours

Legal Status

Psilocin is a Schedule I drug under the Convention on Psychotropic Substances, meaning the possession and sale of it (including psilocin and psilocybin-containing mushrooms) is prohibited in most countries.

  • Belgium: Possession and sale of mushrooms have been illegal since 1988.
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344, but mushrooms fall under religious use laws.
  • British Virgin Isles: The sale of mushrooms is illegal, but possession and consumption is legal.
  • Bulgaria: The sale of mushrooms is illegal, but possession and consumption is legal.
  • Canada: Psilocybin and psilocin are illegal to possess, obtain or produce without a prescription or license as they are Schedule III under the Controlled Drugs and Substances Act.
  • Cyprus The possession, sale and consumption of mushrooms is illegal.
  • Czech Republic: The distribution (including sale) of mushrooms is illegal, but consumption is legal. The possession of over 40 hallucinogenic caps is considered a crime if they contain more than 50mg of psilocin or the corresponding amount of psilocybin. The possession of more than 40g of hallucinogenic mycelium is considered a crime. If these limits are not exceeded, the act is considered a minor offence and a fine of up to 15 thousand CZK may be imposed.
  • Denmark: The possession, growth, sale and consumption of mushrooms is illegal.
  • Finland: The possession, growth, sale and consumption of mushrooms is illegal.
  • Germany: Psilocin is controlled under Anlage I BtMG (Narcotics Act, Schedule I), former: Opiumgesetz (Opium Act) as of February 25, 1967. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Greece: The possession, growth, sale and consumption of mushrooms is illegal.
  • Ireland: The possession, growth, sale and consumption of mushrooms is illegal.
  • Japan: The possession, growth, sale and consumption of mushrooms is illegal.
  • Latvia: Hallucinogenic mushrooms, psilocin and psilocibyn are Schedule I controlled substances.
  • Mexico: The possession, growth, sale and consumption of mushrooms is illegal. Rules are relaxed regarding religious use however.
  • The Netherlands: The possession, growth, sale and consumption of mushrooms is illegal. However, due to a legal loophole, psilocybin truffles can be legally possessed, grown, sold and consumed.
  • New Zealand: Psilocybin is Class A.
  • Norway: Possession, growth, sale and consumption of mushrooms is illegal. Spores, even though not containing psilocybin, are also illegal.
  • Turkey: The possession, growth, sale and consumption of mushrooms is illegal.
  • United Kingdom: According to the 2005 Drugs Act, fresh and prepared psilocybin mushrooms are Class A.
  • United States: Psilocybin and psilocin are illegal Schedule I drugs.
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    3. PubChem National Center for Bio Informatics
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