Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

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Also known as:

  • 2-(3,5-Dimethoxy-4-propoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(3,5-Dimethoxy-4-propoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(3,5-Diméthoxy-4-propoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 4-propoxy-3,5-DMPEA
  • 99G781N5IO
  • Benzeneethanamine, 3,5-dimethoxy-4-propoxy-[ACD/Index Name]
  • 2-(3,5-dimethoxy-4-propoxyphenyl)ethan-1-amine
  • 2-(3,5-Dimethoxy-4-propoxy-phenyl)-ethylamine
  • MFCD12870983
  • UNII:99G781N5IO

A very uncommon psychedelic stimulant and phenethylamine and analogue on mescaline with similar effects. Roughly 5-7 times more potent than mescaline by weight.


It has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline. The synthesis of proscaline was first published by David E. Nichols in 1977.

Around the same time, Alexander Shulgin sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of mescaline. Shulgin later documented Proscaline in his 1991 book “PiHKAL: A Chemical Love Story”. Today, proscaline is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

It is relatively obscure and has only a short history of human use.





Proscaline contains two methoxy functional groups CH3O- which are attached to carbons R3 and R5 as well as an additional propyloxy group at carbon R4 of the phenyl ring.

Proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.

Common NameProscaline
Systematic nameProscaline
Std. InChiInChI=1S/C13H21NO3/c1-4-7-17-13-11(15-2)8-10(5-6-14)9-12(13)16-3/h8-9H,4-7,14H2,1-3H3
Avg. Mass239.3107 Da
Molecular Weight239.3107
Monoisotopic Mass239.152145 Da
Nominal Mass239
ChemSpider ID10439596

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Dosing Guide



Proscaline Duration Data
Onset30-60 minutes
Duration6-12 hours
After-effects3-5 hours

Interactions and Synergies

There are no existing interaction or synergy data for this drug.

General Information

Come up
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
Test Kits
Marguis Test Result
Note 2:
Note 3:


Pharmacological Effects

Proscaline’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective Effects

Physical Effects

Psychological Effects

Visual Effects




Hallucinatory states

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status


  1. Alexander Shulgin - PIHKAL |
  2. "Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.
  3. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 ( |
  4. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
  5. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  6. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.


Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.