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Description

Proscaline Also known as:

  • 2-(3,5-Dimethoxy-4-propoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(3,5-Dimethoxy-4-propoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(3,5-Diméthoxy-4-propoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 4-propoxy-3,5-DMPEA
  • 99G781N5IO
  • Benzeneethanamine, 3,5-dimethoxy-4-propoxy-[ACD/Index Name]
  • 2-(3,5-dimethoxy-4-propoxyphenyl)ethan-1-amine
  • 2-(3,5-Dimethoxy-4-propoxy-phenyl)-ethylamine
  • MFCD12870983
  • UNII:99G781N5IO

A very uncommon psychedelic stimulant and phenethylamine and analogue on mescaline with similar effects. Roughly 5-7 times more potent than mescaline by weight.

Summary

It has structural and pharmacological properties similar to its parent drug mescaline as well as to its analogs such as isoproscaline, escaline and allylescaline. The synthesis of proscaline was first published by David E. Nichols in 1977.

Around the same time, Alexander Shulgin sampled and evaluated the chemical at doses up to 60mg, estimating its potency as five times that of mescaline. Shulgin later documented Proscaline in his 1991 book “PiHKAL: A Chemical Love Story”. Today, proscaline is primarily used as a recreational drug, rarely if ever sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.

It is relatively obscure and has only a short history of human use.

Chemistry

Proscaline

Proscaline

Proscaline contains two methoxy functional groups CH3O- which are attached to carbons R3 and R5 as well as an additional propyloxy group at carbon R4 of the phenyl ring.

Proscaline is the 4-propyloxy analog of mescaline, which means it has one additional carbon at the alkyloxy group than escaline, another closely related mescaline analog.

Common NameProscaline
Systematic nameProscaline
FormulaC_{13}H_{21}NO_{3}
SMILESCCCOc1c(cc(cc1OC)CCN)OC
Std. InChiInChI=1S/C13H21NO3/c1-4-7-17-13-11(15-2)8-10(5-6-14)9-12(13)16-3/h8-9H,4-7,14H2,1-3H3
Std. InChiKeyHYWLMSUAZVDUFW-UHFFFAOYSA-N
Avg. Mass239.3107 Da
Molecular Weight239.3107
Monoisotopic Mass239.152145 Da
Nominal Mass239
ChemSpider ID10439596

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Dose Chart

Oral
Threshold15mg
Light15-30mg
Common30-40mg
Strong40-60mg

Duration Chart

Proscaline Duration Data
Onset30-60 minutes
Duration6-12 hours
After-effects3-5 hours

Auditory Effects

Psychological Effects

Pharmacological Effects

Proscaline’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Physical Effects

Subjective Effects

Visual Effects

Enhancements

Distortions

Geometry

Hallucinatory states

Legal Status

Sources

References

  1. Alexander Shulgin - PIHKAL | http://www.erowid.org/library/books_online/pihkal/pihkal140.shtml
  2. "Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues." Nichols DE, Dyer DC. J Med Chem. 1977 Feb;20(2):299-301.
  3. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p209 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
  4. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
  5. "Anlage NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
  6. "§ 4 NpSG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.