Mescaline

Mescaline

Mescaline

Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

This is a commonly used substance with well known and widely available human consumption data. This does not guarantee that the substance will be safe. The safety profile has been established based on usage data commonly available.

Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Practice Harm Reduction. Proceed with Caution.

Description

Mescaline

Also known as:

  • 2-(3,4,5-Trimethoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(3,4,5-Trimethoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(3,4,5-Triméthoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 2-(3,4,5-Trimethoxyphenyl)ethylamine
  • 3,4,5-Trimethoxy-b-phenethylamine
  • Benzeneethanamine, 3,4,5-trimethoxy-[ACD/Index Name]
  • 1-amino-2-(3,4,5-trimethoxyphenyl)ethane
  • 2-(3,4,5-TRIMETHOXYPHENYL)-ETHYLAMINE
  • 3,4, 5-Trimethoxyphenethylamine
  • 3,4,5-Triaminopyridine
  • 3,4,5-Trimethoxybenzeneethanamine
  • 3,4,5-trimethoxyphenethylamine
  • 3,4,5-Trimethoxy-phenylethylamine
  • 3,4,5-TRIMETHOXYPHENYLETHYLAMINE
  • 3,4,5-TRIMETHOXY-β-PHENETHYLAMINE
  • Ethane, 1-amino-2-(3, 4,5-trimethoxyphenyl)-
  • Ethane, 1-amino-2-(3,4,5-trimethoxyphenyl)-
  • Mescalin
  • Mescalin [German]
  • mescalina
  • Mescline
  • Meskalin
  • Mezcalin
  • mezcalina
  • Mezcaline
  • Mezcline
  • MFCD00128240[MDL number]
  • Phenethylamine, 3,4,5-trimethoxy-
  • Tmpea
  • WLN: Z2R CO1 DO1 EO1
  • β-D

A psychedelic of the phenethylamine family. Found in psychedelic cacti that have long been used by peoples native to the Southwestern US and Mexico, including Peyote and San Pedro cacti, among others. Can be found as cactus pulp, as an extract from cacti, or as a synthetic substance created in a lab.

Summary

It occurs naturally in the peyote cactus (Lophophora williamsii), and a number of other cacti species such as the Echinopsis pachanoi (San Pedro cactus), Echinopsis peruviana (Peruvian Torch) as well as the Cactaceae plant and the Fabaceae bean family. It is one of the oldest known hallucinogens and is the prototypical member of the psychedelic phenethylamines, one of the two major classes of psychedelics (along with tryptamines). Mescaline was first isolated from peyote in 1897 by the German chemist.

The ritual use of the peyote cactus has occurred for at least 5700 years by Native Americans in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in the South American continent, spanning from Peru to Ecuador. Mescaline is an important part of the life’s work of the American chemist Alexander Shulgin, who used mescaline as a starting point for synthesizing dozens of novel psychedelic compounds, which he documented in the 1991 book PiHKAL (“Phenethylamines I Have Known and Loved”).

Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss. It is considered to be one of the most gentle, subtle, and euphoric psychedelics, with a greater emphasis on bodily and tactile sensations (somewhat similar to MDMA) than tryptamines like psilocybin or DMT, which tend to have a more dynamic head-space and visual geometry. Synthetic mescaline is highly sought after and typically produced only in small batches, owing to its low potency and relatively high production cost.

Unlike other highly prohibited substances, mescaline has not been proven to be physiologically toxic or addictive. Nevertheless, adverse psychological reactions such as anxiety, paranoia, delusions and psychosis can still always occur, particularly among those predisposed to mental disorders. It is highly advised to use harm reduction practices if using this substance.

History

Upon early contact, Europeans noted the use of Peyote in Native American religious ceremonies. Additionally, alternative mescaline-containing cacti such as the San Pedro have a long history of use in the South American continent, spanning from Peru to Ecuador. The principal psychoactive component in both Peyote and San Pedro, mescaline, was first isolated and identified in 1897 by the German chemist Arthur Heffter and first synthesized in 1919 by Ernst Späth. In traditional peyote preparations, the top of the cactus is cut at ground level, leaving the large tap roots to grow new 'heads'. These 'heads' are then dried to make disc-shaped buttons and the buttons are chewed to produce the effects or soaked in water to drink.

In modern times, users will often grind it into a powder and pour it into gel capsules to avoid having to come into contact with the bitter taste of the cactus. The usual human dose is 200–400 milligrams of mescaline sulfate or 178–356 milligrams of mescaline hydrochloride. The average 76 mm (3.0 in.) button contains about 25 mg mescaline. Mescaline is an important part of the life’s work of Alexander Shulgin, a psychedelic chemist and researcher.

Shulgin used mescaline as a starting point for synthesizing dozens of novel psychedelic phenethylamine compounds such as the 2C-x and DOx families. It is a member of the so-called “magical half-dozen” which refers to Shulgin’s self-rated most important phenethylamine compounds with psychedelic activity, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.

Chemistry

Mescaline

Mescaline

Mescaline contains three methoxy functional groups CH3O- which are attached to carbons R3, R4, and R5 of the phenyl ring.

Common NameMescaline
Systematic nameMescaline
FormulaC_{11}H_{17}NO_{3}
SMILESCOc1cc(cc(c1OC)OC)CCN
Std. InChiInChI=1S/C11H17NO3/c1-13-9-6-8(4-5-12)7-10(14-2)11(9)15-3/h6-7H,4-5,12H2,1-3H3
Std. InChiKeyRHCSKNNOAZULRK-UHFFFAOYSA-N
Avg. Mass211.2576 Da
Molecular Weight211.2576
Monoisotopic Mass211.12085 Da
Nominal Mass211
ChemSpider ID3934

Subscribe for the latest updates

Dosing Guide

Oral
Threshold100mg
Light100-200mg
Common200-300mg
Strong300-500mg
Heavy500-700mg+

Duration

Mescaline Duration Data
Onset60-180 minutes
Duration6-12 hours
After-effects3-5 hours

Interactions and Synergies

Caution

  1. DOx
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
  8. Cocaine
    • The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
  9. MAOIs

Dangerous

  1. Tramadol
    • This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.

No Synergy

  1. Caffeine
    • High doses of caffeine are uncomfortable and this will be magnified by psychedelics
  2. Opioids

General Information

Experiences
Oral
Vaporization
Come up
Dosage
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
Avoid
Warning
Risks
Test Kits
Marguis Test ResultStrong orange
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

Mescaline acts similarly to other psychedelic agents. It binds to and activates the serotonin 5-HT2A receptor with a high affinity. How activating the 5-HT2A receptor leads to psychedelia is still unknown, but it likely somehow involves excitation of neurons in the prefrontal cortex. Mescaline is also known to bind to and activate the serotonin 5-HT2C receptor.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical Effects

  • Stimulation - Mescaline is usually considered to be very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
  • Spontaneous bodily sensations - The "body high" of mescaline can be described as proportionally intense in comparison to its accompanying visual and cognitive effects. It is manifested in a number of forms including an intense soft, warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is most similar to MDMA and psilocin and is consistently manifested throughout the experience. This is contrasted by an intensely pleasurable yet sharp, cold electric tingling sensation which moves up and down the body. This is most similar to LSD and is also consistently manifested throughout the experience. The final physical effect noticed throughout the experience is an intense energetic pins and needles sensation that manifests itself in the form of a continuously shifting and tingling sensation that travels up and down the body in spontaneous waves. This is most similar to 2C-B and is not entirely consistent throughout the experience.
    • Physical euphoria - Relative to other psychedelics, mescaline has been noted for the bodily or physically euphoric aspect that is vaguely reminiscent of other phenethylamines like MDA.
  • Nausea - Nausea is commonly reported when consumed in moderate to high doses and either passes instantly once the user has vomited or gradually fades by itself as the peak sets in.
  • Increased salivation - This effect, while uncommon, seems to be less pronounced than it is with psilocin and other tryptamines and usually does not persist throughout the experience.
  • Tactile enhancement - Feelings of enhanced tactile sensations are consistently present at moderate levels. If Level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once is consistently present.
  • Appetite suppression
  • Bodily control enhancement
  • Stamina enhancement
  • Olfactory enhancement
  • Frequent urination
  • Increased heart rate
  • Increased libido
  • Muscle contractions
  • Pupil dilation
  • Seizure - A rarely observed effect but is thought to be able to happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.

Psychological Effects

In comparison to other psychedelics such as psilocin, LSA and ayahuasca, mescaline is significantly more stimulating and fast-paced in terms of the specific style of thought stream produced and contains a large number of potential effects.

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry encountered on mescaline can be described as similar in appearance to that of ayahuasca, 2C-P or psilocin in the sense that its geometry is structured in its organization as well as natural and organic in style. However, in terms of its bright colors, sharp edges and angular corners, it is more similar to that of LSD, 2C-B and 2C-I.

The geometry can be comprehensively described as:

Hallucinatory states

Mescaline is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.

Auditory Effects

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Transpersonal Effects

Legal Status

Internationally, mescaline is classified as a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in mescaline is supposed to be closely monitored and its use is supposed to be restricted to scientific research and medical use. Natural materials containing mescaline, including peyote, are not regulated under the 1971 Psychotropic Convention.

  • Australia: Peyote cacti and other mescaline-containing plants, such as San Pedro, are illegal in Western Australia, Queensland, and the Northern Territory. In other states such as Victoria and New South Wales, they are legal for ornamental and gardening purposes.
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: Mescaline is classified as a Schedule III drug under the Controlled Drugs and Substances Act. Peyote is listed as an exemption. Other mescaline containing plants are presumably illegal to possess outside of ornamental and gardening purposes.
  • Germany: Mescaline is controlled under Anlage I BtMG (Narcotics Act, Schedule I), former: Opiumgesetz (Opium Act) as of February 25, 1967. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • The Netherlands: Mescaline in its raw form and dried mescaline-containing cacti are considered an illegal drug. However, anyone may grow and use peyote without restriction as it is specifically exempt from legislation.
  • United Kingdom: Mescaline in purified powder form is a Class A drug. However, dried cactus can be bought and sold legally.
  • United States: Mescaline was made illegal in 1970 by the Comprehensive Drug Abuse Prevention and Control Act. The drug is categorized as a Schedule I hallucinogen by the CSA. Mescaline is legal only for certain religious groups (such as the Native American Church) and in scientific and medical research. While mescaline containing cacti of the genus Echinopsis are technically controlled substances under the Controlled Substances Act, they are commonly sold publicly as ornamental plants.

  • References

    1. Nichols, D. E. (2016). Psychedelics, (April), 264–355. https://doi.org/10.1124/pr.115.011478
    2. Drug Identification Bible. Grand Junction, CO: Amera-Chem, Inc. 2007. ISBN 0-9635626-9-X.
    3. http://catbull.com/alamut/Bibliothek/1973_d.m._crosby_8158_1.pdf | Cactus Alkaloids. XIX. Crystallization of Mescaline HC1 and 3-Methoxytyramine HC1 from Trichocereus pachanoi
    4. http://catbull.com/alamut/Bibliothek/chem of texas acacias.pdf | Chemistry of Acacia's from South Texas
    5. https://www.erowid.org/culture/characters/heffter_arthur/heffter_arthur.shtml
    6. http://www.ncbi.nlm.nih.gov/pubmed/15990261 | Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas.
    7. Lüscher, C., & Ungless, M. A. (2006). The Mechanistic Classification of Addictive Drugs, 3(11). https://doi.org/10.1371/journal.pmed.0030437
    8. Strassman, R. J. (1984). Adverse reactions to psychedelic drugs. A review of the literature. The Journal of Nervous and Mental Disease, 172(10), 577-595. PMID: 6384428
    9. http://www.ncbi.nlm.nih.gov/pubmed/15990261 | Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas.
    10. https://www.erowid.org/culture/characters/heffter_arthur/heffter_arthur.shtml
    11. https://www.erowid.org/archive/rhodium/chemistry/mescaline.alkaloids.html
    12. https://www.erowid.org/library/books_online/pihkal/pihkal096.shtml | https://www.erowid.org/library/books_online/pihkal/pihkal096.shtml
    13. AJ Giannini, AE Slaby, MC Giannini (1982). Handbook of Overdose and Detoxification Emergencies. New Hyde Park, NY.: Medical Examination Publishing Company. ISBN 978-0-87488-182-0
    14. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "PIHKAL". Retrieved April 14, 2017.
    15. http://www.ncbi.nlm.nih.gov/pubmed/14761703 | Mescaline
    16. http://www.ncbi.nlm.nih.gov/pubmed/9301661 | Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives.
    17. http://www.ncbi.nlm.nih.gov/pubmed/17535909 | Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex.
    18. https://www.erowid.org/psychoactives/pharmacology/pharmacology_article1.shtml
    19. http://www.mescaline.com/sanpedro/
    20. "Erowid Cacti Vaults : Visionary Cactus Guide - Mescaline from Sawdust". Retrieved 14 January 2015.
    21. "Descriptions of psychoactive Cacti". Retrieved 14 January 2015.
    22. "Cactus Chemistry By Species" (PDF).
    23. Forbidden Fruit Archives
    24. "Partial List of Alkaloids in Trichocereus Cacti". Thenook.org. Retrieved 2013-10-14.
    25. Trichocereus
    26. Partial List of Alkaloids in Trichocereus Cacti
    27. "Echinopsis tacaquirensis ssp. taquimbalensis". Retrieved 14 January 2015.
    28. "Cardon Grande (Echinopsis terscheckii)". Retrieved 14 January 2015.
    29. Lycaeum
    30. Austrocylindropuntia cylindrica <http://www.desert-tropicals.com>
    31. "Cane Cholla (Cylindropuntia spinosior)". Retrieved 14 January 2015.
    32. Psychedelics and Society by Michael Valentine Smith | https://www.erowid.org/archive/rhodium/chemistry/psychedelicchemistry/chapter1.html
    33. "Convention On Psychotropic Substances, 1971" (PDF). United Nations Office on Drugs and Crime. Retrieved January 3, 2020.
    34. http://portal.anvisa.gov.br/documents/10181/3115436/(1)RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
    35. http://laws-lois.justice.gc.ca/Search/Search.aspx?txtS3archA11=mescaline&txtT1tl3="Controlled Drugs and Substances Act"&h1ts0n1y=0&ddC0nt3ntTyp3=Acts.
    36. "Vierte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    37. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    38. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    39. http://www.erowid.org/plants/cacti/cacti_law2.shtml
    40. http://www.deadiversion.usdoj.gov/schedules/index.html | List of Controlled Substances

    Resources

    1. 1717 CheMall OR052244
    2. 1717 CheMall OR146516
    3. 1717 CheMall OR194297
    4. A&J Pharmtech AJ-08069
    5. A&J Pharmtech AJ-143283
    6. abcr AB466401
    7. ACToR: Aggregated Computational Toxicology Resource 54-04-6
    8. Advanced Technology & Industrial 3580900
    9. AKos AKOS000277426
    10. ALK ALG00158506
    11. Angene AG-A-47573
    12. Angene AGN-PC-0786UH
    13. Ark Pharm, Inc. AK153291
    14. Aurora Fine Chemicals A00.555.223
    15. Aurora Fine Chemicals K02.874.567
    16. Bide Pharmatech BD167979
    17. BIND (no longer updated) 332
    18. Biosynth W-204256
    19. Biosynth Carbosynth FT55211
    20. Cambridge Chem CC167997
    21. CambridgeSoft Corporation 6182
    22. ChEBI
    23. ChEBI CHEBI:28346
    24. ChemAdvisor OHS14045
    25. ChemAdvisor OHS14045
    26. ChemBank DivK1c_000984
    27. ChemBank KBio1_000984
    28. ChemBank NINDS_000984
    29. ChEMBL CHEMBL26687
    30. ChemDB 3967410
    31. ChemIDplus 000054046
    32. ChemIDplus 54046
    33. Chemspace CSC017304756
    34. ChemSynthesis 26966
    35. Collaborative Drug Discovery 41509
    36. DiscoveryGate 4076
    37. DSigDB d4ttd_9210
    38. DTP/NCI 172790
    39. DTP/NCI 30419
    40. eMolecules 872968
    41. EPA DSSTox DTXCID40124794
    42. Erowid Mescaline
    43. FDA UNII - NLM RHO99102VC
    44. FDA UNII - NLM UNII: RHO99102VC
    45. Fluorochem 456477
    46. iChemical EBD70994
    47. Jean-Claude Bradley Open Melting Point Dataset 21758
    48. KEGG C06546
    49. LabNetwork LN02026819
    50. Laboratory Chemical Safety Summary 4076
    51. LeadScope LS-103730
    52. MassBank JP002801
    53. MassBank JP003173
    54. Molport MolPort-046-156-478
    55. NIST Chemistry WebBook 2081574550
    56. NIST Spectra mainlib_246201
    57. NIST Spectra nist ri
    58. NIST Spectra replib_246204
    59. Parchem – fine & specialty chemicals 132834
    60. PubChem 4076
    61. PubMed 116281
    62. PubMed 1197576
    63. PubMed 14214423
    64. PubMed 14516493
    65. PubMed 2314063
    66. PubMed 2901488
    67. PubMed 4210779
    68. PubMed 5095413
    69. PubMed 5631690
    70. PubMed 5778154
    71. PubMed 8383816
    72. Royal Society of Chemistry b200607c
    73. RSC Learn Chemistry Wiki Mescaline
    74. Sabio-RK 8717
    75. Springer Nature 5HT-2 mediation of acute behavioral effects of hallucinogens in rats
    76. Springer Nature 6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits
    77. Springer Nature A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats
    78. Springer Nature A note on some therapeutic implications of the mescaline-induced state
    79. Springer Nature A relationship between hexobarbitone sleeping time and susceptibility to mescaline in mice from different strains
    80. Springer Nature A scanning and computing microphotometer for cell analyses
    81. Springer Nature Acetylation of mescaline in rat brains
    82. Springer Nature Actions of noradrenaline and mescaline on cortical neurones
    83. Springer Nature Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine
    84. Springer Nature An assay procedure for mescaline and its determination in rat brain, liver and plasma
    85. Springer Nature Analysis of illicit drugs by nonaqueous capillary electrophoresis and electrochemical detection
    86. Springer Nature Autoradiographic studies on the distribution of 3H-2,3,4-trimethoxy-??-phenylethylamine in the mouse
    87. Springer Nature Autoradiographische Untersuchungen zur Verteilung von Mescalin und dessen Einflu?? auf die zentrale Erregung bei M??usen
    88. Springer Nature Behavioral observations on compounds found in nutmeg
    89. Springer Nature Beta-adrenergic blocking agents as potent antagonists of mescaline-induced contractions in the rat uterus
    90. Springer Nature Comparison of psilocin with psilocybin, mescaline and LSD-25
    91. Springer Nature Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine
    92. Springer Nature Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions
    93. Springer Nature Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates
    94. Springer Nature De novo sequencing and analysis of Lophophora williamsii transcriptome, and searching for putative genes involved in mescaline biosynthesis
    95. Springer Nature Development of tolerance to the antinociceptive effect of mescaline intraventricularly administered to rabbits
    96. Springer Nature Differences in tolerance to mescaline produced by peripheral and direct central administration
    97. Springer Nature Does increasing stress change the behavioral action of mescaline from disruption to facilitation?
    98. Springer Nature Effect of benzodiazepines on central serotonergic neuron systems
    99. Springer Nature Effect of chronic treatment with mescaline upon tissue levels of the drug
    100. Springer Nature Effect of clozapine and molindone on plasma and brain levels of mescaline in mice
    101. Springer Nature Effect of deglycyrrhizinized liquorice on gastric acid secretion, histidine decarboxylase activity and serum gastrin level in the rat
    102. Springer Nature Effect of mescaline, lysergic acid diethylamide and psilocybin on color perception
    103. Springer Nature Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements
    104. Springer Nature Effects of mescaline and amphetamine on simultaneous visual discrimination in two inbred strains of mice
    105. Springer Nature Effects of mescaline and psilocin on acquisition, consolidation, and performance of light-dark discrimination in two inbred strains of mice
    106. Springer Nature Effects of yohimbine and mescaline on punished behavior in the rat
    107. Springer Nature Electroencephalographic studies on the development of tolerance and cross tolerance to mescaline in the rat
    108. Springer Nature Facilitation and disruption by mescaline and 3,4-dimethoxyphenylethylamine of shock avoidance in rats
    109. Springer Nature Fluorodensitometric determination of compounds containing primary amino groups with o-phthalaldehyde after separation by HPTLC
    110. Springer Nature Hallucinogenic agents as discriminative stimuli: A correlation with serotonin receptor affinities
    111. Springer Nature Hapten-immunological studies on mescaline
    112. Springer Nature Head twitches induced by benzodiazepines and the role of biogenic amines
    113. Springer Nature Inescapable shock alters mescaline's disruption of active avoidance acquisition
    114. Springer Nature Influence of (???) ??9-trans-tetrahydrocannabinol and mescaline on the behavior of rats submitted to food competition situations
    115. Springer Nature Interaction of stress and psychotomimetic drug-action: Possible implication for psychosis
    116. Springer Nature Lack of cross-tolerance in rats among (???) ??9-trans-tetrahydrocannabinol (??9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25)
    117. Springer Nature LC-PAD Determination of Mescaline in Cactus u201cPeyoteu201d (Lophophora williamsii)
    118. Springer Nature Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties
    119. Springer Nature Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
    120. Springer Nature Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose
    121. Springer Nature Mescaline-induced changes of brain-cortex ribosomes
    122. Springer Nature Mescaline-induced changes of brain-cortex ribosomes mescaline demethylase activity of brain-cortex soluble supernatant
    123. Springer Nature Mescaline: Apotheosis of u2018The devilu2019s rootu2019
    124. Springer Nature Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists
    125. Springer Nature Mescaline: Its effects on learning rate and dopamine metabolism in goldfish (Carassius auratus)
    126. Springer Nature Metabolic fate of mescaline in man
    127. Springer Nature Modification of the effect of some central stimulants in mice pretreated with ??-methyl-l-tyrosine
    128. Springer Nature Morphine, mescaline and cocaine on water maze discrimination in mice
    129. Springer Nature Neue Beobachtungen ??ber die physiologische Wirkung des Mescalins
    130. Springer Nature paraChlorophenylalanine potentiates facilitatory effects of mescaline on shuttlebox escape/avoidance in rats
    131. Springer Nature Peyote identification on the basis of differences in morphology, mescaline content, and trnL/trnF sequence between Lophophora williamsii and L. diffusa
    132. Springer Nature Pharmacokinetic parameters of mescaline in rabbits
    133. Springer Nature Physiological disposition of ??-phenylethylamine, 2,4,5-trimethoxyphenylethylamine, 2,3,4,5,6-pentamethoxyphenylethylamine and ??-hydroxymescaline in rat brain, liver and plasma
    134. Springer Nature Possible biosynthesis of D-lysergic acid diethylamide-like compounds from mescaline
    135. Springer Nature Potentiation of histamine and inhibition of diamine oxidase by mescaline
    136. Springer Nature Prolongation of hexobarbital-hypnosis in mice by iproniazid, serotonin, and reserpine
    137. Springer Nature Prolonged reactions to mescaline
    138. Springer Nature Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for u2018hallucinogensu2019
    139. Springer Nature Quantitative analysis of phenethylamine derivatives by thin layer chromatography. Determination of psychotropic drugs and ephedra bases
    140. Springer Nature Quipazine-induced stimulus control in the rat
    141. Springer Nature Regional localization of [14C]mescaline in rabbit brain after intraventricular administration
    142. Springer Nature Severe aggression in rats induced by mescaline but not other hallucinogens
    143. Springer Nature Similarity between D-serotonin receptors and ??-adrenergic receptors
    144. Springer Nature Some neurochemical and neuropharmacological studies on the interactions between mescaline and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC)
    145. Springer Nature Stimulation of human prolactin secretion by mescaline
    146. Springer Nature Stimulus properties of mescaline and N-methylated derivatives: Difference in peripheral and direct central administration
    147. Springer Nature Structure-activity relationship studies on mescaline
    148. Springer Nature Structure-activity relationship studies on mescaline: II. Tolerance and Cross-tolerance between mescaline and its analogues in the rat
    149. Springer Nature Structure-activity relationship studies on mescaline: The effect of dimethoxyphenylethylamine and N:N-dimethyl mescaline on the conditioned avoidance response in the rat
    150. Springer Nature Studies on mescaline I. Action in schizophrenic patients
    151. Springer Nature Studies on mescaline II. Electro-encephalogram in schizophrenics
    152. Springer Nature Studies on mescaline III. Action in epileptics
    153. Springer Nature Studies on mescaline XI: Biochemical findings during the mescaline-induced state with observations on the blocking action of different psychotropic drugs
    154. Springer Nature The action of tryptamine on the dog spinal cord and its relationship to the agonistic actions of LSD-like psychotogens
    155. Springer Nature The effect of LSD, mescaline, and D-amphetamine on the evoked u201csecondary dischargeu201d
    156. Springer Nature The effect of mescaline upon the conditioned avoidance response in the rat
    157. Springer Nature The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus
    158. Springer Nature The relative effectiveness of several hallucinogens in disrupting maze performance by rats
    159. Springer Nature Tolerance and cross-tolerance among psychotomimetic drugs
    160. Springer Nature Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration
    161. The Merck Index Online cs000000012073
    162. Thieme Chemistry 10.1055/s-0031-1290655
    163. Thomson Pharma 00056650
    164. Wikidata Q193140
    165. Wikipedia Mescaline
    166. ZINC ZINC00001689

    Sources

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.