DON

DON

DON

Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

Experimental drugs have extremely limited human consumption data. There is not enough reliable information about this substance. This is most likely because the substance is is not very old. Information on these substances is limite and incomplete. Please be cautioned. Always practice harm reduction.

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Description

DON

Also known as:

  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(2,5-Diméthoxy-4-nitrophényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(2,5-dimethoxy-4-nitrophenyl)propan-2-amine
  • 2,5-DIMETHOXY-4-NITROAMPHETAMINE
  • Benzeneethanamine, 2,5-dimethoxy-α-methyl-4-nitro-[ACD/Index Name]
  • (-)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • (±)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine((R)-(-)-DON)
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine(DON)
  • DON

A very rare psychedelic Amphetamine. That is more rough on the body then other DOx compounds. Making it physically painful in some cases.

Summary

History

Chemistry

DON

DON

Common Name2,5-DIMETHOXY-4-NITROAMPHETAMINE
Systematic name2,5-DIMETHOXY-4-NITROAMPHETAMINE
FormulaC_{11}H_{16}N_{2}O_{4}
SMILESCC(Cc1cc(c(cc1OC)[N+](=O)[O-])OC)N
Std. InChiInChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
Std. InChiKeyLINOMUASTDIRTM-QGRHZQQGSA-N
Avg. Mass240.2557 Da
Molecular Weight240.2557
Monoisotopic Mass240.111008 Da
Nominal Mass240
ChemSpider ID95083

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Dosing Guide

Threshold:
Threshold2mg
Light3mg
Common3-5mg
Heavy5mg+

Duration

DON Duration Data
Onset30-120 minutes
Duration14-22 hours
After-effects12-24 hours

Interactions and Synergies

Caution

  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably

Dangerous

  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

General Information

Experiences
Oral
Vaporization
Come up
Dosage
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
Avoid
Warning
Risks
Test Kits
Marguis Test Result
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

Subjective Effects

Physical Effects

Psychological Effects

Visual Effects

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status


References

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    Sources

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.