Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

Experimental drugs have extremely limited human consumption data. There is not enough reliable information about this substance. This is most likely because the substance is is not very old. Information on these substances is limite and incomplete. Please be cautioned. Always practice harm reduction.

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Also known as:

  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(2,5-Diméthoxy-4-nitrophényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(2,5-dimethoxy-4-nitrophenyl)propan-2-amine
  • Benzeneethanamine, 2,5-dimethoxy-α-methyl-4-nitro-[ACD/Index Name]
  • (-)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • (±)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine((R)-(-)-DON)
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine(DON)
  • DON

A very rare psychedelic Amphetamine. That is more rough on the body then other DOx compounds. Making it physically painful in some cases.






Std. InChiInChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
Avg. Mass240.2557 Da
Molecular Weight240.2557
Monoisotopic Mass240.111008 Da
Nominal Mass240
ChemSpider ID95083

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Dosing Guide



DON Duration Data
Onset30-120 minutes
Duration14-22 hours
After-effects12-24 hours

Interactions and Synergies


  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

General Information

Come up
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
Test Kits
Marguis Test Result
Note 2:
Note 3:


Pharmacological Effects

Subjective Effects

Physical Effects

Psychological Effects

Visual Effects

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status



    1. abcr AB259466
    2. Advanced Technology & Industrial 3573165
    3. AK Scientific 8525AJ
    4. AKos AKOS024457908
    5. Alfa Chemistry 51481-10-8
    6. Ambeed A411475
    7. ApexBio B7557
    8. Apollo Scientific Limited BID1001
    9. Apollo Scientific Limited BIMS109
    10. Ark Pharm, Inc. AK326173
    11. Aurora Fine Chemicals K02.108.873
    12. Bide Pharmatech BD123774
    13. BLDpharm BD123774
    14. BOC Sciences 51481-10-8
    15. CambridgeSoft Corporation 10242
    16. ChEMBL CHEMBL513300
    17. ChemIDplus 051481108
    18. ChemScene 51481-10-8
    19. CSDeposition Service BID1001
    20. DiscoveryGate 40024
    21. DSigDB d4ctd_341
    22. eMolecules 474371
    23. EPA DSSTox 398_CPDBAS_v5b
    24. EPA DSSTox DTXCID50382
    25. FDA UNII - NLM JT37HYP23V
    27. Glentham Life Sciences GP1680
    28. Jean-Claude Bradley Open Melting Point Dataset 22639
    29. LabNetwork LN01267845
    30. Laboratory Chemical Safety Summary 40024
    31. Labseeker SC-94746
    32. LeadScope LS-157038
    33. LGC Standards DRE-A12147000AL-100
    34. LGC Standards DRE-C12147000
    35. LGC Standards DRE-C12147000-10MG
    36. LGC Standards DRE-C12147000-5MG
    37. LGC Standards DRE-V12147000AL-100
    38. MassBank AC000110
    39. MassBank AC000111
    40. MassBank AC000112
    41. MassBank AC000113
    42. MassBank AC000114
    43. Mcule MCULE-5992308149
    44. Molport MolPort-003-925-048
    45. Molport MolPort-046-588-673
    46. MuseChem R058378
    47. PDB 3J6
    48. Phion 69480201
    49. PubChem 40024
    50. Royal Society of Chemistry b711352h
    51. Ryan Scientific 107-58375
    52. Santa Cruz Biotechnology sc-204711
    53. Sigma-Aldrich 32943
    54. Sigma-Aldrich 34124
    55. Sigma-Aldrich 46911
    56. Sigma-Aldrich CRM46911
    57. Sigma-Aldrich D0156
    58. Sigma-Aldrich IRMM315
    59. Sigma-Aldrich SIAL-32943
    60. Sigma-Aldrich SIAL-34124
    61. Sigma-Aldrich SIAL-IRMM315
    62. Sigma-Aldrich SIGMA-D0156
    63. Sigma-Aldrich SUPELCO-46911
    64. Sigma-Aldrich SUPELCO-CRM46911
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    105. Springer Nature Effects of oral deoxynivalenol exposure on immune-related parameters in lymphoid organs and serum of mice vaccinated with porcine parvovirus vaccine
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    109. Springer Nature Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process
    110. Springer Nature Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs
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    120. Springer Nature Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-??-d-glucoside
    121. Springer Nature Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig
    122. Springer Nature Method of analysis for deoxynivalenol and zearalenone from cereal grains
    123. Springer Nature Microbial biotransformation of DON: molecular basis for reduced toxicity
    124. Springer Nature Modelling within-field variations in deoxynivalenol (DON) content in oats using proximal and remote sensing
    125. Springer Nature Modified use of a commercial ELISA kit for deoxynivalenol determination in rice and corn silage
    126. Springer Nature Molecular cloning and characterization of an up-regulated UDP-glucosyltransferase gene induced by DON from Triticum aestivum L. cv. Wangshuibai
    127. Springer Nature Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa
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    131. Springer Nature null
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    133. Springer Nature Occurrence of Fusarium head blight (FHB) in southern NSW in 2000: identification of causal fungi and determination of putative chemotype of Fusarium graminearum isolates by PCR
    134. Springer Nature On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation
    135. Springer Nature On the effects ofFusarium-contaminated wheat and the feed intake level on ruminal fermentation and toxin-turnover of cows
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    160. Wikidata Q420518
    161. Wikipedia Vomitoxin


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    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
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