Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

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DON Also known as:

  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(2,5-Dimethoxy-4-nitrophenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(2,5-Diméthoxy-4-nitrophényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(2,5-dimethoxy-4-nitrophenyl)propan-2-amine
  • Benzeneethanamine, 2,5-dimethoxy-α-methyl-4-nitro-[ACD/Index Name]
  • (-)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • (±)2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine((R)-(-)-DON)
  • 2-(2,5-Dimethoxy-4-nitro-phenyl)-1-methyl-ethylamine(DON)
  • DON

A very rare psychedelic Amphetamine. That is more rough on the body then other DOx compounds. Making it physically painful in some cases.


Std. InChiInChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
Avg. Mass240.2557 Da
Molecular Weight240.2557
Monoisotopic Mass240.111008 Da
Nominal Mass240
ChemSpider ID95083

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Dose Chart


Duration Chart

DON Duration Data
Onset30-120 minutes
Duration14-22 hours
After-effects12-24 hours



  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O



  1. abcr AB259466
  2. Advanced Technology & Industrial 3573165
  3. AK Scientific 8525AJ
  4. AKos AKOS024457908
  5. Alfa Chemistry 51481-10-8
  6. Ambeed A411475
  7. ApexBio B7557
  8. Apollo Scientific Limited BID1001
  9. Apollo Scientific Limited BIMS109
  10. Ark Pharm, Inc. AK326173
  11. Aurora Fine Chemicals K02.108.873
  12. Bide Pharmatech BD123774
  13. BLDpharm BD123774
  14. BOC Sciences 51481-10-8
  15. CambridgeSoft Corporation 10242
  16. ChEMBL CHEMBL513300
  17. ChemIDplus 051481108
  18. ChemScene 51481-10-8
  19. CSDeposition Service BID1001
  20. DiscoveryGate 40024
  21. DSigDB d4ctd_341
  22. eMolecules 474371
  23. EPA DSSTox 398_CPDBAS_v5b
  24. EPA DSSTox DTXCID50382
  27. Glentham Life Sciences GP1680
  28. Jean-Claude Bradley Open Melting Point Dataset 22639
  29. LabNetwork LN01267845
  30. Laboratory Chemical Safety Summary 40024
  31. Labseeker SC-94746
  32. LeadScope LS-157038
  33. LGC Standards DRE-A12147000AL-100
  34. LGC Standards DRE-C12147000
  35. LGC Standards DRE-C12147000-10MG
  36. LGC Standards DRE-C12147000-5MG
  37. LGC Standards DRE-V12147000AL-100
  38. MassBank AC000110
  39. MassBank AC000111
  40. MassBank AC000112
  41. MassBank AC000113
  42. MassBank AC000114
  43. Mcule MCULE-5992308149
  44. Molport MolPort-003-925-048
  45. Molport MolPort-046-588-673
  46. MuseChem R058378
  47. PDB 3J6
  48. Phion 69480201
  49. PubChem 40024
  50. Royal Society of Chemistry b711352h
  51. Ryan Scientific 107-58375
  52. Santa Cruz Biotechnology sc-204711
  53. Sigma-Aldrich 32943
  54. Sigma-Aldrich 34124
  55. Sigma-Aldrich 46911
  56. Sigma-Aldrich CRM46911
  57. Sigma-Aldrich D0156
  58. Sigma-Aldrich IRMM315
  59. Sigma-Aldrich SIAL-32943
  60. Sigma-Aldrich SIAL-34124
  61. Sigma-Aldrich SIAL-IRMM315
  62. Sigma-Aldrich SIGMA-D0156
  63. Sigma-Aldrich SUPELCO-46911
  64. Sigma-Aldrich SUPELCO-CRM46911
  65. Springer Nature
  66. Springer Nature
  67. Springer Nature A case report on a minor contamination of nivalenol in cereals harvested in Canada
  68. Springer Nature A Comparison of Chromatographic Methods for the Determination of Deoxynivalenol in Wheat
  69. Springer Nature A novel actinomycete derived from wheat heads degrades deoxynivalenol in the grain of wheat and barley affected by Fusarium head blight
  70. Springer Nature Aerobic and anaerobic de-epoxydation of mycotoxin deoxynivalenol by bacteria originating from agricultural soil
  71. Springer Nature Analysis and occurrence of deoxynivalenol (DON) in cocoa
  72. Springer Nature Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives
  73. Springer Nature Blood plasma levels of deoxynivalenol and its de-epoxy metabolite in broilers after a single oral dose of the toxin
  74. Springer Nature Carry-over of deoxynivalenol into eggs of laying hens u2014 Preliminary results
  75. Springer Nature Chronic ingestion of deoxynivalenol at human dietary levels impairs intestinal homeostasis and gut microbiota in mice
  76. Springer Nature Conjugation of deoxynivalenol by Alternaria alternata (54028 NRRL), Rhizopus microsporus var. rhizopodiformis (54029 NRRL) and Aspergillus oryzae (5509 NRRL)
  77. Springer Nature Critical evaluation of indirect methods for the determination of deoxynivalenol and its conjugated forms in cereals
  78. Springer Nature Decontamination ofFusarium mycotoxins, nivalenol, deoxynivalenol, and zearalenone, in barley by the polishing process
  79. Springer Nature Deoxynivalenol and 15-monoacetyl deoxynivalenol production by Fusarium graminearum R6576 in liquid media
  80. Springer Nature Deoxynivalenol and its metabolite deepoxy-deoxynivalenol: multi-parameter analysis for the evaluation of cytotoxicity and cellular effects
  81. Springer Nature Deoxynivalenol impair skin barrier function through the down regulation of filaggrin and claudin 1/8 in HaCaT keratinocyte
  82. Springer Nature Deoxynivalenol resistance as a component of FHB resistance
  83. Springer Nature Deoxynivalenol, zearalenone, and Fusarium graminearum contamination of cereal straw; field distribution; and sampling of big bales
  84. Springer Nature Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance
  85. Springer Nature Deoxynivalenol: signaling pathways and human exposure risk assessment?an update
  86. Springer Nature Detection of Deoxynivalenol Using Fluorescence Excitationu2013Emission Matrix
  87. Springer Nature Determination of Deoxynivalenol in Medicinal Herbs and Related Products by GCu2013ECD and Confirmation by GCu2013MS
  88. Springer Nature Determination of Deoxynivalenol in Wheat Bran and Whole-Wheat Flour by Fluorescence Polarization Immunoassay
  89. Springer Nature Development of a Novel Immunoaffinity Column for the Determination of Deoxynivalenol and Its Acetylated Derivatives in Cereals
  90. Springer Nature Dietary deoxynivalenol does not affect mineral element accumulation in breast and thigh muscles of broiler chicken
  91. Springer Nature Direct quantification of deoxynivalenol glucuronide in human urine as biomarker of exposure to the Fusarium mycotoxin deoxynivalenol
  92. Springer Nature Disappearance of deoxynivalenol from digesta progressing along the chicken's gastrointestinal tract after intubation with feed containing contaminated corn
  93. Springer Nature Distinct Distribution of Deoxynivalenol, Nivalenol, and Ergosterol in Fusarium-infected Japanese Soft Red Winter Wheat Milling Fractions
  94. Springer Nature Effect of a combination of deoxynivalenol and nivalenol on lipopolisaccharide-induced nitric oxide production by mouse macrophages
  95. Springer Nature Effect of deoxynivalenol (DON) on growing pigs and its modification by modified yeast cell wall or modified yeast cell wall and bentonite
  96. Springer Nature Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line
  97. Springer Nature Effects of deoxynivalenol (DON) and related compounds on bovine peripheral blood mononuclear cells (PBMC) in vitro and in vivo
  98. Springer Nature Effects of deoxynivalenol (DON) in the lactation diet on the feed intake and fertility of sows
  99. Springer Nature Effects of deoxynivalenol (DON) on growth performance, nutrient digestibility and DON metabolism in pigs
  100. Springer Nature Effects of deoxynivalenol and lipopolysaccharide on electrophysiological parameters in growing pigs
  101. Springer Nature Effects of deoxynivalenol in naturally contaminated wheat on feed intake and health status of horses
  102. Springer Nature Effects of feeding deoxynivalenol (DON)-contaminated wheat to laying hens and roosters of different genetic background on the reproductive performance and health of the newly hatched chicks
  103. Springer Nature Effects of increasing concentrations of sodium metabisulphite (Na2S2O5, SBS) on deoxynivalenol (DON) concentration and microbial spoilage of triticale kernels preserved without and with propionic acid at various moisture contents
  104. Springer Nature Effects of low to moderate levels of deoxynivalenol on feed and water intake, weight gain, and slaughtering traits of broiler chickens
  105. Springer Nature Effects of oral deoxynivalenol exposure on immune-related parameters in lymphoid organs and serum of mice vaccinated with porcine parvovirus vaccine
  106. Springer Nature Effects of the thermal environment on metabolism of deoxynivalenol and thermoregulatory response of sheep fed on corn silage grown at enriched atmospheric carbon dioxide and drought
  107. Springer Nature Enzyme-linked immunosorbent assay in analysis of deoxynivalenol: investigation of the impact of sample matrix on results accuracy
  108. Springer Nature Expression of immune relevant genes in pigs under the influence of low doses of deoxynivalenol (DON)
  109. Springer Nature Fluctuation in the ergosterol and deoxynivalenol content in barley and malt during malting process
  110. Springer Nature Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs
  111. Springer Nature Hematologic and immunologic toxicity of deoxynivalenol (DON)-contaminated diets to growing chickens
  112. Springer Nature Humic substances failed to prevent the systemic absorption of deoxynivalenol (DON) and its adverse effects on piglets
  113. Springer Nature Hydrothermal treatment of naturally contaminated maize in the presence of sodium metabisulfite, methylamine and calcium hydroxide; effects on the concentration of zearalenone and deoxynivalenol
  114. Springer Nature Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health
  115. Springer Nature In vivo contribution of deoxynivalenol-3-??-d-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics
  116. Springer Nature Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects
  117. Springer Nature Induction of MAPK-dependent transcription factors by deoxynivalenol in human cell lines
  118. Springer Nature Influence of nitrogen fertilization on deoxynivalenol contamination of winter wheat u2014 experimental field trials and evaluation of analytical methods
  119. Springer Nature Intestinal toxicity of deoxynivalenol is limited by Lactobacillus rhamnosus RC007 in pig jejunum explants
  120. Springer Nature Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-??-d-glucoside
  121. Springer Nature Lipopolysaccharides (LPS) modulate the metabolism of deoxynivalenol (DON) in the pig
  122. Springer Nature Method of analysis for deoxynivalenol and zearalenone from cereal grains
  123. Springer Nature Microbial biotransformation of DON: molecular basis for reduced toxicity
  124. Springer Nature Modelling within-field variations in deoxynivalenol (DON) content in oats using proximal and remote sensing
  125. Springer Nature Modified use of a commercial ELISA kit for deoxynivalenol determination in rice and corn silage
  126. Springer Nature Molecular cloning and characterization of an up-regulated UDP-glucosyltransferase gene induced by DON from Triticum aestivum L. cv. Wangshuibai
  127. Springer Nature Mycotoxin binder improves growth rate in piglets associated with reduction of toll-like receptor-4 and increase of tight junction protein gene expression in gut mucosa
  128. Springer Nature Mycotoxins in cereal grain (part 15). Distribution of deoxynivalenol in naturally contaminated wheat kernels
  129. Springer Nature Natural occurrence of deoxynivalenol, 3-acetyl-deoxynivalenol, 15-acetyl-deoxynivalenol, nivalenol, 4,7-dideoxynivalenol, and zearalenone in polish wheat
  130. Springer Nature Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-epi-deoxynivalenol
  131. Springer Nature null
  132. Springer Nature Occurrence of deoxynivalenol (DON) and ochratoxin A (OTA) in dog foods
  133. Springer Nature Occurrence of Fusarium head blight (FHB) in southern NSW in 2000: identification of causal fungi and determination of putative chemotype of Fusarium graminearum isolates by PCR
  134. Springer Nature On the effects of the Fusarium toxin deoxynivalenol (DON) administered per os or intraperitoneal infusion to sows during days 63 to 70 of gestation
  135. Springer Nature On the effects ofFusarium-contaminated wheat and the feed intake level on ruminal fermentation and toxin-turnover of cows
  136. Springer Nature Optical waveguide lightmode spectroscopy techniqueu2013based immunosensor development for deoxynivalenol determination in wheat samples
  137. Springer Nature Prediction of deoxynivalenol toxicokinetics in humans by in vitro-to-in vivo extrapolation and allometric scaling of in vivo animal data
  138. Springer Nature Protective Effect of Saccharomyces boulardii on Deoxynivalenol-Induced Injury of Porcine Macrophage via Attenuating p38 MAPK Signal Pathway
  139. Springer Nature Protective Role of Selenium in Immune-Relevant Cytokine and Immunoglobulin Production by Piglet Splenic Lymphocytes Exposed to Deoxynivalenol
  140. Springer Nature Quantitative Determination of Deoxynivalenol (DON) Using the Amplified Luminescent Proximity Homogeneous Assay (AlphaLISA)
  141. Springer Nature Reduction of Deoxynivalenol in Barley by Treatment with Aqueous Sodium Carbonate and Heat
  142. Springer Nature Research note: Effects of deoxynivalenol on immunohistological parameters in pigs
  143. Springer Nature Sample clean-up methods, immunoaffinity chromatography and solid phase extraction, for determination of deoxynivalenol and deepoxy deoxynivalenol in swine serum
  144. Springer Nature Sensitive method for determination of DON in cocoa by means of HPLC-techniques
  145. Springer Nature Serum cation profile of broilers at various stages of exposure to deoxynivalenol
  146. Springer Nature Simultaneous Determination of Deoxynivalenol and Nivalenol in Traditional Chinese Medicine by SPE and LC
  147. Springer Nature Simultaneous Determination of Deoxynivalenol, Deoxynivalenol-3-Glucoside and Nivalenol in Wheat Grains by HPLC-PDA with Immunoaffinity Column Cleanup
  148. Springer Nature Simultaneous determination of the levels of deoxynivalenol, 3-acetyldeoxynivalenol, and nivalenol in grain and feed samples from South Korea using a high-performance liquid chromatographyu2013photodiode array detector
  149. Springer Nature Stability of citrinin and deoxynivalenol during germination process of barley
  150. Springer Nature Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat
  151. Springer Nature The feed contaminant deoxynivalenol affects the intestinal barrier permeability through inhibition of protein synthesis
  152. Springer Nature The influence of the mycotoxin deoxynivalenol on jejunal glucose transport in pigs
  153. Springer Nature Thioredoxin-1 contributes to protection against DON-induced oxidative damage in HepG2 cells
  154. Springer Nature Using near-isogenic barley lines to validate deoxynivalenol (DON) QTL previously identified through association analysis
  155. Springer Nature Validation of an HPLC Analytical Method Coupled to a Multifunctional Clean-up Column for the Determination of Deoxynivalenol
  156. Thomson Pharma 00479623
  157. Tocris Bioscience 3976
  158. TripleBond CD0228
  159. VulcanChem VC281343
  160. Wikidata Q420518
  161. Wikipedia Vomitoxin

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  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

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