Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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DOM Also known as:

  • (R)-2,5-Dimethoxy-4-methylamphetamine
  • (2R)-1-(2,5-Dimethoxy-4-methylphenyl)-2-propanamin[German][ACD/IUPAC Name]
  • (2R)-1-(2,5-Dimethoxy-4-methylphenyl)-2-propanamine[ACD/IUPAC Name]
  • (2R)-1-(2,5-Diméthoxy-4-méthylphényl)-2-propanamine[French][ACD/IUPAC Name]
  • (2R)-1-(2,5-dimethoxy-4-methylphenyl)propan-2-amine
  • (R)-2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine
  • 2-(2,5-Dimethoxy-4-methyl-phenyl)-1-methyl-ethylamine
  • Benzeneethanamine, 2,5-dimethoxy-α,4-dimethyl-, (αR)-[ACD/Index Name]
  • DOM[Formula]
  • LX3MC6OB9X
  • STP[Formula]
  • (-)-1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane
  • (2R)-1-(2,5-dimethoxy-4-methyl-phenyl)propan-2-amine
  • [(1R)-2-(2,5-dimethoxy-4-methyl-phenyl)-1-methyl-ethyl]amine
  • PDSP2_000453
  • r-2,5-dimethoxy-4-methylamphetamine

The most popular psychedelic amphetamine due to its pleasant effects, lower potency and shorter duration. Effects have been described as ‘sillier’ than LSD and related DOX chemicals


DOM is a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic and stimulant effects. It produces its effects by acting on serotonin receptors in the brain. DOM was first synthesized and tested in 1963 by Alexander Shulgin.

It attained some popularity during the summer of 1967 under the name “STP” (“Serenity, Tranquility, and Peace”), but its use was short-lived due to its side effects. In 1991, the synthesis and pharmacology of DOM was published in Shulgin’s book PiHKAL (“Phenethylamines I Have Known And Loved”). .

Over the years, DOM has gained a reputation for being a highly dose-sensitive psychedelic that is often sold on blotting paper and known for its strong visuals, body load and neutral, analytical headspace. Many reports also indicate that the effects of this chemical may be overly difficult to use for those who are not already experienced with psychedelics.


DOM is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. In mid-1967, tablets containing 20 mg (later 10 mg) of DOM were widely distributed in the Haight-Ashbury District of San Francisco under the name of "STP" (short for "Serenity, Tranquility, and Peace"). This short-lived appearance of DOM on the black market proved disastrous for several reasons.

First, the tablets contained an excessively high dose of the chemical. This, combined with DOM’s slow onset of action (which encouraged some users, familiar with substances that have quicker onsets, such as LSD, to re-dose) and its remarkably long duration, caused many users to panic and sent some to the emergency room. Second, treatment of such overdoses was complicated by the fact that it was unknown at the time that the tablets called “STP” were DOM.


Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα.

DOM contains methoxy functional groups (OCH3) attached to carbons R2 and R5 and a methyl group attached to carbon R4 of the phenyl ring. DOM is the amphetamine analogue of the phenethylamine 2C-D.

Common Name(R)-2,5-Dimethoxy-4-methylamphetamine
Systematic name(R)-2,5-Dimethoxy-4-methylamphetamine
Std. InChiInChI=1S/C12H19NO2/c1-8-5-12(15-4)10(6-9(2)13)7-11(8)14-3/h5,7,9H,6,13H2,1-4H3
Avg. Mass209.2848 Da
Molecular Weight209.2848
Monoisotopic Mass209.141586 Da
Nominal Mass209
ChemSpider ID9910656

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Dose Chart


Duration Chart

DOM Duration Data
Onset2-4 hours
Duration8-30 hours
After-effects12-24 hours



  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

Legal Status

Internationally, mescaline is part of the the Convention on Psychotropic Substances of 1971 as a Schedule I substance.

  • Australia: Australia has a blanket ban over all substituted phenethylamines including the entire DOx family.
  • Austria: DOM is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344 as "STP".
  • Belgium: DOM is a Schedule I drug.
  • Canada: DOM is a Schedule I drug.
  • Germany: DOM is controlled under Anlage I BtMG (Narcotics Act, Schedule I), former: Opiumgesetz (Opium Act) as of April 15, 1971. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Latvia: DOM is a Schedule I controlled substance.
  • New Zealand: DOM is a Class A drug.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: DOM is a Class A drug.
  • United States: DOM is a Schedule I drug.
  • Germany: DOM is controlled under BtMG Anlage I, making it illegal to manufacture, import, possess, sell, or transfer it without a license.
  • Sources


    1. Shulgin, Alexander (1991). PiHKAL: A Chemical Love Story. Berkeley, CA: Transform Press. pp. 53–56.
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    7. Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
    8. "CONVENTION ON PSYCHOTROPIC SUBSTANCES 1971" (PDF). United Nations. Retrieved December 10, 2019.
    9. New Psychoactive Substances (National Drug and Alcohol Research Centre 2014) | Psychoactive Substances.pdf
    11. Controlled Drugs and Substances Act, Statutes of Canada (1996), c. C-19). Item 19.3. [1]
    12. "Fünfte Verordnung über die den Betäubungsmitteln gleichgestellten Stoffe" (in German). Bundesanzeiger Verlag. Retrieved December 11, 2019.
    13. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
    14. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 11, 2019.
    15. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) |


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