Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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DOB Also known as:

  • 2,5-Dimethoxy-4-bromoamphetamine[Wiki]
  • (±)-1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • (±)-1-(4-Bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-4-Bromo-2,5-dimethoxy-α-methylphenethylamine
  • 1-(4-Brom-2,5-dimethoxyphenyl)-2-propanamin[German][ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-dimethoxyphenyl)-2-propanamine[ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-diméthoxyphényl)-2-propanamine[French][ACD/IUPAC Name]
  • 1-(4-Bromo-2,5-dimethoxyphenyl)propan-2-amine
  • 4-Bromo-2,5-dimethoxy-amphetamine
  • 5874
  • Benzeneethanamine, 4-bromo-2,5-dimethoxy-α-methyl-[ACD/Index Name]
  • Benzeneethanamine, 4-bromo-2,5-dimethoxy-α-methyl-, (±)-
  • brolamfétamine[French][INN]
  • Brolamfetaminum[Latin][INN]
  • brolamphetamine
  • brolanfetamina[Spanish][INN]
  • dl-2,5-Dimethoxy-4-bromoamphetamine
  • броламфетамин[Russian][INN]
  • برولامفيتامين[Arabic][INN]
  • 布苯丙胺[Chinese][INN]
  • (±)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • (±)-2,5-Dimethoxy-4-bromoamphetamine
  • (±)-4-Bromo-2,5-dimethoxy-α-methylphenethylamine
  • [3H](+)DOB
  • 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane
  • 2-(2-Methoxy-Phenyl)-1-Methyl-Ethylamine
  • 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine
  • 2-(5-Bromo-2,4-dimethoxy-phenyl)-1-methyl-ethylamine
  • 2,5-dimethoxy-(4-bromo)phenylisopropylamine
  • 2,5-dimethoxy-4-bromoamphetamine|DOB
  • 4-Bromo-2,5-dimethoxy-a-methylbenzeneethanamine
  • 4-Bromo-2,5-dimethoxyamphetamine
  • 4-bromo-2,5-dimethoxyphenylisopropylamine
  • 4-bromo-2,5-dimethoxyphenylisopropylaminerolamfetamine
  • 4-bromo-2,5-dimethoxy-α-methylbenzeneethanamine
  • 4-Bromo-DMA
  • Benzeneethanamine,4-bromo-2,5-dimethoxy-α-methyl-(±)-
  • DOB
  • DOB-4

DOB is a relatively uncommon synthetic psychedelic. It is best known for its very low doses and long duration. Historically it has rarely been taken deliberately, but in place of LSD, however it has recently found its own place in the research chemical scene.


It is a member of the DOx family of psychedelic amphetamines. While DOB had first been synthesized in 1967 and briefly tested in 1971, it took until the 1991 publication of the book PiHKAL ("Phenethylamines I Have Known And Loved") by Alexander Shulgin to be documented in-depth. Today, DOB is used as a recreational drug and an entheogen.

It is still rarely sold online but is more commonly found in the streets the form of misrepresented LSD due to its ability to fit onto similar-sized blotter paper. Very little data exists about the pharmacological properties, metabolism, and toxicity of DOB in humans. Along with its sensitive dose-response, unusually long and unpredictable duration, many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with using hallucinogens.

It is highly advised to use harm reduction practices if using this substance.




Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα.

DOB contains methoxy functional groups OCH3 attached to carbons R2 and R5 as well as a bromine atom attached to carbon R4 of the phenyl ring.

DOB is the amphetamine analogue of the phenethylamine 2C-B.

Common Name2,5-Dimethoxy-4-bromoamphetamine
Systematic name2,5-Dimethoxy-4-bromoamphetamine
Std. InChiInChI=1S/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)
Avg. Mass274.1542 Da
Molecular Weight274.1542
Monoisotopic Mass273.036438 Da
Nominal Mass273
ChemSpider ID55902

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Dose Chart


Duration Chart

DOB Duration Data
Onset30-120 minutes
Duration8-24 hours
After-effects2-12 hours



  1. Mescaline
  2. NBOMes
  3. 2C-x
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. MXE
    • As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
  8. MDMA
    • The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
  9. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
  10. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. DXM
    • The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
  2. PCP
    • Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
  3. Amphetamines
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  4. Cocaine
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
  5. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Low Synergy

  1. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Opioids
    • No unexpected interactions.

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
    • Ketamine and psychedelics tend to potentiate each other - go slowly.
  5. N2O

Auditory Effects

Psychological Effects

The head space of DOB is described by many as one of prominent mental stimulation and a powerful enhancement of a person's current mental state. Many users report that it may not be as deep as other traditional psychedelics such as LSD or psilocin and that it is comparatively empty regarding its insightfulness.

Pharmacological Effects

DOB’s psychedelic effects are believed to come from its efficacy at the 5-HT2 receptor family as a partial agonist. DOB appears to be quite selective for the 5-HT2B receptor and is often used in scientific research when studying the 5-HT2 receptor subfamily. It has been suggested that DOB is a prodrug metabolized in the lungs. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Physical Effects

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring but seems only to be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Visual Effects




DOB visual geometry can be described as more similar in appearance to that of LSD, 25I-NBOMe or 2C-B than that of mescaline, psilocin or DMT. It can be comprehensively described through its variations as intricate in complexity, algorithmic in form, synthetic in feel, brightly lit, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in its corners, non-immersive in-depth and consistent in intensity. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory states

DOB and other substituted amphetamines produce a full range of high-level hallucinatory states in a fashion that is more or less consistent and reproducible than that of many other commonly used psychedelics. These effects include:

Legal Status

Internationally, DOB is a Schedule I drug under the Convention on Psychotropic Substances.

  • Australia: DOB is listed as a Schedule II substance in Australia.
  • Austria: DOB is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Canada: DOB is listed as a Schedule 1 as it is an analogue of amphetamine.
  • Germany: DOB is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of September 1, 1984. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Latvia: DOB is a Schedule I controlled substance.
  • New Zealand: DOB is Schedule I (Class A) in New Zealand. DOB would also qualify as an analogue under New Zealand's catch-all analogues section in Schedule 3 / Class C of their drug laws which would make 2C-I, 2C-E, DOI, DOB, ephedrine, and pseudoephedrine Schedule 3 compounds in the country.
  • Poland: DOB is controlled in Poland.
  • Switzerland: DOB is illegal in Switzerland.
  • United Kingdom: DOB is Schedule I/Class A in the U.K., making it illegal to sell, buy, or possess without a license.
  • United States: DOB is Schedule I in the U.S., making it illegal to sell, buy, gift, produce or possess without a DEA license.
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    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.