Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.
This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.
Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.
DMT Also known as:
ine, N,N-dimethyl-[ACD/Index Name]
,N-dimethylethanami[ACD/IUPAC Name] ne
,N-diméthyléthanami[French][ACD/IUPAC Name] ne
- Indole, 3-(2-(dimet
- Indole, 3-[2- (dime
- Indole, 3-[2-(dimet
- MFCD00055989[MDL number]
- tryptamine, dimethy
- 3-[2- (Dimethylamin
- 5-22-10-00048 (Beil
stein Handbook Refe[Beilstein] rence)
- N N-DIMETHYL-1H-IND
- WLN: T56 BMJ D2N1&1
A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short ‘breakthrough’ experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).
Despite being one of the simplest psychedelic compounds, it is known for its unique ability to produce short-lived but intense visionary states and complete hallucinations. It is thought to produce its psychedelic effects by binding to serotonin receptors in the brain, although the precise mechanism is not fully understood. DMT is present in over 65 species of plants and has been identified as being a normal constituent of human metabolism and an endogenous neurotransmitter in certain rodents.
Its presence is also known to be widespread throughout the plant kingdom. Although various theories have been postulated, its neurobiological function has yet to be determined. Depending on the dosage and method of administration, the effects of DMT can range from mild psychedelic states to powerfully immersive life-altering experiences which are often described as the ultimate displacement from ordinary consciousness in which users report experiencing ineffable spiritual realms or alternate dimensions.
When vaporized or smoked, DMT produces short-lived effects with a very rapid onset that is sometimes described as an “inconceivably high-speed rollercoaster ride. " When ingested in combination with a MAOI or RIMA agent, it becomes active orally and significantly longer lasting, immersive, and interactive in nature: this combination is known as ayahuasca. Ayahuasca brews have been used traditionally in South America since at least around the year 1500.
Unlike most highly prohibited substances, DMT is not considered to be addictive or toxic by the scientific community. Nevertheless, unpredictable adverse reactions such as uncontrollable anxiety, delusions and psychosis can always occur, particularly among those predisposed to mental disorders. While these negative reactions or “bad trips” can often be attributed to user inexperience or improper preparation of set and setting, they have been known to happen spontaneously among even highly experienced users as well.
It is therefore highly advised to use harm reduction practices if using this substance.
In 1955, a team of American chemists led by Evan Horning isolated and formally identified DMT in the seeds and pods of Anadenanthera peregrina. Since 1955, DMT has been found in a host of organisms: in at least fifty plant species belonging to ten families, and in at least four animal species, including one gorgonian and three mammalian species.
Tryptamines share a core structure consisting of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain.
DMT contains two methyl groups (CH3-) bound to the terminal amine RN at the end of this chain. DMT has many homologs and analogs from base tryptamines like MET and DPT, to four and five position substituted variants such as 4-PO-DMT (psilocybin), 4-AcO-DMT (psilacetin), 5-HO-DMT (bufotenin), and 5-MeO-DMT. DMT is a white, pungent-smelling, crystalline solid.
It is insoluble in water, but soluble in organic solvents and aqueous acids.
|Avg. Mass||188.2688 Da|
|Monoisotopic Mass||188.131348 Da|
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- Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
- Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Internationally, DMT is classified as a Schedule I controlled substance under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in DMT is supposed to be closely monitored and its use is supposed to be restricted to scientific research and medical use. Natural materials containing DMT, including ayahuasca, are not regulated under the 1971 Psychotropic Convention.
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