Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

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4-FPP Also known as:

  • 1-(4-Fluorophenyl)piperazine[ACD/IUPAC Name]
  • 1-(4-Fluorophényl)pipérazine[French][ACD/IUPAC Name]
  • 1-(4-Fluorphenyl)piperazin[German][ACD/IUPAC Name]
  • 1-(p-Fluorophenyl)piperazine
  • 4-fluoro-phenylpiperazine
  • 4-Fluorophenylpiperazine
  • 4-FPP
  • Flipiperazine
  • Fluoperazine
  • para-Fluorophenylpiperazine[Wiki]
  • pFPP
  • Piperazine, 1-(4-fluorophenyl)-[ACD/Index Name]
  • VML61BE244
  • (4-fluorophenyl)piperazine
  • 1-​(4-​fluorophenyl)​piperazine
  • 1-(4-Fluorobenzyl)piperazine (en)
  • 1-(4'-fluorophenyl)piperazine
  • 1-(4-Fluorophenyl)-piperazine
  • 1-(4-Fluoro-phenyl)-piperazine
  • 1-(4-fluorophenyl)piperazine, 98%
  • 4-(1-Piperazino)fluorobenzene
  • 4-(1-Piperazinyl)fluorobenzene
  • c10h13fn2
  • MFCD00041163[MDL number]
  • N-(4-Fluorophenyl)piperazine
  • N-(p-Fluorophenyl)piperazine
  • p-fluorophenyl piperazine[ACD/IUPAC Name]
  • UNII:VML61BE244

A piperazine derivative that has been reported to have mild pyschedelic effects, and also empathogen qualities. It has been sold in many branded legal highs.


Common Namepara-Fluorophenylpiperazine
Systematic namepara-Fluorophenylpiperazine
Std. InChiInChI=1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
Avg. Mass180.222 Da
Molecular Weight180.222
Monoisotopic Mass180.106277 Da
Nominal Mass180
ChemSpider ID67803

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Dose Chart


Duration Chart

4-FPP Duration Data
Onset15-45 minutes
Duration4-8 hours



  1. Mushrooms
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  2. LSD
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  3. DMT
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  4. Mescaline
    • The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
  5. 2C-x
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  6. Cannabis
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  7. Ketamine
    • No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
  8. MXE
    • Risk of tachycardia, hypertension, and manic states
  9. Cocaine
    • This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
  10. Caffeine
    • This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
  11. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
  12. GHB/GBL
    • Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  13. Opioids
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


  1. DOx
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  2. NBOMes
    • Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
  3. 2C-T-x
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
  4. 5-MeO-xxT
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
  5. DXM
    • Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
  6. PCP
    • This combination can easily lead to hypermanic states

Low Synergy

  1. Benzodiazepines
    • Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction

No Synergy

  1. SSRIs

High Synergy

  1. N2O
  2. MDMA
    • Amphetamines increase the neurotoxic effects of MDMA



  1. 1717 CheMall HE001855
  2. 1717 CheMall HE237606
  3. A&J Pharmtech AJ-10186
  4. A&J Pharmtech AJ-145423
  5. ABI Chemicals AC1Q4MAJ
  6. ABI Chemicals AC1Q4NTP
  7. ABI Chemicals AC2A00BU8
  8. Accel Pharmtech FB2693
  9. AChemo
  10. ACT Chemical ACT03624
  11. Advanced Technology & Industrial 1082077
  12. Advanced Technology & Industrial 3561221
  13. AK Scientific W4628
  14. AKos AKOS000101161
  15. AldLab Chemicals
  16. Alfa Aesar A14541
  17. Alfa Chemistry ACM2252633
  18. Alfa Chemistry ACM2252633
  19. Alichem A139004076
  20. Alinda Chemical ALBB-005983
  21. ALK ALG00006641
  22. Amadis Chemical A4824
  23. American Custom Chemicals Corp HCH0015223
  24. Angene AG-E-64301
  25. Angene AGN-PC-0JLP8P
  26. Anward ANW-24905
  27. Ark Pharm, Inc. AK-47318
  28. Atomole Scientific AT-19547
  29. Aurora Fine Chemicals A00.560.621
  30. Aurora Fine Chemicals K02.109.101
  31. AZEPINE AZ0001-0207
  32. BePharm 1-(4-Fluorophenyl)piperazine
  33. BePharm B0186
  34. BGS International BG00602025
  35. BGS International BG04482021
  36. Biosynth Carbosynth FF23479
  37. BOC Sciences 2252-63-3
  38. Capot Chemical 8575
  39. Catalysts and Catalysed Reactions CCR0610011755
  40. ChEMBL CHEMBL1184236
  41. Chembo Pharma KB-290679
  42. ChemDB 3963657
  43. ChemDB 4260202
  44. Chemenu CM112493
  45. ChemIDplus 002252633
  46. ChemIDplus 2252633
  47. Chemspace CSC000209892
  48. Collaborative Drug Discovery 945070
  49. Debyesci DB-024588
  50. DiscoveryGate 75260
  51. DTP/NCI 149515
  52. eMolecules 486784
  53. Enamine EN300-33937
  54. eNovation Chemicals D397842
  55. EPA DSSTox DTXCID4099530
  56. FDA UNII - NLM VML61BE244
  57. Finetech Industry FT-0605725
  58. Fluorochem 009784
  59. Fluorochem 181083
  60. Glentham Life Sciences GK3967
  61. GuiChem GZ016032
  62. iChemical EBD967040
  63. J&K Scientific 233682
  64. Jalor-Chem I13-0130
  65. Jean-Claude Bradley Open Melting Point Dataset 23879
  66. Jean-Claude Bradley Open Melting Point Dataset 808
  67. King Scientific KSC00054H
  68. King Scientific KSC494K1N
  69. LabNetwork LN00141453
  70. Laboratory Chemical Safety Summary 75260
  71. Labseeker SC-02608
  72. Life Chemicals F2190-0349
  73. Manchester Organics F26620
  74. Matrix Scientific 037455
  75. Mcule MCULE-8509877241
  76. Molport MolPort-000-003-879
  77. MuseChem R051469
  78. Nature Chemistry nchem.2529-comp3c
  79. NIST Chemistry WebBook 3685659017
  80. NIST Spectra mainlib_343359
  81. NIST Spectra replib_107838
  82. NIST Spectra replib_239039
  83. NIST Spectra replib_379151
  84. NMRShiftDB 20209348
  85. ONSChallenge ONS-mp:1-(4-fluorophenyl)piperazine
  86. Otava Chemicals 1047717.0
  87. Otava Chemicals 3360
  88. OXchem
  89. OXchem AX8000186
  90. Paragos 500062
  91. Parchem – fine & specialty chemicals 35422
  92. Phion 81572423
  93. PubChem 75260
  94. PubMed 2853885
  95. PubMed 6460945
  96. PubMed 9703461
  97. R&D Chemicals 1045-005
  98. Rosewachem RW054570
  99. Rostar Global RS-0248152
  100. Royal Society of Chemistry C8MD00237A
  101. Ryan Scientific 048-11952
  102. Sigma-Aldrich 191337
  103. Sigma-Aldrich ALDRICH-191337
  104. SORD SST0023057
  105. Springer Nature
  106. Springer Nature Synthesis and biological evaluation of new Mannich and Schiff bases containing 1,2,4-triazole and 1,3,4-oxadiazole nucleus
  107. SynQuest 22297
  108. SynQuest 3H32-3-W2
  109. Thieme Chemistry SD-208-00069
  110. Thomson Pharma 00514905
  111. Tractus Company Limited TR-010603
  112. Tractus Company Limited TRA0042243
  113. Vitas-M STK397535
  114. VulcanChem VC240747
  115. Watson International Ltd WIL00734
  116. Wikidata Q7133614
  117. Wikipedia Para-Fluorophenylpiperazine
  118. Wikipedia PFPP
  119. Wonderchem WD0330Y
  120. ZINC ZINC00066094

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.