Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.

Experimental drugs have extremely limited human consumption data. There is not enough reliable information about this substance. This is most likely because the substance is is not very old. Information on these substances is limite and incomplete. Please be cautioned. Always practice harm reduction.

Disclaimer: Psychedelic drugs offer some of the most power and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

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Practice Harm Reduction. Proceed with Caution.



Also known as:

  • 1-(4-Fluorophenyl)piperazine[ACD/IUPAC Name]
  • 1-(4-Fluorophényl)pipérazine[French][ACD/IUPAC Name]
  • 1-(4-Fluorphenyl)piperazin[German][ACD/IUPAC Name]
  • 1-(p-Fluorophenyl)piperazine
  • 4-fluoro-phenylpiperazine
  • 4-Fluorophenylpiperazine
  • 4-FPP
  • Flipiperazine
  • Fluoperazine
  • para-Fluorophenylpiperazine[Wiki]
  • pFPP
  • Piperazine, 1-(4-fluorophenyl)-[ACD/Index Name]
  • VML61BE244
  • (4-fluorophenyl)piperazine
  • 1-​(4-​fluorophenyl)​piperazine
  • 1-(4-Fluorobenzyl)piperazine (en)
  • 1-(4'-fluorophenyl)piperazine
  • 1-(4-Fluorophenyl)-piperazine
  • 1-(4-Fluoro-phenyl)-piperazine
  • 1-(4-fluorophenyl)piperazine, 98%
  • 4-(1-Piperazino)fluorobenzene
  • 4-(1-Piperazinyl)fluorobenzene
  • c10h13fn2
  • MFCD00041163[MDL number]
  • N-(4-Fluorophenyl)piperazine
  • N-(p-Fluorophenyl)piperazine
  • p-fluorophenyl piperazine[ACD/IUPAC Name]
  • UNII:VML61BE244

A piperazine derivative that has been reported to have mild pyschedelic effects, and also empathogen qualities. It has been sold in many branded legal highs.






Common Namepara-Fluorophenylpiperazine
Systematic namepara-Fluorophenylpiperazine
Std. InChiInChI=1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
Avg. Mass180.222 Da
Molecular Weight180.222
Monoisotopic Mass180.106277 Da
Nominal Mass180
ChemSpider ID67803

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Dosing Guide



4-FPP Duration Data
Onset15-45 minutes
Duration4-8 hours

Interactions and Synergies


  1. Mushrooms
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  2. LSD
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  3. DMT
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  4. Mescaline
    • The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
  5. 2C-x
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  6. Cannabis
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  7. Ketamine
    • No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
  8. MXE
    • Risk of tachycardia, hypertension, and manic states
  9. Cocaine
    • This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine
  10. Caffeine
    • This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
  11. Alcohol
    • Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
  12. GHB/GBL
    • Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
  13. Opioids
    • Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.


  1. DOx
    • The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
  2. NBOMes
    • Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
  3. 2C-T-x
    • Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
  4. 5-MeO-xxT
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
  5. DXM
    • Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
  6. PCP
    • This combination can easily lead to hypermanic states

Low Synergy

  1. Benzodiazepines
    • Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction

No Synergy

  1. SSRIs

High Synergy

  1. N2O
  2. MDMA
    • Amphetamines increase the neurotoxic effects of MDMA

General Information

Come up
After Effects
Test Kits
Marguis Test Result
Note 2:
Note 3:


Pharmacological Effects

Subjective Effects

Physical Effects

Psychological Effects

Visual Effects

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status



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    2. 1717 CheMall HE237606
    3. A&J Pharmtech AJ-10186
    4. A&J Pharmtech AJ-145423
    5. ABI Chemicals AC1Q4MAJ
    6. ABI Chemicals AC1Q4NTP
    7. ABI Chemicals AC2A00BU8
    8. Accel Pharmtech FB2693
    9. AChemo
    10. ACT Chemical ACT03624
    11. Advanced Technology & Industrial 1082077
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    20. Alinda Chemical ALBB-005983
    21. ALK ALG00006641
    22. Amadis Chemical A4824
    23. American Custom Chemicals Corp HCH0015223
    24. Angene AG-E-64301
    25. Angene AGN-PC-0JLP8P
    26. Anward ANW-24905
    27. Ark Pharm, Inc. AK-47318
    28. Atomole Scientific AT-19547
    29. Aurora Fine Chemicals A00.560.621
    30. Aurora Fine Chemicals K02.109.101
    31. AZEPINE AZ0001-0207
    32. BePharm 1-(4-Fluorophenyl)piperazine
    33. BePharm B0186
    34. BGS International BG00602025
    35. BGS International BG04482021
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    37. BOC Sciences 2252-63-3
    38. Capot Chemical 8575
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    40. ChEMBL CHEMBL1184236
    41. Chembo Pharma KB-290679
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    43. ChemDB 4260202
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    47. Chemspace CSC000209892
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    54. eNovation Chemicals D397842
    55. EPA DSSTox DTXCID4099530
    56. FDA UNII - NLM VML61BE244
    57. Finetech Industry FT-0605725
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    60. Glentham Life Sciences GK3967
    61. GuiChem GZ016032
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    63. J&K Scientific 233682
    64. Jalor-Chem I13-0130
    65. Jean-Claude Bradley Open Melting Point Dataset 23879
    66. Jean-Claude Bradley Open Melting Point Dataset 808
    67. King Scientific KSC00054H
    68. King Scientific KSC494K1N
    69. LabNetwork LN00141453
    70. Laboratory Chemical Safety Summary 75260
    71. Labseeker SC-02608
    72. Life Chemicals F2190-0349
    73. Manchester Organics F26620
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    80. NIST Spectra mainlib_343359
    81. NIST Spectra replib_107838
    82. NIST Spectra replib_239039
    83. NIST Spectra replib_379151
    84. NMRShiftDB 20209348
    85. ONSChallenge ONS-mp:1-(4-fluorophenyl)piperazine
    86. Otava Chemicals 1047717.0
    87. Otava Chemicals 3360
    88. OXchem
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    98. Rosewachem RW054570
    99. Rostar Global RS-0248152
    100. Royal Society of Chemistry C8MD00237A
    101. Ryan Scientific 048-11952
    102. Sigma-Aldrich 191337
    103. Sigma-Aldrich ALDRICH-191337
    104. SORD SST0023057
    105. Springer Nature
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    107. SynQuest 22297
    108. SynQuest 3H32-3-W2
    109. Thieme Chemistry SD-208-00069
    110. Thomson Pharma 00514905
    111. Tractus Company Limited TR-010603
    112. Tractus Company Limited TRA0042243
    113. Vitas-M STK397535
    114. VulcanChem VC240747
    115. Watson International Ltd WIL00734
    116. Wikidata Q7133614
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    118. Wikipedia PFPP
    119. Wonderchem WD0330Y
    120. ZINC ZINC00066094


    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.