Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.
Psychedelics are drugs which cause profound changes in a one’s perceptions of reality, otherwise known as hallucinations. While under the influence of hallucinogens, users might see images, hear sounds or feel sensations. These chemicals offer some of the most intense psychological experiences and care should be taken when ingesting them.
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Practice Harm Reduction. Proceed with Caution.
Also known as:
- 2,5 Dimethoxy-4-(pr
opylthio) phenethyl amine
(propylsulfanyl)phe[German][ACD/IUPAC Name] nyl]ethanamin
(propylsulfanyl)phe[ACD/IUPAC Name] nyl]ethanamine
(propylsulfanyl)phé[French][ACD/IUPAC Name] nyl]éthanamine
2,5-dimethoxy-4-(pr[ACD/Index Name] opylthio)-
- MFCD03840819[MDL number]
- phenethylamine, 2,5
- phenethylamine, 2,5
A relatively uncommon psychedelic phenethylamine and possible MAOI. Long lasting, an possesses an unpredictable dosage curve. Questionable safety in combination with most things.
2C-T-7 was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. In contrast to other members of the 2C-x family, 2C-T-7 has gained a reputation of being an unpredictable, dose-sensitive psychedelic capable of producing strong visual effects and an intense body load, which can manifest as a dangerous delirium in extreme cases.
Many reports indicate that the physical effects are too severe for inexperienced users or those with pre-existing medical conditions. This particular compound is part of the so-called “magical half-dozen” which refers to Shulgin’s self-rated most important phenethylamine compounds, all of which – with the exception of mescaline – he designed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.
2C-T-7 is also substituted at R4 with a propyl thioether group. 2C-T-7 is analogous to 2C-T-2; the two differ by the length of the alkane chain in their thioether functional group.
|Avg. Mass||255.3763 Da|
|Monoisotopic Mass||255.129303 Da|
Interactions and Synergies
There are no existing interaction or synergy data for this drug.
|Effects||Euphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.|
|Avoid||Do not take if currently taking a MAOI.|
|Risks||There have been several reports of deaths from 2C-T-7, and many reports of severe dissociation and vomiting (a dangerous combination) after both oral and insufflated use.|
|Marguis Test Result|
2C-T-7’s psychedelic effects have been shown to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. With serious adverse effects seen on overdoses of this compound (potentially Serotonin Syndrome) and as the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A inhibitor and many of the amphetamine-analogs of the 2C-T-x series are highly selective MAO-A inhibitors (with ALEPH-7 being one of the most potent), this substance is widely thought to also have MAOI effects.
- Stimulation - In terms of its effects on the physical energy levels of the user, 2C-T-7 is generally considered to be energetic and stimulating in a fashion is comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P. However, at certain doses and contexts, it may produce periods of notable sedation.
- Spontaneous physical sensations - The "body high" of 2C-T-7 is intense, but in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
- Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion, for most users it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
- Changes in felt bodily form
- Tactile enhancement
- Temperature regulation suppression
- Abnormal heartbeat
- Increased blood pressure
- Increased heart rate
- Difficulty urinating or Frequent urination
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Muscle cramps
- Nausea - Mild to extreme nausea is commonly reported when consumed in moderate to high dosages, and either passes once the user has vomited or gradually fades by itself as the peak sets in.
- Stomach bloating
- Stomach cramps
- Teeth grinding
- Excessive yawning
- Pupil dilation
- Watery eyes
The head space of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.
- Emotion enhancement
- Thought acceleration
- Novelty enhancement
- Time distortion
- Increased music appreciation
- Analysis enhancement
- Personal bias suppression
- Conceptual thinking
- Memory suppression
- Immersion enhancement
- Thought loops
- Drifting (melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and extremely realistic in style but with a subtle digital/cartoonish form.
- After images
- Symmetrical texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel with slightly more mystical and shamanic undertones in comparison to other phenethylamines. At higher dosages, they are equally likely to result in states of Level 8A visual geometry or Level 8B. There seems to be a visual geometry that is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity and equal in proportion to the accompanying cognitive and physical effects.
2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - This effect is very consistent in dark environments at appropriately high dosages. They can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- Third Confirmed 2C-T-7 Death by Erowid Apr 10, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death3.shtml
- A Reported 2C-T-7 Death by Erowid July 2003 | https://www.erowid.org/chemicals/2ct7/2ct7_death1.shtml
- Second Reported 2C-T-7 Death by Erowid Apr 2, 2001 | https://www.erowid.org/chemicals/2ct7/2ct7_death2.shtml
- Zimmerman, M.M., “The identification of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7).” Microgram, Vol. XXXIV, No. 7, July 2001, pp. 169-173.
- https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
- https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
- Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats | http://link.springer.com/article/10.1007/s00213-005-0009-4
- Wagmann, Lea; Brandt, Simon D.; Stratford, Alexander; Maurer, Hans H.; Meyer, Markus R. (2019). "Interactions of phenethylamine-derived psychoactive substances of the 2C-series with human monoamine oxidases". Drug Testing and Analysis. 11 (2): 318–324. :10.1002/dta.2494. 1942-7603.
- Curtis, B., Kemp, P., Harty, L., Choi, C., & Christensen, D. (2003). Postmortem identification and quantitation of 2, 5-dimethoxy-4-n-propylthiophenethylamine using GC-MSD and GC-NPD. Journal of analytical toxicology, 27(7), 493-498.
- 2C-T-7 Overdoses & Delirium | https://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml#overdose
- Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
- Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
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- "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
- Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
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- 1717 CheMall OR006813
- AKos AKOS015897279
- Amadis Chemical A814871
- American Custom Chemicals Corp CHM0008076
- Apexmol AM20080771
- Ark Pharm, Inc. AK400823
- Atomole Scientific AT-4033
- Aurora Fine Chemicals K18.728.317
- ChEMBL CHEMBL126432
- ChemIDplus 207740269
- Chemspace CSC000018474
- Debyesci DB-032697
- DrugBank DB01458
- eMolecules 977274
- Erowid 2C-T-7
- FDA UNII - NLM TJG366J9BA
- FDA UNII - NLM UNII: TJG366J9BA
- iChemical EBD12831
- Jalor-Chem I09-0527
- LeadScope LS-191093
- Mcule MCULE-3386545182
- PubMed 15029891
- PubMed 15983786
- PubMed 16325192
- PubMed 17614010
- Sayibo Inc W47339
- Sinova SL-00748
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- Wikidata Q222010
- Wikipedia 2C-T-7
Information made possible with:
- PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
- Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
- PubChem National Center for Bio Informatics
- Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.
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