2C-T-2

2C-T-2

2C-T-2

Psychoactive Research chemicals are new synthetic substances that are structurally similar to the original drug, while being functional analogs. Research on the effects of, and treatment for, abuse of these drugs is limited due to the fact that they’re fairly new and have avoided mainstream notice. Research chemicals do not have a lot of human consumption data, and thus harm-reduction and special care should be taken if choosing to ingest them.

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Description

2C-T-2

Also known as:

  • 2,5-Dimethoxy-4-(ethylthio) phenethylamine
  • 2,5-Dimethoxy-4-(ethylthio)phenethylamine
  • 2,5-Dimethoxy-4-Ethylthiophenethylamine
  • 2-[4-(Ethylsulfanyl)-2,5-dimethoxyphenyl]ethanamin[German][ACD/IUPAC Name]
  • 2-[4-(Ethylsulfanyl)-2,5-dimethoxyphenyl]ethanamine[ACD/IUPAC Name]
  • 2-[4-(Éthylsulfanyl)-2,5-diméthoxyphényl]éthanamine[French][ACD/IUPAC Name]
  • 2-C-T-2
  • Benzeneethanamine, 4-(ethylthio)-2,5-dimethoxy-[ACD/Index Name]
  • 2-(4-(Ethylthio)-2,5-dimethoxyphenyl)ethanamine
  • 2-(4-ethylsulfanyl-2,5-dimethoxyphenyl)ethanamine
  • 2-(4-ethylsulfanyl-2,5-dimethoxy-phenyl)ethanamine
  • 2-(4-Ethylsulfanyl-2,5-dimethoxy-phenyl)-ethylamine
  • 2-(4-ethylthio-2,5-dimethoxyphenyl)ethylamine
  • 2,5-Dimethoxy-4-ethylthiophenethyl amine HCl
  • 2-[4-(Ethylthio)-2,5-dimethoxyphenyl]ethanamine
  • 2-[4-(ethylthio)-2,5-dimethoxy-phenyl]ethylamine
  • 2C-T-2
  • MFCD03840818[MDL number]
  • phenethylamine, 2,5-dimethoxy-4-ethylthio-

An unusual psychedelic with similar effects to 2C-B and a slightly longer duration, but maligned because of some deaths in the 2000s. Also similar to 2c-t-7, but with a shorter duration. Potentially unsafe with stimulants and empathogens.

Summary

It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule. 2C-T-2 was first synthesized and tested for activity in humans by Alexander Shulgin in 1981 and described in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself.

They are found within the first book of PiHKAL, and are as follows: mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7. Anecdotal reports generally characterize 2C-T-2 as a highly dose sensitive psychedelic known for its open headspace and unpredictable body load. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has a relatively short history of human usage.

Many reports also indicate that its physical effects may be too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions. It is highly advised to approach this hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.

History

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Following the initial positive results found by Shulgin’s research group, a more formal study was carried out by psychedelic psychotherapy pioneer Myron J. Stolaroff who was interested in evaluating the potential use of 2C-T-2 in psychotherapy. Based on the experiences of forty participants in the study who took 2C-T-2, Stolaroff compared the effects favorably to MDMA, describing it as more emotionally opening and permitting a wider exploration of feelings and thoughts.

Chemistry

2C-T-2

2C-T-2

2C-T-2 belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring.

2C-T-2 is also substituted at R4 with an ethyl thioether group. 2C-T-2 is a close structural analogue of 2C-T-7; the two differ by the length of the alkane chain in their thioether functional group.

Common Name2,5-Dimethoxy-4-Ethylthiophenethylamine
Systematic name2,5-Dimethoxy-4-Ethylthiophenethylamine
FormulaC_{12}H_{19}NO_{2}S
SMILESCCSc1cc(c(cc1OC)CCN)OC
Std. InChiInChI=1S/C12H19NO2S/c1-4-16-12-8-10(14-2)9(5-6-13)7-11(12)15-3/h7-8H,4-6,13H2,1-3H3
Std. InChiKeyHCWQGDLBIKOJPM-UHFFFAOYSA-N
Avg. Mass241.3498 Da
Molecular Weight241.3498
Monoisotopic Mass241.113647 Da
Nominal Mass241
ChemSpider ID16787961

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Dosing Guide

Oral
Threshold5mg
Light5-10mg
Common10-20mg
Strong20-25mg+

Duration

2C-T-2 Duration Data
Onset45-90 minutes
Duration5-8 hours
After-effects1-6 hours

Interactions and Synergies

There are no existing interaction or synergy data for this drug.

General Information

Experiences
Oral
Vaporization
Come up
Dosage
EffectsEuphoria, empathy, insight, brightened colour, Closed/Open eye visuals, enhanced tactile sensation, mental/physical stimulation, decreased appetite, pupil dilation, restlessness, change in perception, ego softening, sweating/chills, muscle tension, confusion, insomnia.
After Effects
AvoidMAOI's as the dangers with 2C-T-7 could also fall into this substance as well (Serotonin Syndrome)
Warning
Risks
Test Kits
Marguis Test Result
Tolerance
Detection
Half-life
Advice
Note
Note 2:
Note 3:

Effects

Pharmacological Effects

The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines. Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (4-MTA, and the 2,5-desmethoxy derivative of 2C-T-7) are known to act as selective monoamine oxidase A inhibitors. Furthermore, many compounds of the amphetamine-analogs of the 2C-T-x have been found to have highly selective MAO-A inhibition. Therefore, this substance may likewise have MAOI effects. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Physical Effects

Psychological Effects

The head space of 2C-T-2 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high doses.

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry that is present throughout this experience can be described as somewhat similar in appearance to that of ayahuasca, psilocin, and 4-AcO-DMT with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of LSD or 2C-E. 2C-T-2's geometry can be comprehensively described through its variations as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of DOC or 2C-P. Higher doses are more likely to result in states of level 8B visual geometry, but may also lead into level 8A visual geometry (as with 2C-T-7).

Hallucinatory states

At common to high doses, 2C-T-2 is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamines family. These effects include:

  • Transformations
  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as ayahuasca, 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-T-2 is very high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.

Auditory Effects

Sensory Effects

Transpersonal Effects

Legal Status

  • Australia: 2C-T-2 is illegal in Australia as of 2005.
  • Austria: 2C-T-2 is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich).
  • Belgium: 2C-T-2 was added to the list of illegal psychotropic substances on Nov 8, 2004.
  • Brazil: 2C-T-2 is illegal to possess, produce and sell as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-T-2 would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: As of October 2015, 2C-T-2 is a controlled substance in China.
  • Denmark: 2C-T-2 was added to category B of the controlled substances list on August 23, 2003.
  • European Union: The EU Council published an order on Dec 6, 2003, asking all member states to control 2C-I, 2C-T-2, 2C-T-7, and TMA-2.
  • Germany: 2C-T-2 is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of October 10, 1998. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Italy: 2C-T-2 was added to the "Tabella 1" in a Jan 11, 2005 Ministry of Health statement.
  • Japan: 2C-T-2 is controlled as a "Designated Substance" (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell.
  • Latvia: 2C-T-2 is a Schedule I controlled substance.
  • The Netherlands: 2C-T-2 was classified as an unregistered pharmaceutical as of April 12, 1999. Unlicensed manufacture, sale, import, trade and possession of this substance can be prosecuted.
  • Switzerland: 2C-T-2 is illegal to possess, produce and sell.
  • United Kingdom: 2C-T-2 is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: 2C-T-2 is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.

  • References

    1. Shulgin, Alexander. "Pharmacology Lab Notes #4". Lafayette, CA. (1981-1982). p474 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_pharmacology_notebook4_searchable.pdf
    2. Shulgin, A., & Shulgin, A. (1991). IsomerDesign: "PiHKAL" - #33 - 2C-I. Retrieved Jan 22, 2018.
    3. Shulgin, A., & Shulgin, A. (1991). Erowid Online Books: "PIHKAL" - The Chemical Story. Retrieved April 14, 2017.
    4. Stolaroff, MJ; Wells, C. Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Jahrbuch für Ethnomedizin und Bewußtseinsforschung (Yearbook of Ethnomedicine and the Study of Consciousness); Rätsch, C; Baker, J, Eds., 1993; Vol. 2, pp 99–117. (MAPS.org) | http://www.maps.org/images/pdf/1993_stolaroff_1.pdf
    5. http://isomerdesign.com/PiHKAL/read.php?id=40
    6. https://www.ncbi.nlm.nih.gov/pubmed/15801832
    7. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.689.281&rep=rep1&type=pdf
    8. http://www.sciencedirect.com/science/article/pii/S0006295206005971
    9. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
    10. http://portal.anvisa.gov.br/documents/10181/3115436/(1)RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
    11. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
    12. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
    13. https://www.riigiteataja.ee/aktilisa/1090/2201/1004/109022011004Lisa1.pdf
    14. "Zwölfte Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    15. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    16. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    17. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
    18. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
    19. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made

    Sources

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks for ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.