Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

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2C-E Also known as:

  • 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Éthyl-2,5-diméthoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 2,5-dimethoxy-4-ethyl-phenethylamine
  • 2,5-Dimethoxy-4-ethylphenethylamine
  • Benzeneethanamine, 4-ethyl-2,5-dimethoxy-[ACD/Index Name]
  • I190284UXX
  • 2-(4-Ethyl-2,5-dimethoxy-phenyl)-ethylamine
  • CHEMBL124063
  • phenethylamine, 2,5-dimethoxy-4-ethyl-
  • UNII:I190284UXX

An intense psychedelic drug with very strong visuals, sometimes criticised for its relatively uncomfortable body load. Otherwise, effects are comparable to other 2c-x drugs.


It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood. 2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").

It began to appear in drug seizures around 2004. While primarily distributed online as a research chemical, it is also sometimes distributed on the street as ‘mescaline’ or ‘synthetic mescaline’. Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria.

User reports characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic that is capable of producing strong visual distortions along with a significant “body load”, which includes nausea and bodily discomfort. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens.

It is highly advised to use harm reduction practices if using this substance.


2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.




2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring.

2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Common Name2C-E
Systematic name2C-E
Std. InChiInChI=1S/C12H19NO2/c1-4-9-7-12(15-3)10(5-6-13)8-11(9)14-2/h7-8H,4-6,13H2,1-3H3
Avg. Mass209.2848 Da
Molecular Weight209.2848
Monoisotopic Mass209.141586 Da
Nominal Mass209
ChemSpider ID21106222

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Dose Chart


Duration Chart

2C-E Duration Data
Onset20-90 minutes
Duration6-14 hours
After-effects2-6 hours



  1. Mescaline
  2. DOx
  3. NBOMes
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  8. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  9. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

Auditory Effects

Psychological Effects

The head space of 2C-E is described by many as one which is both insightful and relatively unaltered in its thought processes even at moderate to high dosages. Some users suggest that 2C-E may be even more clearheaded than 2C-B or 2C-C especially at higher dosages.

Pharmacological Effects

2C-E’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of ongoing scientific investigation.

Physical Effects

  • Stimulation - 2C-E is usually considered to be very energetic and stimulating in a fashion that is comparable to that of MDMA, although it is 'encouraged' instead of 'forced'.
  • Spontaneous bodily sensations - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over the surface of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in intermittent waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
    • Physical euphoria - Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
  • Tactile enhancement
  • Bodily control enhancement
  • Temperature regulation suppression
  • Muscle contractions
  • Increased heart rate
  • Increased blood pressure
  • Increased perspiration
  • Nausea - Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the user has vomited or gradually fades by itself as the peak sets in.
  • Dehydration
  • Frequent urination
  • Pupil dilation
  • Teeth grinding - This component can be considered to be less intense when compared with that of entactogenic stimulants like MDMA.
  • Seizure - This is a rarely observed effect but is believed to be a risk in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states. However, many reports indicate that this substance is relatively reliable at inducing synaesthetic states in those who are predisposed to them.

Subjective Effects

Disclaimer: The effects listed below are cited from the Subjective Effect Index (SEI), which relies on assorted anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death.

Visual Effects




The visual geometry that is produced by this substance can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 8B visual geometry over Level 8A.

Hallucinatory states

2C-E produces a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This particularly holds true in comparison to other substances within the family of psychedelic phenethylamines. These effects include:

Legal Status

  • Austria: 2C-E is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-E would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: As of October 2015 2C-E is a controlled substance in China.
  • Denmark: 2C-E is a Schedule I drug.
  • Finland: The possession, production and sale is illegal.
  • Germany: 2C-E is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Israel: Possession, production and sale is illegal.
  • Latvia: 2C-E is a Schedule I controlled substance.
  • New Zealand: 2C-E is a Class C drug.
  • Sweden: 2C-E is a Schedule I drug.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: 2C-E is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: 2C-E is a Schedule I drug.
  • Sources


    2. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 ( |
    3. Shulgin, A., & Shulgin, A. (1991). Read #24 2C-E | PiHKAL  · info. Retrieved Jan 22, 2018.
    4. "2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 ( |
    5. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 ( |
    7. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    9. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |
    10. China Food and Drug Administration. (2017, April 10). 关于印发《非药用类麻醉药品和精神药品列管办法. Retrieved from
    11. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    12. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    13. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    14. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) |
    16. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from

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    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
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