Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is a commonly used substance with well known effects, but that does not guarantee the substance will be safe. The safety profile has been established based on usage data commonly reported by others.

Disclaimer: Psychedelic drugs offer some of the most powerful and intense psychological experiences. Additionally these substances are illegal in many places. We understand that even though these substances are illegal, their use occurs frequently. We do not condone breaking of the law. By providing accurate information about these substances, we encourage the user to make responsible decisions and practice harm reduction.

Read the full disclaimer here.

Description

2C-E Also known as:

  • 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(4-Ethyl-2,5-dimethoxyphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(4-Éthyl-2,5-diméthoxyphényl)éthanamine[French][ACD/IUPAC Name]
  • 2,5-dimethoxy-4-ethyl-phenethylamine
  • 2,5-Dimethoxy-4-ethylphenethylamine
  • Benzeneethanamine, 4-ethyl-2,5-dimethoxy-[ACD/Index Name]
  • I190284UXX
  • 2-(4-Ethyl-2,5-dimethoxy-phenyl)-ethylamine
  • 2,5-DIMETHOXY-4-ETHYL PHENETHYLAMINE
  • CHEMBL124063
  • http://en.atomaxchem.com/71539-34-9.html
  • phenethylamine, 2,5-dimethoxy-4-ethyl-
  • UNII:I190284UXX

An intense psychedelic drug with very strong visuals, sometimes criticised for its relatively uncomfortable body load. Otherwise, effects are comparable to other 2c-x drugs.

Summary

It is a member of the 2C-x family of psychedelic phenethylamines, which are closely related to the classical psychedelic mescaline. Like other psychedelics, it is thought to produce its effects by binding to serotonin receptors in the brain, although the precise mechanism is poorly understood. 2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").

It began to appear in drug seizures around 2004. While primarily distributed online as a research chemical, it is also sometimes distributed on the street as ‘mescaline’ or ‘synthetic mescaline’. Subjective effects include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria.

User reports characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic that is capable of producing strong visual distortions along with a significant “body load”, which includes nausea and bodily discomfort. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-E, and it has a limited history of human use. Many reports indicate that the safe use of this substance may be overly difficult for those who are not already experienced with hallucinogens.

It is highly advised to use harm reduction practices if using this substance.

History

2C-E was first synthesized and tested for human activity by Alexander Shulgin in 1977, who documented his findings in the 1991 book PiHKAL ("Phenethylamines I Have Known and Loved"). It is a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine-derived compounds, all of which except mescaline he developed and synthesized himself. They are found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.

Chemistry

2C-E contains methoxy functional groups CH3O- attached to carbons R2 and R5 and an ethyl chain bound to carbon R4 of the phenyl ring.

2C-E belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Common Name2C-E
Systematic name2C-E
FormulaC_{12}H_{19}NO_{2}
SMILESCCc1cc(c(cc1OC)CCN)OC
Std. InChiInChI=1S/C12H19NO2/c1-4-9-7-12(15-3)10(5-6-13)8-11(9)14-2/h7-8H,4-6,13H2,1-3H3
Std. InChiKeyVDRGNAMREYBIHA-UHFFFAOYSA-N
Avg. Mass209.2848 Da
Molecular Weight209.2848
Monoisotopic Mass209.141586 Da
Nominal Mass209
ChemSpider ID21106222

Become an Exclusive Member For Free

Become a member now, sign up, and get free updates, news articles, and the latest happenings in the Psychedelic World.

Dose Chart

Oral
Light5-10mg
Common10-15mg
Strong15-30mg
Heavy25-40mg
Insufflated
Light1-3mg
Common3-7mg
Strong6-10mg
Heavy10mg+

Duration Chart

2C-E Duration Data
Onset20-90 minutes
Duration6-14 hours
After-effects2-6 hours

Interactions

Caution

  1. Mescaline
  2. DOx
  3. NBOMes
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  8. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  9. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably

Dangerous

  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.

Low Synergy

  1. Alcohol
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
  5. MXE
  6. DXM
  7. PCP
  8. N2O
  9. MDMA

Legal Status

  • Austria: 2C-E is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-E would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: As of October 2015 2C-E is a controlled substance in China.
  • Denmark: 2C-E is a Schedule I drug.
  • Finland: The possession, production and sale is illegal.
  • Germany: 2C-E is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Israel: Possession, production and sale is illegal.
  • Latvia: 2C-E is a Schedule I controlled substance.
  • New Zealand: 2C-E is a Class C drug.
  • Sweden: 2C-E is a Schedule I drug.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: 2C-E is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: 2C-E is a Schedule I drug.

    • Sources

    References

    1. https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms
    2. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
    3. Shulgin, A., & Shulgin, A. (1991). Read #24 2C-E | PiHKAL  · info. Retrieved Jan 22, 2018.
    4. "2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf
    5. Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf
    6. http://isomerdesign.com/PiHKAL/read.php?id=24
    7. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    8. http://portal.anvisa.gov.br/documents/10181/3115436/(1)RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
    9. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
    10. China Food and Drug Administration. (2017, April 10). 关于印发《非药用类麻醉药品和精神药品列管办法. Retrieved from http://www.buzzle.com
    11. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    12. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    13. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    14. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
    15. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
    16. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/1977/1243/made
    17. http://www.justice.gov/ola/views-letters/112/093011-ltr-re-hr1254-synthetic-drug-control-act-2011.pdf

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

    Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

    Data is constantly updated so please check back later to see if there is any more available information on this substance.