Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

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2C-D Also known as:

  • 2-(2,5-Dimethoxy-4-methylphenyl)ethanamin[German][ACD/IUPAC Name]
  • 2-(2,5-Dimethoxy-4-methylphenyl)ethanamine[ACD/IUPAC Name]
  • 2-(2,5-Diméthoxy-4-méthylphényl)éthanamine[French][ACD/IUPAC Name]
  • 2,5-dimethoxy-4-methyl-phenethylamine
  • 2,5-Dimethoxy-4-Methylphenethylamine
  • 2,5-dimethoxy-4-methyl-β-phenethylamine
  • Benzeneethanamine, 2,5-dimethoxy-4-methyl-[ACD/Index Name]
  • 2-(2,5-dimethoxy-4-methyl-phenyl)ethanamine
  • 2-(2,5-dimethoxy-4-methyl-phenyl)ethylamine
  • 2-(2,5-Dimethoxy-4-methyl-phenyl)-ethylamine
  • 2,5-Dimethoxy-4-methylbenzeneethanamine
  • 2,5-Dimethoxy-4-methylphenethylamine Hydrochloride
  • 2,5-Dimethoxy-4-methylphenylethylamine
  • 2C-D
  • 4-Methyl-2,5-di-meo-pea
  • 4-Methyl-2,5-Dimethoxyphenethylamine
  • CHEMBL124049
  • phenethylamine, 2,5-dimethoxy-4-methyl-

A fairly generic psychedelic famed for being usable as “psychedelic tofu”. Little character of its own but pleasant in combinations.


Its sensory and cognitive effects profile has been described as being the most similar to that of mescaline among members of the 2C-x family, albeit with a significantly shorter duration. The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences. Initial trials by Alexander Shulgin at sub-threshold doses in humans were carried out in 1964.

Many anecdotal reports suggest that it is calmer, easier to handle and more comfortable on the body than other closely related psychedelic phenethylamines. While not especially visual or physically euphoric at common doses, it is reported to be very lucid, analytical and unimpaired in its headspace - a quality it retains even as the dose is increased. Lower doses of 2C-D (generally 10 mg or less) have been explored for its use as a potential nootropic, albeit with mixed results.

Today, 2C-D is used both recreationally and as an entheogen. It is rarely sold on the streets and almost exclusively distributed as a gray area research chemical by online vendors.


Further investigations at higher doses were carried out by Shulgin and his fellow researchers between 1974 and 1978. The name '2C-D' derives from the chemical's structure - it is the 2-Carbon analogue of DOM. Shulgin notably referred to 2C-D as a “pharmacological tofu,” meaning it can extend or potentiate the effect of other substances without overly coloring the experience, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with. While some use this as evidence that 2C-D is relatively uninteresting as a psychedelic on its own, others strongly disagree with this assessment and hold that 2C-D is an unusually versatile and fully-fledged psychedelic in its own right. Despite showing promise as a very functional psychostimulant with successful studies investigating the use in psychotherapy in Germany, 2C-D has not found widespread use.

This has been argued to be due to the previously limited diversity of substances on the market - a consumer dynamic which has changed significantly with the advent of the internet - allowing a broader freedom of choice for explorers of psychedelic phenethylamines. Of these, it tends to be substantially harder to find and notably more expensive by weight.


2C-D contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a methyl group attached to carbon R4 of the phenyl ring. 2C-D belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.

Common Name2,5-Dimethoxy-4-Methylphenethylamine
Systematic name2,5-Dimethoxy-4-Methylphenethylamine
Std. InChiInChI=1S/C11H17NO2/c1-8-6-11(14-3)9(4-5-12)7-10(8)13-2/h6-7H,4-5,12H2,1-3H3
Avg. Mass195.2582 Da
Molecular Weight195.2582
Monoisotopic Mass195.125931 Da
Nominal Mass195
ChemSpider ID119559

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Dose Chart


Duration Chart

2C-D Duration Data
Onset15-45 minutes
Duration3-5 hours
After-effects1-8 hours



  1. Mescaline
  2. DOx
  3. NBOMes
  4. 2C-T-x
  5. 5-MeO-xxT
    • The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  6. Cannabis
    • Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
  7. Amphetamines
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  8. Cocaine
    • The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  9. MAOIs
    • MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably


  1. Tramadol
    • Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.

Low Synergy

  1. Alcohol
  2. GHB/GBL
  3. Benzodiazepines
  4. SSRIs

No Synergy

  1. Caffeine
    • High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
  2. Opioids

High Synergy

  1. Mushrooms
  2. LSD
  3. DMT
  4. Ketamine
  5. MXE
  6. DXM
  7. PCP
  8. N2O
  9. MDMA

Legal Status

  • Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.
  • Austria: 2C-D is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
  • Brazil: Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.
  • Canada: 2C-D would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.
  • China: 2C-D is a controlled substance in China as of October 2015.
  • Denmark: 2C-D is added to the list of Schedule B controlled substances.
  • Germany: 2C-D is controlled under Anlage I BtMG (Narcotics Act, Schedule I) as of December 13, 2014. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
  • Japan: 2C-D is controlled by the Pharmaceutical Affairs Law in Japan, making it illegal to possess or sell.
  • Latvia: 2C-D is a Schedule I controlled substance.
  • Sweden: 2C-D is classified as a health hazard as of March 1, 2005, in the regulation SFS 2005:26, making it illegal to sell or possess.
  • Switzerland: Possession, production and sale is illegal.
  • United Kingdom: 2C-D is a Class A drug in the United Kingdom as a result of the phenethylamine catch-all clause.
  • United States: 2C-D is listed in Schedule I of section 202(c) of the Controlled Substances Act in the United States. This was signed into law as of July 2012 under the Food and Drug Administration Safety and Innovation Act.
  • Sources


    1. Amphetamine analogs. II. Methylated phenethylamines ( / NCBI) |
    2. Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p94, p175 ( |
    3. Lemaire, D. (1990). Erowid 2C-D Vault: Smart Pills, by Hosten & Lazar. Retrieved from
    4. Amphetamine analogs. II. Methylated phenethylamines ( / NCBI) |
    5. Shulgin, Alexander. "Pharmacology Lab Notes #1". Lafayette, CA. (1960-1976). p94, p175 ( |
    6. Zuba, D., & Sekula, K. (2013). Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Testing and Analysis, 5(8), 634–645.
    7. King, L. A. (2014). New phenethylamines in Europe. Drug Testing and Analysis, 6(7–8), 808–818.
    8. Schneider, U. (2004). Aspekte des Psychischen: Festschrift anlässlich des 60. Geburtstags von Hinderk M. Emrich. Würzbug, Germany: Königshausen & Neumann. No complete fulltext was available at the time of writing, please refer to the Google Scholar document:
    9. Martin, J. (2014). Drugs on the Dark Net. London: Palgrave Macmillan UK.
    10. Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. :10.1007/BF03161089.  1556-9039.
    11. New Psychoactive Substances (National Drug and Alcohol Research Centre 2014) | Psychoactive Substances.pdf
    13. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |
    14. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
    15. Bekendtgørelse om euforiserende stoffer |
    16. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (PDF) (in German). Bundesanzeiger Verlag. Retrieved December 10, 2019.
    17. "Anlage I BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    18. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 10, 2019.
    19. Analytical Data of Designated Substances (Shitei-Yakubutsu) Controlled by the Pharmaceutical AŠairs Law in Japan, Part I: GC-MS and LC-MS |
    20. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) |
    21. Svensk författningssamling |
    23. United Kingdom. (1977). Misuse of Drugs Act 1971 (S.I. 1977/1243). London: The Stationery Office Limited. Retrieved July 5, 2017, from
    24. S. 3187: Food and Drug Administration Safety and Innovation Act, Subtitle D-Synthetic Drugs |

    Information made possible with:

    1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
    2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
    3. PubChem National Center for Bio Informatics
    4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
    5. Wikipedia

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