Psychedelic Research Chemicals or RC Chems are new synthetic substances which are structurally similar to the original drug, while being functional analogs. Data on their effects limited due as they’re fairly new and do not have a lot of human consumption history.

Psychedelics are substances (natural or laboratory made) which cause profound changes in a one’s perceptions of reality. While under the influence of hallucinogens, users might hallcuniate visually and auditorily.

This is an Experimental Substance with little data. This is most likely because the substance is is not very old. Information is limite and incomplete.

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Description

2-Me-DMT Also known as:

  • 1H-Indole-3-ethanamine, N,N,2-trimethyl-[ACD/Index Name]
  • 2,N,N-Trimethyltryptamine
  • N,N-Dimethyl-2-(2-methyl-1H-indol-3-yl)ethanamin[German][ACD/IUPAC Name]
  • N,N-Dimethyl-2-(2-methyl-1H-indol-3-yl)ethanamine[ACD/IUPAC Name]
  • N,N-Diméthyl-2-(2-méthyl-1H-indol-3-yl)éthanamine[French][ACD/IUPAC Name]
  • P15UO6J3FK
  • 2-Me-DMT
  • CHEMBL7580
  • UNII:P15UO6J3FK

Also known as 2,N,N-TMT, this drug was first synthesised by Alexander Shulgin. Described as a very mild psychedelic of similar subjective effects to other tryptamines. Reported as having an unusual and unpredictable dose curve, it is recommended to start low with this drug.

Chemistry

2-Me-DMT

2-Me-DMT

Common Name2,N,N-TMT
Systematic name2,N,N-TMT
FormulaC_{13}H_{18}N_{2}
SMILESCc1c(c2ccccc2[nH]1)CCN(C)C
Std. InChiInChI=1S/C13H18N2/c1-10-11(8-9-15(2)3)12-6-4-5-7-13(12)14-10/h4-7,14H,8-9H2,1-3H3
Std. InChiKeyNDGCOWDSLVNLGE-UHFFFAOYSA-N
Avg. Mass202.2954 Da
Molecular Weight202.2954
Monoisotopic Mass202.147003 Da
Nominal Mass202
ChemSpider ID9994827

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Dose Chart

Oral
Light30-50mg
Common50-75mg
Strong75-100mg

Duration Chart

Oral
Onset60-90 minutes
Duration3-8 hours
After-effects1-5 hours

Auditory Effects

Psychological Effects

Pharmacological Effects

Based on its structural similarity to LSD, 1P-LSD likely acts as a partial agonist at the 5-HT2A receptor. The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain. 1P-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, there is currently no data to support these claims. It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo. Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect. Prior to the publishing of the above-cited research, medicinal chemist and psychedelic researcher David E. Nichols reportedly commented on the potential 1P-LSD serotonin receptor binding dynamics in private correspondence:

Physical Effects

  • Stimulation - 1P-LSD is usually regarded as very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocybin which are generally sedating and relaxed.
  • Spontaneous bodily sensations - The "body high" of 1P-LSD can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It behaves as a euphoric, fast-moving, sharp and location-specific tingling sensation. For some, it is manifested spontaneously at different, unpredictable points throughout the trip, but for most, it maintains a steady presence that rises with the onset and hits its limit once the peak has been reached. At moderate to high doses of 1P-LSD, this sensation often approaches its highest level and can become so overwhelming that people may find themselves debilitated with pleasurable sensations.
    • Physical euphoria - It should be noted that this effect is not as reliably induceable as it is with substances like stimulants or entactogens, and can just as easily manifest as extreme physical discomfort without any apparent reason.
  • Tactile enhancement - Feelings of enhanced tactile sensations are consistently present at moderate levels throughout most 1P-LSD experiences. If level 8A geometry is reached, an intense sensation of suddenly becoming aware of and being able to feel every single nerve ending across a person's entire body all at once is consistently present.
  • Stamina enhancement - This is generally mild in comparison to the stamina enhancement produced by traditional stimulants.
  • Appetite suppression
  • Bodily control enhancement
  • Difficulty urinating
  • Excessive yawning - This effect is significantly less pronounced than it is with psilocybin and its related compounds, the four-position substituted tryptamines.
  • Nausea - Mild nausea is occasionally reported when consumed in moderate to high dosages and either passes instantly soon after the user has vomited or gradually fades by itself as the peak sets in.
  • Increased blood pressure
  • Increased heart rate
  • Increased perspiration
  • Muscle contractions
  • Muscle spasms
  • Pupil dilation
  • Increased salivation
  • Vasoconstriction - Vasoconstriction may lead to users feeling cold, especially in the extremities.
  • Seizure - The likelihood is largely extrapolated from the seizures that have been reported from the use of LSD. It is thought to mainly be a risk in those who are genetically predisposed to them, particularly while accompanied by physically taxing conditions such as states of dehydration, fatigue, undernourishment or overheating.

Sensory Effects

  • Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.

Subjective Effects

Anecdotal reports from many users suggest that the subjective effects of 1P-LSD are so similar to that of LSD so as to be virtually indistinguishable from one another. In comparison to other psychedelics such as psilocybin, LSA and ayahuasca, 1P-LSD is significantly more stimulating and fast-paced regarding the specific style of its physical and cognitive effects.

Visual Effects

Enhancements

Distortions

Geometry

The visual geometry of 1P-LSD can be described as more similar in appearance to that of 2C-B or 2C-I than psilocin, LSA or DMT. It can be comprehensively described through its variations as primarily intricate in complexity, algorithmic in form, unstructured in organization, brightly lit, colourful in scheme, synthetic in feel, multicoloured in scheme, flat in shading, sharp in edges, large in size, fast in speed, smooth in motion, angular in its corners, non-immersive in-depth and consistent in intensity.

In the case of higher-level geometry, this substance is level 8A dominant but is also capable of inducing 8B Geometry under the right circumstances.

Hallucinatory states

1P-LSD is capable of producing a full range of hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics, specifically tryptamines like DMT or psilocybin mushrooms. These effects include:

Sources

Information made possible with:

  1. PsychonautWiki is a community-driven online encyclopedia that aims to document the field of psychonautics in a comprehensive, scientifically-grounded manner.
  2. Erowid is a non-profit educational & harm-reduction resource with 60 thousand pages of online information about psychoactive drugs
  3. PubChem National Center for Bio Informatics
  4. Chemspider is a free chemical structure database providing fast access to over 34 million structures, properties and associated information.
  5. Wikipedia

Additional APIs were used to construct this information. Thanks to ChemSpider, NCBI, PubChem etc.

Data is constantly updated so please check back later to see if there is any more available information on this substance.