Description

LSA Also known as:

• Ergine[Wiki]

• (+)-lysergamide

• (8β)-6-Methyl-9,10-didehydroergolin-8-carboxamid[German][ACD/IUPAC Name]

• (8β)-6-Methyl-9,10-didehydroergoline-8-carboxamide[ACD/IUPAC Name]

• (8β)-6-Méthyl-9,10-didéhydroergoline-8-carboxamide[French][ACD/IUPAC Name]

• 207-524-0[EINECS]

• 478-94-4[RN]

• 9,10-Didehydro-6-methylergoline-8b-carboxamide

• 9,10-Didehydro-6-methyl-ergoline-8-β-carboxamide

• Ergoline-8-carboxamide, 9,10-didehydro-6-methyl-, (8β)-

• Ergoline-8-carboxamide, 9,10-didehydro-6-methyl-, (8β)-[ACD/Index Name]

• Ergoline-8-β-carboxamide, 9,10-didehydro-6-methyl-

• lysergamide[Wiki]

• lysergic acid amide

• (6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

• (8R)-9,10-didehydro-6-methylergoline-8-carboxamide

• 9,10-didehydro-6-methylergoline-8β-carboxamide

• 9,10-DIDEHYDRO-6-METHYLERGOLINE-8-β-CARBOXAMIDE

• 90708[Beilstein]

• PDSP2_001113

A chemical found in Morning Glory and Hawaiian Baby Woodrose seeds, which are often legally available. Has mental effects similar to LSD, although with almost no visual effects. It is famous for being very nauseating, and for causing excessive time dilation at higher doses.

Summary

LSA is an ergot alkaloid and the main psychoactive constituent of morning glory seeds. LSA is chemically related to LSD and is said to produce similar effects, although the extent to which it does is unclear. LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.

In 1947, it was synthesized and tested for human activity by Albert Hofmann. The intramuscular administration of a 500 microgram dose produced a “tired, dreamy state with an inability to maintain clear thoughts. " In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as “mescaline”.

Today, LSA is typically consumed via morning glory and Hawaiian baby woodrose seeds. User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like LSD, psilocybin mushrooms, or mescaline.

LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious nausea and bodily discomfort (“body load”) when taking LSA-containing seeds. Like other psychedelics, LSA is not considered to be addictive.

However, adverse reactions such as severe anxiety, paranoia, and psychosis are always possible, particularly among those who are predisposed to psychiatric disorders. It is therefore highly advised to use harm reduction practices if using this substance.

Chemistry

The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN.

The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid).

At carbon 8 of the quinoline, an acetamide group is bound.

LSA is additionally substituted at carbon 6 with a methyl group. LSA is a chiral compound with two stereocenters at R5 and R8.

LSA, also called (+)-D-LSA, has an absolute configuration of (5R, 8R).

The three other stereoisomers of LSA do not have psychoactive properties.

LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group.

It can be used as a precursor to LSD.

Dose Chart

Duration Chart

Legal Status

Sources